canrenoic acid-6783 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the canrenoic acid-6783 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALOX15 arachidonate 15-lipoxygenase
AMPD1 adenosine monophosphate deaminase 1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
AQP4 aquaporin 4
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BAIAP3 BAI1-associated protein 3
BBS9 Bardet-Biedl syndrome 9
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCL27 chemokine (C-C motif) ligand 27
CCL7 chemokine (C-C motif) ligand 7
CD40 CD40 molecule, TNF receptor superfamily member 5
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK6 cyclin-dependent kinase 6
CEP250 centrosomal protein 250kDa
CHKB choline kinase beta
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLTA clathrin, light chain A
CSNK1G1 casein kinase 1, gamma 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DCTN1 dynactin 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ERCC2 excision repair cross-complementation group 2
ERO1L ERO1-like (S. cerevisiae)
ETV6 ets variant 6
FASLG Fas ligand (TNF superfamily, member 6)
FBXL7 F-box and leucine-rich repeat protein 7
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FLNC filamin C, gamma
FOXO4 forkhead box O4
GHRHR growth hormone releasing hormone receptor
GJA8 gap junction protein, alpha 8, 50kDa
GPR21 G protein-coupled receptor 21
GRIK5 glutamate receptor, ionotropic, kainate 5
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HFE hemochromatosis
HIST1H1T histone cluster 1, H1t
HOXA10 homeobox A10
ICOSLG inducible T-cell co-stimulator ligand
IGF2-AS IGF2 antisense RNA
IGHM immunoglobulin heavy constant mu
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOXL2 lysyl oxidase-like 2
LPCAT4 lysophosphatidylcholine acyltransferase 4
LPPR2 lipid phosphate phosphatase-related protein type 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MCAM melanoma cell adhesion molecule
MEG3 maternally expressed 3 (non-protein coding)
MORN1 MORN repeat containing 1
MR1 major histocompatibility complex, class I-related
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEURL1 neuralized E3 ubiquitin protein ligase 1
NRSN2 neurensin 2
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PCNXL2 pecanex-like 2 (Drosophila)
PGAM2 phosphoglycerate mutase 2 (muscle)
PHEX phosphate regulating endopeptidase homolog, X-linked
PIDD1 p53-induced death domain protein 1
PLIN2 perilipin 2
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKCA protein kinase C, alpha
PRR4 proline rich 4 (lacrimal)
PSD3 pleckstrin and Sec7 domain containing 3
PSD4 pleckstrin and Sec7 domain containing 4
PTAFR platelet-activating factor receptor
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RTEL1 regulator of telomere elongation helicase 1
RUSC2 RUN and SH3 domain containing 2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SIVA1 SIVA1, apoptosis-inducing factor
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
TBC1D2 TBC1 domain family, member 2
TLDC1 TBC/LysM-associated domain containing 1
TLR8 toll-like receptor 8
TMPRSS4 transmembrane protease, serine 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOP3B topoisomerase (DNA) III beta
UBTD1 ubiquitin domain containing 1
VASH2 vasohibin 2
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WAPAL wings apart-like homolog (Drosophila)
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
ZC3H7B zinc finger CCCH-type containing 7B
ZNF280A zinc finger protein 280A

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCY6 adenylate cyclase 6
ADGRE5 adhesion G protein-coupled receptor E5
ARC activity-regulated cytoskeleton-associated protein
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB1 arrestin, beta 1
AUH AU RNA binding protein/enoyl-CoA hydratase
AXIN1 axin 1
AZI2 5-azacytidine induced 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAX BCL2-associated X protein
BPGM 2,3-bisphosphoglycerate mutase
C12ORF4 chromosome 12 open reading frame 4
C6ORF47 chromosome 6 open reading frame 47
CASD1 CAS1 domain containing 1
CCP110 centriolar coiled coil protein 110kDa
CD302 CD302 molecule
CDC73 cell division cycle 73
CENPT centromere protein T
CRY2 cryptochrome circadian clock 2
DGAT1 diacylglycerol O-acyltransferase 1
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAF2 ELL associated factor 2
ELOVL4 ELOVL fatty acid elongase 4
FAAH fatty acid amide hydrolase
FAM114A2 family with sequence similarity 114, member A2
FMO4 flavin containing monooxygenase 4
GLB1L2 galactosidase, beta 1-like 2
H2AFJ H2A histone family, member J
HAUS6 HAUS augmin-like complex, subunit 6
HCFC2 host cell factor C2
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HOXC8 homeobox C8
IFI35 interferon-induced protein 35
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IREB2 iron-responsive element binding protein 2
ISG15 ISG15 ubiquitin-like modifier
KDM8 lysine (K)-specific demethylase 8
KIAA0556 KIAA0556
KLK5 kallikrein-related peptidase 5
KRT8P12 keratin 8 pseudogene 12
LHX6 LIM homeobox 6
LOC100287590 uncharacterized LOC100287590
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LZTFL1 leucine zipper transcription factor-like 1
MANEA mannosidase, endo-alpha
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MCC mutated in colorectal cancers
MEIS3P1 Meis homeobox 3 pseudogene 1
MFAP2 microfibrillar-associated protein 2
MFSD11 major facilitator superfamily domain containing 11
MGC12488
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MYO1D myosin ID
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NIPAL2 NIPA-like domain containing 2
NNAT neuronatin
NUBPL nucleotide binding protein-like
OSMR oncostatin M receptor
PCDHGB5 protocadherin gamma subfamily B, 5
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G12A phospholipase A2, group XIIA
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLXNA3 plexin A3
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POTEKP POTE ankyrin domain family, member K, pseudogene
PRPH peripherin
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SHARPIN SHANK-associated RH domain interactor
SKA1 spindle and kinetochore associated complex subunit 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLIT2 slit homolog 2 (Drosophila)
SMR3A submaxillary gland androgen regulated protein 3A
SNHG20 small nucleolar RNA host gene 20
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TLN1 talin 1
TM9SF3 transmembrane 9 superfamily member 3
TNS2 tensin 2
TRIM5 tripartite motif containing 5
TSPAN1 tetraspanin 1
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
USP36 ubiquitin specific peptidase 36
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZFP30 ZFP30 zinc finger protein
ZNF227 zinc finger protein 227
ZNF273 zinc finger protein 273
ZNF365 zinc finger protein 365
ZNF408 zinc finger protein 408
ZNF428 zinc finger protein 428
ZNF516 zinc finger protein 516
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675
Funding