candesartan Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension. (Chemical Entities of Biological Interest Ontology, CHEBI_3347)
External Link http://ctdbase.org/detail.go?type=chem&acc=C081643
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Genes

45 genes/proteins interacting with the chemical candesartan from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR2 angiotensin II receptor, type 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAX BCL2-associated X protein
CA1 carbonic anhydrase I
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD40LG CD40 ligand
COL1A2 collagen, type I, alpha 2
CRP C-reactive protein, pentraxin-related
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
ENG endoglin
FASLG Fas ligand (TNF superfamily, member 6)
FOXO1 forkhead box O1
GCG glucagon
ICAM1 intercellular adhesion molecule 1
IL6 interleukin 6
IRS2 insulin receptor substrate 2
LEP leptin
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MMP13 matrix metallopeptidase 13
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPPA natriuretic peptide A
PLN phospholamban
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
REN renin
RYR2 ryanodine receptor 2 (cardiac)
SLC22A9 solute carrier family 22 (organic anion transporter), member 9
SMAD3 SMAD family member 3
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TNF tumor necrosis factor
TP53 tumor protein p53
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A