c-Kit-IN-1_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.140085
SOD2 superoxide dismutase 2, mitochondrial 0.12234
FN1 fibronectin 1 0.121584
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.11088
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0998156
TRIO trio Rho guanine nucleotide exchange factor 0.0885095
SPAG9 sperm associated antigen 9 0.0799406
FAM13A family with sequence similarity 13, member A 0.0743318
DST dystonin 0.0736346
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0729442
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0725466
JARID2 jumonji, AT rich interactive domain 2 0.0685094
NAMPT nicotinamide phosphoribosyltransferase 0.0677414
NDRG1 N-myc downstream regulated 1 0.0648367
MYH9 myosin, heavy chain 9, non-muscle 0.0633058
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0628407
FNDC3B fibronectin type III domain containing 3B 0.0609051
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0536376
NAV2 neuron navigator 2 0.053293
FMNL2 formin-like 2 0.0521206
CALU calumenin 0.0511007
CXCL8 chemokine (C-X-C motif) ligand 8 0.0506122
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0502301
GPHN gephyrin 0.0490896
STC1 stanniocalcin 1 0.0484977
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0483694
ADM adrenomedullin 0.0449952
RUNX1 runt-related transcription factor 1 0.0442072
LDHA lactate dehydrogenase A 0.04257
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.042493
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0419716
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0402922
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0399811
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0391218
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0385266
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0373115
ELL2 elongation factor, RNA polymerase II, 2 0.0365183
ZNF292 zinc finger protein 292 0.0358868
CANX calnexin 0.0358112
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0354142
HELZ helicase with zinc finger 0.0349712
AMPD3 adenosine monophosphate deaminase 3 0.0342028
NUP58 nucleoporin 58 0.0336444
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0334126
KDM3A lysine (K)-specific demethylase 3A 0.033235
PTK2 protein tyrosine kinase 2 0.0323705
BHLHE40 basic helix-loop-helix family, member e40 0.0310067
SEC24D SEC24 family member D 0.0306134
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0305921
COL8A1 collagen, type VIII, alpha 1 0.0304563
ALCAM activated leukocyte cell adhesion molecule 0.0302424
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0300832
LRRC49 leucine rich repeat containing 49 0.0300358
RLF rearranged L-myc fusion 0.0299102
MACF1 microtubule-actin crosslinking factor 1 0.0295451
FNDC3A fibronectin type III domain containing 3A 0.0291419
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0291312
GOLGA4 golgin A4 0.0290425
PTPRM protein tyrosine phosphatase, receptor type, M 0.0288973
TNPO1 transportin 1 0.0287028
ASPH aspartate beta-hydroxylase 0.0286951
ADAM9 ADAM metallopeptidase domain 9 0.0286069
ARRDC3 arrestin domain containing 3 0.0284757
ZBTB38 zinc finger and BTB domain containing 38 0.0283051
RNF145 ring finger protein 145 0.0282792
USP3 ubiquitin specific peptidase 3 0.0281619
APP amyloid beta (A4) precursor protein 0.0278714
RND3 Rho family GTPase 3 0.0278367
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0277297
PRELID2 PRELI domain containing 2 0.027514
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0271113
OGA O-GlcNAcase 0.0270841
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0268906
FNIP1 folliculin interacting protein 1 0.0268449
ZFAND3 zinc finger, AN1-type domain 3 0.0267549
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0267399
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0264914
UBA6 ubiquitin-like modifier activating enzyme 6 0.0256693
KDM2A lysine (K)-specific demethylase 2A 0.0254779
MXI1 MAX interactor 1, dimerization protein 0.025159
ANO6 anoctamin 6 0.0251498
ANK2 ankyrin 2, neuronal 0.024965
NBAS neuroblastoma amplified sequence 0.0248916
MMP12 matrix metallopeptidase 12 0.0248783
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.02479
COG6 component of oligomeric golgi complex 6 0.0245838
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0245638
MEIS1 Meis homeobox 1 0.0244739
FBN1 fibrillin 1 0.0243892
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0242763
MAP2K1 mitogen-activated protein kinase kinase 1 0.0242273
RAB1A RAB1A, member RAS oncogene family 0.0240312
CLTC clathrin, heavy chain (Hc) 0.0239253
PDGFC platelet derived growth factor C 0.0237453
DDIT4 DNA-damage-inducible transcript 4 0.0237175
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0236202
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0235318
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0233177
HIPK2 homeodomain interacting protein kinase 2 0.0232904
SUCO SUN domain containing ossification factor 0.0231532

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.140965
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11295
VIM vimentin -0.100702
RPS6 ribosomal protein S6 -0.0758354
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0728182
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0517328
NALF1 NALCN channel auxiliary factor 1 -0.0466538
RPS8 ribosomal protein S8 -0.0462265
RPS12 ribosomal protein S12 -0.0444517
HLA-B major histocompatibility complex, class I, B -0.0415764
SASH1 SAM and SH3 domain containing 1 -0.0389752
FTH1 ferritin, heavy polypeptide 1 -0.0386632
ACTG1 actin gamma 1 -0.0381776
RPL11 ribosomal protein L11 -0.0353647
RPLP1 ribosomal protein, large, P1 -0.0340503
TMSB10 thymosin beta 10 -0.033787
EGFR epidermal growth factor receptor -0.0337748
COL5A3 collagen, type V, alpha 3 -0.0332727
RPL37A ribosomal protein L37a -0.0328339
RPL31 ribosomal protein L31 -0.0325742
RPL13A ribosomal protein L13a -0.0322663
RPL12 ribosomal protein L12 -0.0315466
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0311355
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0305702
RAI14 retinoic acid induced 14 -0.0304861
RPL19 ribosomal protein L19 -0.0301808
COL6A1 collagen, type VI, alpha 1 -0.0287301
RPS3 ribosomal protein S3 -0.0278461
RPL34 ribosomal protein L34 -0.0270304
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0270098
RPL9 ribosomal protein L9 -0.026998
RPL35A ribosomal protein L35a -0.0266432
RPLP2 ribosomal protein, large, P2 -0.0266247
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0265814
RPS17 ribosomal protein S17 -0.0263742
CLMP CXADR-like membrane protein -0.026189
ADGRB3 adhesion G protein-coupled receptor B3 -0.0260942
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0251459
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0251423
RPS23 ribosomal protein S23 -0.0247351
RACK1 receptor for activated C kinase 1 -0.0244117
PRRX1 paired related homeobox 1 -0.0240265
EGR1 early growth response 1 -0.0236609
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0235001
RPS25 ribosomal protein S25 -0.0219007
B2M beta-2-microglobulin -0.0217305
RPS29 ribosomal protein S29 -0.0215384
KIAA1549L KIAA1549-like -0.0214062
RPL27 ribosomal protein L27 -0.0213973
RPS19 ribosomal protein S19 -0.0212839
RPS27A ribosomal protein S27a -0.0210914
FTL ferritin, light polypeptide -0.021032
OXR1 oxidation resistance 1 -0.0204965
MT2A metallothionein 2A -0.0202861
RPS13 ribosomal protein S13 -0.0202569
LGALS1 lectin, galactoside-binding, soluble, 1 -0.020197
RPL26 ribosomal protein L26 -0.0199909
ARHGAP24 Rho GTPase activating protein 24 -0.0197778
EIF3A eukaryotic translation initiation factor 3, subunit A -0.019483
SEPTIN11 septin 11 -0.0193619
RPL37 ribosomal protein L37 -0.0190892
RPL8 ribosomal protein L8 -0.0190658
CALD1 caldesmon 1 -0.0189319
TPT1 tumor protein, translationally-controlled 1 -0.0189168
RPL36 ribosomal protein L36 -0.0186898
SLC38A2 solute carrier family 38, member 2 -0.0185258
RPL23 ribosomal protein L23 -0.0183306
RPL36A ribosomal protein L36a -0.018065
CCDC102B coiled-coil domain containing 102B -0.0179733
ENO2 enolase 2 (gamma, neuronal) -0.0177054
RPS14 ribosomal protein S14 -0.0174583
RPS27 ribosomal protein S27 -0.0174293
MYADM myeloid-associated differentiation marker -0.0173162
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0171332
RPS21 ribosomal protein S21 -0.0170704
HMGA2 high mobility group AT-hook 2 -0.016882
RPS20 ribosomal protein S20 -0.0168242
RPL38 ribosomal protein L38 -0.0166104
PRSS23 protease, serine, 23 -0.0163793
CCND1 cyclin D1 -0.0163654
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0163621
TPM4 tropomyosin 4 -0.0163243
RPL10A ribosomal protein L10a -0.0162105
EIF1 eukaryotic translation initiation factor 1 -0.016151
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0159851
VEGFA vascular endothelial growth factor A -0.0153886
POTEF POTE ankyrin domain family, member F -0.0149636
CD44 CD44 molecule (Indian blood group) -0.0146336
RPLP0 ribosomal protein, large, P0 -0.0146141
RPL35 ribosomal protein L35 -0.0146033
ASTN2 astrotactin 2 -0.0145557
RPL28 ribosomal protein L28 -0.0145385
CD63 CD63 molecule -0.0140854
POMP proteasome maturation protein -0.0139912
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0139526
RPS15 ribosomal protein S15 -0.0138734
RPS10 ribosomal protein S10 -0.0136489
WNT2B wingless-type MMTV integration site family, member 2B -0.0134831
RPL5 ribosomal protein L5 -0.0134651
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0132916