captopril-1488 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the captopril-1488 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACTN2 actinin, alpha 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDOB aldolase B, fructose-bisphosphate
ALPK1 alpha-kinase 1
ANKRD40 ankyrin repeat domain 40
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP9 aquaporin 9
ARC activity-regulated cytoskeleton-associated protein
ARHGAP26 Rho GTPase activating protein 26
ARHGAP33 Rho GTPase activating protein 33
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARMC4 armadillo repeat containing 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BIN1 bridging integrator 1
C4ORF29 chromosome 4 open reading frame 29
CCL22 chemokine (C-C motif) ligand 22
CCNO cyclin O
CD83 CD83 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEP104 centrosomal protein 104kDa
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN11 claudin 11
CLEC11A C-type lectin domain family 11, member A
CLSTN3 calsyntenin 3
CUZD1 CUB and zona pellucida-like domains 1
CXADR coxsackie virus and adenovirus receptor
CYHR1 cysteine/histidine-rich 1
DEFB126 defensin, beta 126
DNAL4 dynein, axonemal, light chain 4
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGR1 early growth response 1
EMC1 ER membrane protein complex subunit 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EXTL3 exostosin-like glycosyltransferase 3
FBXL7 F-box and leucine-rich repeat protein 7
FDPS farnesyl diphosphate synthase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GADD45G growth arrest and DNA-damage-inducible, gamma
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GLIPR1 GLI pathogenesis-related 1
GPATCH3 G patch domain containing 3
GREB1 growth regulation by estrogen in breast cancer 1
HMGA1 high mobility group AT-hook 1
HOXB2 homeobox B2
IFT54 intraflagellar transport 54
IGF1R insulin-like growth factor 1 receptor
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IRF2BP1 interferon regulatory factor 2 binding protein 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JRK Jrk homolog (mouse)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK12 potassium channel, two pore domain subfamily K, member 12
LRRC23 leucine rich repeat containing 23
LYPD1 LY6/PLAUR domain containing 1
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAIP NLR family, apoptosis inhibitory protein
NCR3 natural cytotoxicity triggering receptor 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NF1 neurofibromin 1
NGLY1 N-glycanase 1
NIPAL2 NIPA-like domain containing 2
OASL 2'-5'-oligoadenylate synthetase-like
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OTUD4 OTU deubiquitinase 4
PADI1 peptidyl arginine deiminase, type I
PKNOX1 PBX/knotted 1 homeobox 1
PLAGL1 pleiomorphic adenoma gene-like 1
PODNL1 podocan-like 1
POFUT1 protein O-fucosyltransferase 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RGS7 regulator of G-protein signaling 7
RHBG Rh family, B glycoprotein (gene/pseudogene)
RHEB Ras homolog enriched in brain
RPGR retinitis pigmentosa GTPase regulator
RUFY3 RUN and FYVE domain containing 3
S100A8 S100 calcium binding protein A8
SCAPER S-phase cyclin A-associated protein in the ER
SCN10A sodium channel, voltage gated, type X alpha subunit
SFTPB surfactant protein B
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SPEG SPEG complex locus
SPHK2 sphingosine kinase 2
TAOK1 TAO kinase 1
TBC1D2B TBC1 domain family, member 2B
TCHH trichohyalin
TLR5 toll-like receptor 5
TMEM80 transmembrane protein 80
TPSAB1 tryptase alpha/beta 1
TRAK1 trafficking protein, kinesin binding 1
TWISTNB TWIST neighbor
WDR1 WD repeat domain 1
XDH xanthine dehydrogenase
ZNF136 zinc finger protein 136
ZNF219 zinc finger protein 219
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARRB1 arrestin, beta 1
ARSB arylsulfatase B
ATAD5 ATPase family, AAA domain containing 5
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBS7 Bardet-Biedl syndrome 7
BCL2L2 BCL2-like 2
C11ORF30 chromosome 11 open reading frame 30
C19ORF73 chromosome 19 open reading frame 73
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CIDEC cell death-inducing DFFA-like effector c
CRY2 cryptochrome circadian clock 2
CTC1 CTS telomere maintenance complex component 1
EFHD2 EF-hand domain family, member D2
EFNA3 ephrin-A3
EPPK1 epiplakin 1
FBXL2 F-box and leucine-rich repeat protein 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FLJ22184
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAMT guanidinoacetate N-methyltransferase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GID4 GID complex subunit 4
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HIST1H2AJ histone cluster 1, H2aj
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IDI2-AS1 IDI2 antisense RNA 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL17RA interleukin 17 receptor A
IL22 interleukin 22
INF2 inverted formin, FH2 and WH2 domain containing
IPO8 importin 8
IRF2 interferon regulatory factor 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIN7A lin-7 homolog A (C. elegans)
LINC00339 long intergenic non-protein coding RNA 339
LOC257152 uncharacterized LOC257152
LRP3 low density lipoprotein receptor-related protein 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP2 latent transforming growth factor beta binding protein 2
MAST3 microtubule associated serine/threonine kinase 3
MCC mutated in colorectal cancers
MEIS2 Meis homeobox 2
MFSD11 major facilitator superfamily domain containing 11
MYO1D myosin ID
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PACS1 phosphofurin acidic cluster sorting protein 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PGPEP1 pyroglutamyl-peptidase I
PHC1 polyhomeotic homolog 1 (Drosophila)
PLD2 phospholipase D2
PMCH pro-melanin-concentrating hormone
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRKCE protein kinase C, epsilon
PRMT7 protein arginine methyltransferase 7
PRPH peripherin
PTPRU protein tyrosine phosphatase, receptor type, U
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SIRT6 sirtuin 6
SKA1 spindle and kinetochore associated complex subunit 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SNX16 sorting nexin 16
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STRN4 striatin, calmodulin binding protein 4
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAZ tafazzin
TCTN2 tectonic family member 2
TDRD1 tudor domain containing 1
TLN1 talin 1
TMEM62 transmembrane protein 62
TRAIP TRAF interacting protein
USP19 ubiquitin specific peptidase 19
VASH1 vasohibin 1
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
XK X-linked Kx blood group
ZBTB22 zinc finger and BTB domain containing 22
ZBTB48 zinc finger and BTB domain containing 48
ZC3H3 zinc finger CCCH-type containing 3
ZNF211 zinc finger protein 211
ZNF248 zinc finger protein 248
ZNF254 zinc finger protein 254
ZNF34 zinc finger protein 34
ZNF350 zinc finger protein 350
ZNF442 zinc finger protein 442
ZNF654 zinc finger protein 654
ZNF787 zinc finger protein 787