c-Myc Gene Set

Dataset MotifMap Predicted Transcription Factor Targets
Category genomics
Type transcription factor
Description v-myc avian myelocytomatosis viral oncogene homolog|The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 4609)
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Genes

75 target genes of the c-Myc transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRA2 adhesion G protein-coupled receptor A2
AKAP8L A kinase (PRKA) anchor protein 8-like
ANKRD13B ankyrin repeat domain 13B
BCL7A B-cell CLL/lymphoma 7A
BTK Bruton agammaglobulinemia tyrosine kinase
C2CD4A C2 calcium-dependent domain containing 4A
CD2 CD2 molecule
CENPF centromere protein F, 350/400kDa
CPLX3 complexin 3
CSK c-src tyrosine kinase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DIRC2 disrupted in renal carcinoma 2
DKC1 dyskeratosis congenita 1, dyskerin
DPY19L3 dpy-19-like 3 (C. elegans)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP23 dual specificity phosphatase 23
EEF1B2 eukaryotic translation elongation factor 1 beta 2
ELAVL4 ELAV like neuron-specific RNA binding protein 4
FLAD1 flavin adenine dinucleotide synthetase 1
FLNB filamin B, beta
FOXK1 forkhead box K1
FOXN2 forkhead box N2
FOXO3 forkhead box O3
GFI1 growth factor independent 1 transcription repressor
HDAC3 histone deacetylase 3
HOXB8 homeobox B8
HSPA8 heat shock 70kDa protein 8
IER5L immediate early response 5-like
IL34 interleukin 34
IPO7 importin 7
IQGAP2 IQ motif containing GTPase activating protein 2
LARP1 La ribonucleoprotein domain family, member 1
LOC400043 uncharacterized LOC400043
LRFN5 leucine rich repeat and fibronectin type III domain containing 5
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MEST mesoderm specific transcript
MGME1 mitochondrial genome maintenance exonuclease 1
MIAT myocardial infarction associated transcript (non-protein coding)
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR142 microRNA 142
MIR2392 microRNA 2392
MIR3917 microRNA 3917
MIR4740 microRNA 4740
MIR762 microRNA 762
MRPL40 mitochondrial ribosomal protein L40
NOP56 NOP56 ribonucleoprotein
NOP58 NOP58 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUDC nudC nuclear distribution protein
OPRD1 opioid receptor, delta 1
OTP orthopedia homeobox
PA2G4 proliferation-associated 2G4, 38kDa
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRAM1 PML-RARA regulated adaptor molecule 1
PRR7 proline rich 7 (synaptic)
PTMA prothymosin, alpha
QTRT1 queuine tRNA-ribosyltransferase 1
RANBP1 RAN binding protein 1
RPL10 ribosomal protein L10
SFXN2 sideroflexin 2
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SNORA26 small nucleolar RNA, H/ACA box 26
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCOF1 Treacher Collins-Franceschetti syndrome 1
TET2 tet methylcytosine dioxygenase 2
THOP1 thimet oligopeptidase 1
TOP1 topoisomerase (DNA) I
TRIB1 tribbles pseudokinase 1
UBXN10 UBX domain protein 10
USP15 ubiquitin specific peptidase 15
ZBTB47 zinc finger and BTB domain containing 47
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF653 zinc finger protein 653