canonical Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Similar Terms
Downloads & Tools

Genes

347 genes co-occuring with the biological term canonical in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADGRE5 adhesion G protein-coupled receptor E5
ADIPOQ adiponectin, C1Q and collagen domain containing
AHR aryl hydrocarbon receptor
AIM1 absent in melanoma 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANTXR1 anthrax toxin receptor 1
APAF1 apoptotic peptidase activating factor 1
APP amyloid beta (A4) precursor protein
APTX aprataxin
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATRIP ATR interacting protein
AURKA aurora kinase A
AXIN1 axin 1
BAX BCL2-associated X protein
BCL10 B-cell CLL/lymphoma 10
BCL2L1 BCL2-like 1
BCL9L B-cell CLL/lymphoma 9-like
BGN biglycan
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BRCA1 breast cancer 1, early onset
BSG basigin (Ok blood group)
CAPRIN2 caprin family member 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CC2D1A coiled-coil and C2 domain containing 1A
CD1A CD1a molecule
CD2AP CD2-associated protein
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CENPA centromere protein A
CENPT centromere protein T
CENPW centromere protein W
CETN2 centrin, EF-hand protein, 2
CGA glycoprotein hormones, alpha polypeptide
CHRM3 cholinergic receptor, muscarinic 3
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHUK conserved helix-loop-helix ubiquitous kinase
CKAP2 cytoskeleton associated protein 2
CLOCK clock circadian regulator
CLU clusterin
COMMD1 copper metabolism (Murr1) domain containing 1
CREBBP CREB binding protein
CRYAB crystallin, alpha B
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CTHRC1 collagen triple helix repeat containing 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK3 death-associated protein kinase 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DLD dihydrolipoamide dehydrogenase
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
DPF2 D4, zinc and double PHD fingers family 2
DPP4 dipeptidyl-peptidase 4
DPP8 dipeptidyl-peptidase 8
DPP9 dipeptidyl-peptidase 9
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
DROSHA drosha, ribonuclease type III
DUX4L1 double homeobox 4 like 1
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EGR1 early growth response 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EPHA4 EPH receptor A4
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F2RL2 coagulation factor II (thrombin) receptor-like 2
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBLN5 fibulin 5
FGFR1 fibroblast growth factor receptor 1
FGG fibrinogen gamma chain
FLCN folliculin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA2 forkhead box A2
FOXQ1 forkhead box Q1
FSHR follicle stimulating hormone receptor
FZD1 frizzled class receptor 1
FZD2 frizzled class receptor 2
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GDF5 growth differentiation factor 5
GEMIN4 gem (nuclear organelle) associated protein 4
GJA1 gap junction protein, alpha 1, 43kDa
GLI1 GLI family zinc finger 1
GPC6 glypican 6
GSK3B glycogen synthase kinase 3 beta
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HNF4A hepatocyte nuclear factor 4, alpha
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSF1 heat shock transcription factor 1
HSF4 heat shock transcription factor 4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL23R interleukin 23 receptor
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
IRF3 interferon regulatory factor 3
JADE1 jade family PHD finger 1
JAG1 jagged 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KISS1 KiSS-1 metastasis-suppressor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMA2 laminin, alpha 2
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRP1 low density lipoprotein receptor-related protein 1
LRP10 low density lipoprotein receptor-related protein 10
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
LZTS2 leucine zipper, putative tumor suppressor 2
MALT1 MALT1 paracaspase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MFN1 mitofusin 1
MFN2 mitofusin 2
MIR106B microRNA 106b
MIR122 microRNA 122
MIR17 microRNA 17
MIR34A microRNA 34a
MMP2 matrix metallopeptidase 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha
NCK1 NCK adaptor protein 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIPBL Nipped-B homolog (Drosophila)
NLK nemo-like kinase
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH4 notch 4
NPHP4 nephronophthisis 4
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRP1 neuropilin 1
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1
ORAI1 ORAI calcium release-activated calcium modulator 1
ORC1 origin recognition complex, subunit 1
OSTM1 osteopetrosis associated transmembrane protein 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PARK2 parkin RBR E3 ubiquitin protein ligase
PARL presenilin associated, rhomboid-like
PAX3 paired box 3
PCDHA@ protocadherin alpha cluster, complex locus
PCDHB@ protocadherin beta cluster
PCDHG@ protocadherin gamma cluster
PCOLCE procollagen C-endopeptidase enhancer
PDE12 phosphodiesterase 12
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PER1 period circadian clock 1
PI4K2B phosphatidylinositol 4-kinase type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PINK1 PTEN induced putative kinase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLG plasminogen
PLK1 polo-like kinase 1
PLN phospholamban
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKCD protein kinase C, delta
PROK1 prokineticin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTCHD4 patched domain containing 4
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTK2 protein tyrosine kinase 2
PTK7 protein tyrosine kinase 7 (inactive)
PXN paxillin
RAB7A RAB7A, member RAS oncogene family
RAP1A RAP1A, member of RAS oncogene family
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS3 regulator of G-protein signaling 3
RHOXF2 Rhox homeobox family, member 2
RIPK4 receptor-interacting serine-threonine kinase 4
RNF11 ring finger protein 11
RNF185 ring finger protein 185
ROR2 receptor tyrosine kinase-like orphan receptor 2
RORC RAR-related orphan receptor C
RSPO2 R-spondin 2
S100A4 S100 calcium binding protein A4
SALL1 spalt-like transcription factor 1
SAMD9 sterile alpha motif domain containing 9
SELL selectin L
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SF3A3 splicing factor 3a, subunit 3, 60kDa
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SFRP5 secreted frizzled-related protein 5
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHH sonic hedgehog
SIRT6 sirtuin 6
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMYD3 SET and MYND domain containing 3
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SOST sclerostin
SOX1 SRY (sex determining region Y)-box 1
SOX17 SRY (sex determining region Y)-box 17
SP1 Sp1 transcription factor
SPATS1 spermatogenesis associated, serine-rich 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIM1 stromal interaction molecule 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO2 small ubiquitin-like modifier 2
SYK spleen tyrosine kinase
SYVN1 synovial apoptosis inhibitor 1, synoviolin
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBP TATA box binding protein
TBPL2 TATA box binding protein like 2
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDG thymine-DNA glycosylase
TERC telomerase RNA component
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TJP1 tight junction protein 1
TLX3 T-cell leukemia homeobox 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNIK TRAF2 and NCK interacting kinase
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC2 trafficking protein particle complex 2
TRIM33 tripartite motif containing 33
TRK-TTT3-3 transfer RNA-Lys (TTT) 3-3
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TSC22D4 TSC22 domain family, member 4
TTK TTK protein kinase
TWIST1 twist family bHLH transcription factor 1
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
VAMP8 vesicle-associated membrane protein 8
VDAC1 voltage-dependent anion channel 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VLDLR very low density lipoprotein receptor
VTI1B vesicle transport through interaction with t-SNAREs 1B
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
WISP2 WNT1 inducible signaling pathway protein 2
WNK1 WNK lysine deficient protein kinase 1
WNK2 WNK lysine deficient protein kinase 2
WNT1 wingless-type MMTV integration site family, member 1
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1