c-Kit-IN-1_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.131055
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.124783
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.118381
MYO5B myosin VB 0.0963708
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.087173
NDRG1 N-myc downstream regulated 1 0.0846691
GPHN gephyrin 0.0830225
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0740626
HSPA8 heat shock 70kDa protein 8 0.0726135
COG5 component of oligomeric golgi complex 5 0.066394
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0662268
NBAS neuroblastoma amplified sequence 0.0657729
UPP1 uridine phosphorylase 1 0.0630765
GOLGA4 golgin A4 0.0610262
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0595921
CREB5 cAMP responsive element binding protein 5 0.0595452
RAB10 RAB10, member RAS oncogene family 0.0575909
SMYD3 SET and MYND domain containing 3 0.0573888
MARK3 MAP/microtubule affinity-regulating kinase 3 0.056806
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0559464
KMT2C lysine (K)-specific methyltransferase 2C 0.053639
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0531377
CCSER1 coiled-coil serine-rich protein 1 0.0529456
MACF1 microtubule-actin crosslinking factor 1 0.0529284
GSK3B glycogen synthase kinase 3 beta 0.0516329
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0503262
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0501769
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0500635
NUP58 nucleoporin 58 0.0490582
SEPTIN9 septin 9 0.0467256
SPAG9 sperm associated antigen 9 0.0450034
TFRC transferrin receptor 0.0446226
GARS1 glycyl-tRNA synthetase 1 0.0443863
HOOK2 hook microtubule-tethering protein 2 0.0434294
ZFAND3 zinc finger, AN1-type domain 3 0.042402
MYH9 myosin, heavy chain 9, non-muscle 0.0418163
ANK2 ankyrin 2, neuronal 0.0412479
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0410999
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0404244
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0400736
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0399802
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0399107
NAMPT nicotinamide phosphoribosyltransferase 0.0394797
SND1 staphylococcal nuclease and tudor domain containing 1 0.039236
ARFGEF3 ARFGEF family member 3 0.0392323
RCOR1 REST corepressor 1 0.0391699
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0388135
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0385793
MAP4 microtubule-associated protein 4 0.0384226
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0383656
AHNAK AHNAK nucleoprotein 0.0382888
TRIO trio Rho guanine nucleotide exchange factor 0.0380473
ESYT2 extended synaptotagmin-like protein 2 0.0374847
TRAF3 TNF receptor-associated factor 3 0.0374138
ANKRD11 ankyrin repeat domain 11 0.0373621
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0373307
GMDS GDP-mannose 4,6-dehydratase 0.0372649
FMNL2 formin-like 2 0.0371356
CALU calumenin 0.0370747
HOMER1 homer scaffolding protein 1 0.0363435
PLAUR plasminogen activator, urokinase receptor 0.0359552
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0357357
GPATCH2L G patch domain containing 2-like 0.0356962
USP9X ubiquitin specific peptidase 9, X-linked 0.0349687
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0348849
BIRC3 baculoviral IAP repeat containing 3 0.0334355
PCDHB16 protocadherin beta 16 0.0332693
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0332529
NGLY1 N-glycanase 1 0.0327326
ABTB3 ankyrin repeat and BTB domain containing 3 0.0326125
CDK13 cyclin-dependent kinase 13 0.0319183
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0317592
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0315316
C3ORF52 chromosome 3 open reading frame 52 0.0314401
SRRM2 serine/arginine repetitive matrix 2 0.0309862
USP34 ubiquitin specific peptidase 34 0.0309482
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0306802
CCNY cyclin Y 0.0306564
LAMB3 laminin, beta 3 0.0306055
PRELID2 PRELI domain containing 2 0.0296998
RNF216 ring finger protein 216 0.0295466
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0294553
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0293351
SEC24D SEC24 family member D 0.0292512
PTPRG protein tyrosine phosphatase, receptor type, G 0.0291483
SNX9 sorting nexin 9 0.0291178
KLF5 Kruppel-like factor 5 (intestinal) 0.0287923
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0287804
TTC3 tetratricopeptide repeat domain 3 0.0284241
PFKP phosphofructokinase, platelet 0.0282913
EEF2 eukaryotic translation elongation factor 2 0.0281023
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.028069
RREB1 ras responsive element binding protein 1 0.0278123
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0277462
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0276376
MAP2K1 mitogen-activated protein kinase kinase 1 0.0275762
ANKRD10 ankyrin repeat domain 10 0.0271599
SCFD1 sec1 family domain containing 1 0.0270802
CAMKMT calmodulin-lysine N-methyltransferase 0.0266877
SVIL supervillin 0.026668

decreased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) -0.197945
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.196179
PTMA prothymosin, alpha -0.186308
LMO7 LIM domain 7 -0.121941
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114473
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.105245
RPS6 ribosomal protein S6 -0.104925
TMSB10 thymosin beta 10 -0.0792178
OXR1 oxidation resistance 1 -0.067719
RPS8 ribosomal protein S8 -0.0564819
EZR ezrin -0.0556734
TPT1 tumor protein, translationally-controlled 1 -0.0541236
RAD51B RAD51 paralog B -0.0538559
RPL35A ribosomal protein L35a -0.0503374
RPS3 ribosomal protein S3 -0.0490144
HDAC2 histone deacetylase 2 -0.0484006
EGFR epidermal growth factor receptor -0.0466399
RPS19 ribosomal protein S19 -0.0439715
RPS29 ribosomal protein S29 -0.0436317
ACTG1 actin gamma 1 -0.0413967
PDE4B phosphodiesterase 4B, cAMP-specific -0.0413551
RPLP1 ribosomal protein, large, P1 -0.0411559
RPLP2 ribosomal protein, large, P2 -0.0394433
RPL12 ribosomal protein L12 -0.0391471
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.037892
RPL19 ribosomal protein L19 -0.037597
RPS13 ribosomal protein S13 -0.0373006
NEK7 NIMA-related kinase 7 -0.0361227
RUNX2 runt-related transcription factor 2 -0.0357863
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0347242
PERP PERP, TP53 apoptosis effector -0.0347239
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0346974
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0341078
RPL8 ribosomal protein L8 -0.0336307
EIF1 eukaryotic translation initiation factor 1 -0.0332538
RPL31 ribosomal protein L31 -0.033177
LOC102724023 ES1 protein homolog, mitochondrial -0.0330433
RPL34 ribosomal protein L34 -0.0329064
MT2A metallothionein 2A -0.0319693
RPLP0 ribosomal protein, large, P0 -0.0305495
RPS24 ribosomal protein S24 -0.0300135
RPL26 ribosomal protein L26 -0.0297739
RPS17 ribosomal protein S17 -0.0297326
RPL23 ribosomal protein L23 -0.0295453
RPL11 ribosomal protein L11 -0.0294874
RPS25 ribosomal protein S25 -0.0294694
RPS14 ribosomal protein S14 -0.0291966
RPL9 ribosomal protein L9 -0.0291459
RPL36 ribosomal protein L36 -0.0290052
CD9 CD9 molecule -0.0289849
FTL ferritin, light polypeptide -0.0288367
BAMBI BMP and activin membrane-bound inhibitor -0.0288194
RACK1 receptor for activated C kinase 1 -0.0284188
RPL5 ribosomal protein L5 -0.0283067
RPS27A ribosomal protein S27a -0.0276373
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0275527
RPS23 ribosomal protein S23 -0.0270916
TXNIP thioredoxin interacting protein -0.0267937
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0265856
RPS15 ribosomal protein S15 -0.0263111
CENPF centromere protein F, 350/400kDa -0.0262041
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0261257
RPL13A ribosomal protein L13a -0.025406
AKAP12 A kinase (PRKA) anchor protein 12 -0.0248389
ANXA1 annexin A1 -0.024396
RPS12 ribosomal protein S12 -0.0242795
S100A10 S100 calcium binding protein A10 -0.0242041
HLA-B major histocompatibility complex, class I, B -0.0240597
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0238986
KLK10 kallikrein-related peptidase 10 -0.0237124
HILPDA hypoxia inducible lipid droplet-associated -0.0235439
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0234136
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0230462
RPS5 ribosomal protein S5 -0.0228601
RPS21 ribosomal protein S21 -0.0226514
BCL2L1 BCL2-like 1 -0.0225672
FTH1 ferritin, heavy polypeptide 1 -0.0225622
S100A6 S100 calcium binding protein A6 -0.0223845
AKAP9 A kinase (PRKA) anchor protein 9 -0.0219634
ARHGAP42 Rho GTPase activating protein 42 -0.0215923
RPS16 ribosomal protein S16 -0.0215266
AREG amphiregulin -0.0215236
BMP4 bone morphogenetic protein 4 -0.0215034
RPS10 ribosomal protein S10 -0.0212718
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0212022
NCEH1 neutral cholesterol ester hydrolase 1 -0.0210451
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0210089
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0206281
KLF3 Kruppel-like factor 3 (basic) -0.0206065
GDF15 growth differentiation factor 15 -0.0204895
EMP1 epithelial membrane protein 1 -0.0202673
DEK DEK proto-oncogene -0.0202481
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0200778
PHIP pleckstrin homology domain interacting protein -0.0200153
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0199567
RPL28 ribosomal protein L28 -0.019845
RB1CC1 RB1-inducible coiled-coil 1 -0.019785
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0197689
CPOX coproporphyrinogen oxidase -0.0196344
MAML3 mastermind-like 3 (Drosophila) -0.0192679