cAMP signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap. (Kyoto Encyclopedia of Genes and Genomes, hsa04024)
External Link https://www.kegg.jp/entry/hsa04024
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222 proteins participating in the cAMP signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADCY1 adenylate cyclase 1 (brain)
ADCY10 adenylate cyclase 10 (soluble)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AFDN afadin, adherens junction formation factor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMH anti-Mullerian hormone
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAD BCL2-associated agonist of cell death
BDNF brain-derived neurotrophic factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BVES blood vessel epicardial substance
C1QTNF1 C1q and tumor necrosis factor related protein 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMK4 calcium/calmodulin-dependent protein kinase IV
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHGA chromogranin A
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CLSTN1 calsyntenin 1
CNGA1 cyclic nucleotide gated channel alpha 1
CNGA2 cyclic nucleotide gated channel alpha 2
CNGA3 cyclic nucleotide gated channel alpha 3
CNGA4 cyclic nucleotide gated channel alpha 4
CNGB1 cyclic nucleotide gated channel beta 1
CNGB3 cyclic nucleotide gated channel beta 3
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD5 dopamine receptor D5
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A
EP300 E1A binding protein p300
F2R coagulation factor II (thrombin) receptor
FFAR2 free fatty acid receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
FXYD1 FXYD domain containing ion transport regulator 1
FXYD2 FXYD domain containing ion transport regulator 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GCG glucagon
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GLI1 GLI family zinc finger 1
GLI3 GLI family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAS GNAS complex locus
GPHA2 glycoprotein hormone alpha 2
GPHB5 glycoprotein hormone beta 5
GPR119 G protein-coupled receptor 119
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
HCAR1 hydroxycarboxylic acid receptor 1
HCAR2 hydroxycarboxylic acid receptor 2
HCAR3 hydroxycarboxylic acid receptor 3
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HHIP hedgehog interacting protein
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
JUN jun proto-oncogene
KCNK2 potassium channel, two pore domain subfamily K, member 2
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LIPE lipase, hormone-sensitive
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MYL9 myosin, light chain 9, regulatory
NCOA3 nuclear receptor coactivator 3
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
ORAI1 ORAI calcium release-activated calcium modulator 1
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
PDE10A phosphodiesterase 10A
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKN1 protein kinase N1
PLCE1 phospholipase C, epsilon 1
PLD2 phospholipase D2
PLN phospholamban
POMC proopiomelanocortin
POPDC2 popeye domain containing 2
POPDC3 popeye domain containing 3
PPARA peroxisome proliferator-activated receptor alpha
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCSH protein kinase C substrate 80K-H
PTCH1 patched 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOA ras homolog family member A
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RYR2 ryanodine receptor 2 (cardiac)
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2
SSTR5 somatostatin receptor 5
SUCNR1 succinate receptor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TNNI3 troponin I type 3 (cardiac)
TSHB thyroid stimulating hormone, beta
TSHR thyroid stimulating hormone receptor
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VIPR2 vasoactive intestinal peptide receptor 2