canrenoic acid-2228 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the canrenoic acid-2228 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADGRB2 adhesion G protein-coupled receptor B2
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ASIC4 acid sensing (proton gated) ion channel family member 4
ATG10 autophagy related 10
BAIAP3 BAI1-associated protein 3
BIN1 bridging integrator 1
C1ORF54 chromosome 1 open reading frame 54
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CD47 CD47 molecule
CEP41 centrosomal protein 41kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHM choroideremia (Rab escort protein 1)
CHN2 chimerin 2
CLIC5 chloride intracellular channel 5
CLTA clathrin, light chain A
COPZ2 coatomer protein complex, subunit zeta 2
CPED1 cadherin-like and PC-esterase domain containing 1
CPLX2 complexin 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DNAH7 dynein, axonemal, heavy chain 7
DOCK5 dedicator of cytokinesis 5
DOK4 docking protein 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EDN1 endothelin 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FAM46C family with sequence similarity 46, member C
FGFBP1 fibroblast growth factor binding protein 1
GGT1 gamma-glutamyltransferase 1
GNG13 guanine nucleotide binding protein (G protein), gamma 13
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HBEGF heparin-binding EGF-like growth factor
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HFE hemochromatosis
HIC2 hypermethylated in cancer 2
IL2RB interleukin 2 receptor, beta
IMPG2 interphotoreceptor matrix proteoglycan 2
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KAT5 K(lysine) acetyltransferase 5
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLHL29 kelch-like family member 29
LAMP1 lysosomal-associated membrane protein 1
LGALS8 lectin, galactoside-binding, soluble, 8
LOC642236 FSHD region gene 1 pseudogene
LRP12 low density lipoprotein receptor-related protein 12
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA5 melanoma antigen family A5
MAPK7 mitogen-activated protein kinase 7
MOCS1 molybdenum cofactor synthesis 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MVB12B multivesicular body subunit 12B
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP2L1 NEDD4 binding protein 2-like 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NF2 neurofibromin 2 (merlin)
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NME5 NME/NM23 family member 5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHA5 protocadherin alpha 5
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCD1 phospholipase C, delta 1
POFUT1 protein O-fucosyltransferase 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRPH2 peripherin 2 (retinal degeneration, slow)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
QKI QKI, KH domain containing, RNA binding
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A8 S100 calcium binding protein A8
SH3GL3 SH3-domain GRB2-like 3
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SMIM14 small integral membrane protein 14
STOML1 stomatin (EPB72)-like 1
SULT4A1 sulfotransferase family 4A, member 1
SZT2 seizure threshold 2 homolog (mouse)
TBL1Y transducin (beta)-like 1, Y-linked
TBX3 T-box 3
TBXA2R thromboxane A2 receptor
TCEAL2 transcription elongation factor A (SII)-like 2
THRB thyroid hormone receptor, beta
TM4SF4 transmembrane 4 L six family member 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSC22D2 TSC22 domain family, member 2
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
WDR55 WD repeat domain 55
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTG2 actin, gamma 2, smooth muscle, enteric
AMPD1 adenosine monophosphate deaminase 1
ANKRD7 ankyrin repeat domain 7
BATF basic leucine zipper transcription factor, ATF-like
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC71 coiled-coil domain containing 71
CCP110 centriolar coiled coil protein 110kDa
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79B CD79b molecule, immunoglobulin-associated beta
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK3 cyclin-dependent kinase 3
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDON cell adhesion associated, oncogene regulated
CHKB choline kinase beta
CHST10 carbohydrate sulfotransferase 10
CIC capicua transcriptional repressor
CLCN6 chloride channel, voltage-sensitive 6
CNGB3 cyclic nucleotide gated channel beta 3
CSF1R colony stimulating factor 1 receptor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGAT1 diacylglycerol O-acyltransferase 1
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
EFCAB2 EF-hand calcium binding domain 2
EXD3 exonuclease 3'-5' domain containing 3
FAM160B2 family with sequence similarity 160, member B2
FAM192A family with sequence similarity 192, member A
FFAR2 free fatty acid receptor 2
FKBP5 FK506 binding protein 5
FLJ11710 uncharacterized protein FLJ11710
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
GAN gigaxonin
GATA4 GATA binding protein 4
GJA9 gap junction protein, alpha 9, 59kDa
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR157 G protein-coupled receptor 157
GSTM5 glutathione S-transferase mu 5
HIST1H2AK histone cluster 1, H2ak
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
INPP1 inositol polyphosphate-1-phosphatase
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA0754 KIAA0754
KRT15 keratin 15, type I
LAMA3 laminin, alpha 3
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRP2 low density lipoprotein receptor-related protein 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MRPL41 mitochondrial ribosomal protein L41
MYOZ1 myozenin 1
N4BP3 NEDD4 binding protein 3
NHEJ1 nonhomologous end-joining factor 1
NKX3-2 NK3 homeobox 2
NRSN2 neurensin 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PICK1 protein interacting with PRKCA 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLAC1 placenta-specific 1
PQLC2 PQ loop repeat containing 2
RABL6 RAB, member RAS oncogene family-like 6
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNF39 ring finger protein 39
RPGRIP1L RPGRIP1-like
RUNDC3B RUN domain containing 3B
SAYSD1 SAYSVFN motif domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC14L5 SEC14-like 5 (S. cerevisiae)
SLC12A8 solute carrier family 12, member 8
SPON2 spondin 2, extracellular matrix protein
STAB2 stabilin 2
STARD3 StAR-related lipid transfer (START) domain containing 3
SYBU syntabulin (syntaxin-interacting)
SYNC syncoilin, intermediate filament protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFF2 trefoil factor 2
TICAM1 toll-like receptor adaptor molecule 1
TLR5 toll-like receptor 5
TMEM115 transmembrane protein 115
TMPRSS4 transmembrane protease, serine 4
TNS2 tensin 2
TPCN1 two pore segment channel 1
TSPAN2 tetraspanin 2
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
WNT10B wingless-type MMTV integration site family, member 10B
XDH xanthine dehydrogenase
ZBTB22 zinc finger and BTB domain containing 22
ZNF329 zinc finger protein 329
ZNF37BP zinc finger protein 37B, pseudogene
ZNF442 zinc finger protein 442
ZNF701 zinc finger protein 701
Funding