c-Kit-IN-1_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.136559
NAV2 neuron navigator 2 0.100732
CDH13 cadherin 13 0.0872956
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0861021
ASPH aspartate beta-hydroxylase 0.0775762
HSPA8 heat shock 70kDa protein 8 0.0707775
TRIO trio Rho guanine nucleotide exchange factor 0.0649058
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0567247
WWOX WW domain containing oxidoreductase 0.0565077
LDHA lactate dehydrogenase A 0.0563697
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0563383
GMDS GDP-mannose 4,6-dehydratase 0.0551018
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0526735
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0515118
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0509214
BACE2 beta-site APP-cleaving enzyme 2 0.0502972
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0497934
RBM26 RNA binding motif protein 26 0.0485551
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0476307
CMIP c-Maf inducing protein 0.0472897
SFPQ splicing factor proline/glutamine-rich 0.0463324
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0461481
SYT1 synaptotagmin I 0.0453304
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0447724
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0446604
FRMD5 FERM domain containing 5 0.0443595
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0440766
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0439407
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0436261
IPO7 importin 7 0.0434758
MYH9 myosin, heavy chain 9, non-muscle 0.0420316
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0410405
WDR43 WD repeat domain 43 0.0405312
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0402839
ZFAND3 zinc finger, AN1-type domain 3 0.0399403
ETNK1 ethanolamine kinase 1 0.0398996
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0395161
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0390548
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0384445
FMNL2 formin-like 2 0.0377674
ANO6 anoctamin 6 0.0376988
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0364323
GPHN gephyrin 0.0362708
PGK1 phosphoglycerate kinase 1 0.036194
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0359373
OSBPL3 oxysterol binding protein-like 3 0.0355942
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.035466
NHSL1 NHS-like 1 0.0352336
TFRC transferrin receptor 0.0348141
GRB10 growth factor receptor-bound protein 10 0.0346952
EIF4B eukaryotic translation initiation factor 4B 0.0333472
CAPRIN1 cell cycle associated protein 1 0.0331172
IPO5 importin 5 0.0329937
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0328925
SND1 staphylococcal nuclease and tudor domain containing 1 0.0328086
MSI2 musashi RNA-binding protein 2 0.0328048
DST dystonin 0.0325921
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0322993
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0322576
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0321732
NUP58 nucleoporin 58 0.0319184
FAR1 fatty acyl CoA reductase 1 0.0317687
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.03148
TNS3 tensin 3 0.0311824
PUM3 pumilio RNA binding family member 3 0.0310874
PLEC plectin 0.0310363
OLA1 Obg-like ATPase 1 0.0308055
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0307184
PHF14 PHD finger protein 14 0.0304422
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0303552
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.0301062
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0297712
MACF1 microtubule-actin crosslinking factor 1 0.0297162
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0293673
ANKRD17 ankyrin repeat domain 17 0.0293163
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0289816
DIAPH2 diaphanous-related formin 2 0.0288758
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.028737
ATP13A3 ATPase type 13A3 0.028388
ANKRD10 ankyrin repeat domain 10 0.0282464
USP34 ubiquitin specific peptidase 34 0.028232
EEF2 eukaryotic translation elongation factor 2 0.0282263
PRKCA protein kinase C, alpha 0.0281893
ZEB1 zinc finger E-box binding homeobox 1 0.0281314
USP9X ubiquitin specific peptidase 9, X-linked 0.0273065
PTK2 protein tyrosine kinase 2 0.0272463
ANLN anillin, actin binding protein 0.0272265
HDAC4 histone deacetylase 4 0.0271889
FNDC3A fibronectin type III domain containing 3A 0.0269796
TARS1 threonyl-tRNA synthetase 1 0.026789
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0267382
APP amyloid beta (A4) precursor protein 0.0265978
EWSR1 EWS RNA-binding protein 1 0.0263962
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0258584
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.025724
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0256083
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0254853
FLNB filamin B, beta 0.025469
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0254265
TAS2R14 taste receptor, type 2, member 14 0.0253457

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.217633
RPS6 ribosomal protein S6 -0.162562
TPT1 tumor protein, translationally-controlled 1 -0.129902
TMSB10 thymosin beta 10 -0.129268
RPL35A ribosomal protein L35a -0.111044
PTMA prothymosin, alpha -0.0980904
RPS3 ribosomal protein S3 -0.0892725
RPLP1 ribosomal protein, large, P1 -0.0851021
RPS19 ribosomal protein S19 -0.0830531
RPS8 ribosomal protein S8 -0.0808156
RPLP2 ribosomal protein, large, P2 -0.0791566
MT2A metallothionein 2A -0.0714016
RPL26 ribosomal protein L26 -0.0706555
RPL23 ribosomal protein L23 -0.0693712
RPS13 ribosomal protein S13 -0.0692877
FTL ferritin, light polypeptide -0.0680445
RPL19 ribosomal protein L19 -0.0673094
RPL12 ribosomal protein L12 -0.0646014
RPL31 ribosomal protein L31 -0.0636137
RPL37A ribosomal protein L37a -0.0634741
VIM vimentin -0.058822
RPS27A ribosomal protein S27a -0.0574056
RPL11 ribosomal protein L11 -0.0562672
RPS23 ribosomal protein S23 -0.0546192
AKAP9 A kinase (PRKA) anchor protein 9 -0.0543496
RPS12 ribosomal protein S12 -0.053203
KRT18 keratin 18, type I -0.0527279
EGR1 early growth response 1 -0.0510872
RPL36 ribosomal protein L36 -0.050164
ACTG1 actin gamma 1 -0.0485233
RPS29 ribosomal protein S29 -0.0467255
RPS25 ribosomal protein S25 -0.0465328
RPL36A ribosomal protein L36a -0.0456365
RPS14 ribosomal protein S14 -0.0456072
RPS11 ribosomal protein S11 -0.0450958
RPL9 ribosomal protein L9 -0.0447726
RPS24 ribosomal protein S24 -0.0438517
RPL28 ribosomal protein L28 -0.0433976
RPS21 ribosomal protein S21 -0.0417583
RPS17 ribosomal protein S17 -0.0413821
RPS5 ribosomal protein S5 -0.041254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0409422
PERP PERP, TP53 apoptosis effector -0.0407452
LOC102724023 ES1 protein homolog, mitochondrial -0.0405989
EIF1 eukaryotic translation initiation factor 1 -0.0405417
RPL34 ribosomal protein L34 -0.0402695
GCC2 GRIP and coiled-coil domain containing 2 -0.0390964
RPL8 ribosomal protein L8 -0.0389442
RPL5 ribosomal protein L5 -0.0377943
RPLP0 ribosomal protein, large, P0 -0.0373343
RPL13A ribosomal protein L13a -0.0372021
RPL32 ribosomal protein L32 -0.0370086
OXR1 oxidation resistance 1 -0.0369973
RPS16 ribosomal protein S16 -0.0364793
RPS15 ribosomal protein S15 -0.0355739
RACK1 receptor for activated C kinase 1 -0.0345629
RPL35 ribosomal protein L35 -0.0345383
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0337263
NKD1 naked cuticle homolog 1 (Drosophila) -0.0327651
RPL18 ribosomal protein L18 -0.0325006
CCND1 cyclin D1 -0.0323343
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0318909
TPI1 triosephosphate isomerase 1 -0.0318234
RPL38 ribosomal protein L38 -0.0316138
DUSP6 dual specificity phosphatase 6 -0.0315612
RPL27A ribosomal protein L27a -0.0313855
S100A10 S100 calcium binding protein A10 -0.0312813
MAML2 mastermind-like 2 (Drosophila) -0.0305227
H3-3B H3.3 histone B -0.0297958
MYL12B myosin, light chain 12B, regulatory -0.029329
RPS27 ribosomal protein S27 -0.0292492
RPS10 ribosomal protein S10 -0.0291632
RPS4X ribosomal protein S4, X-linked -0.0291597
RPL7A ribosomal protein L7a -0.0279653
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0278547
ZBTB20 zinc finger and BTB domain containing 20 -0.0276167
S100A6 S100 calcium binding protein A6 -0.027094
KRT8 keratin 8, type II -0.0264697
PROX1 prospero homeobox 1 -0.0263706
RPL7 ribosomal protein L7 -0.0263467
KIZ kizuna centrosomal protein -0.0258085
TXNIP thioredoxin interacting protein -0.0257921
EZR ezrin -0.0256652
B2M beta-2-microglobulin -0.0255647
ZMYND8 zinc finger, MYND-type containing 8 -0.0254701
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0254575
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0253746
TNRC6B trinucleotide repeat containing 6B -0.0253125
TPM4 tropomyosin 4 -0.0252254
RPS20 ribosomal protein S20 -0.0251572
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0251295
SOX4 SRY (sex determining region Y)-box 4 -0.0251118
PFN1 profilin 1 -0.0251038
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0245291
KRT19 keratin 19, type I -0.0244375
UBB ubiquitin B -0.024427
RPL37 ribosomal protein L37 -0.0243453
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0236929
RPL27 ribosomal protein L27 -0.0236769
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0235885