cachexia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease. (Human Phenotype Ontology, HP_0004326)
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Genes

43 genes co-occuring with the biological term cachexia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB1 adrenoceptor beta 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CIDEA cell death-inducing DFFA-like effector a
CNTF ciliary neurotrophic factor
CRP C-reactive protein, pentraxin-related
CTSB cathepsin B
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP3A cytochrome P450, family 3, subfamily A
EGR1 early growth response 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
GDF15 growth differentiation factor 15
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INHBA inhibin, beta A
INHBC inhibin, beta C
JUND jun D proto-oncogene
LEP leptin
LIF leukemia inhibitory factor
LIPE lipase, hormone-sensitive
MC4R melanocortin 4 receptor
MDK midkine (neurite growth-promoting factor 2)
MSTN myostatin
MYOG myogenin (myogenic factor 4)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NMU neuromedin U
NPPA natriuretic peptide A
NPPB natriuretic peptide B
PNPLA2 patatin-like phospholipase domain containing 2
PRKCDBP protein kinase C, delta binding protein
PTHLH parathyroid hormone-like hormone
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
TNF tumor necrosis factor
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
VEGFA vascular endothelial growth factor A