carbenoxolone-3353 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the carbenoxolone-3353 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
AHNAK2 AHNAK nucleoprotein 2
APC adenomatous polyposis coli
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATF7IP activating transcription factor 7 interacting protein
ATN1 atrophin 1
B9D2 B9 protein domain 2
BCL3 B-cell CLL/lymphoma 3
BMP1 bone morphogenetic protein 1
C1ORF54 chromosome 1 open reading frame 54
CALML5 calmodulin-like 5
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARD9 caspase recruitment domain family, member 9
CD48 CD48 molecule
CDA cytidine deaminase
CEP41 centrosomal protein 41kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC4A C-type lectin domain family 4, member A
CTNS cystinosin, lysosomal cystine transporter
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
EFR3B EFR3 homolog B (S. cerevisiae)
ELSPBP1 epididymal sperm binding protein 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERCC2 excision repair cross-complementation group 2
EXT1 exostosin glycosyltransferase 1
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FBXO21 F-box protein 21
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF2 fibroblast growth factor 2 (basic)
FHL1 four and a half LIM domains 1
FKBP10 FK506 binding protein 10, 65 kDa
FLNC filamin C, gamma
GAB1 GRB2-associated binding protein 1
GK3P glycerol kinase 3 pseudogene
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GRM6 glutamate receptor, metabotropic 6
GRM8 glutamate receptor, metabotropic 8
GRPR gastrin-releasing peptide receptor
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HDLBP high density lipoprotein binding protein
HSF1 heat shock transcription factor 1
ICOSLG inducible T-cell co-stimulator ligand
IL11 interleukin 11
IL24 interleukin 24
INHBA inhibin, beta A
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KALRN kalirin, RhoGEF kinase
KRT15 keratin 15, type I
LAMB4 laminin, beta 4
LAX1 lymphocyte transmembrane adaptor 1
LHX3 LIM homeobox 3
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MRPS12 mitochondrial ribosomal protein S12
MYOF myoferlin
NAT6 N-acetyltransferase 6 (GCN5-related)
NF2 neurofibromin 2 (merlin)
NME5 NME/NM23 family member 5
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
OLFM1 olfactomedin 1
OMG oligodendrocyte myelin glycoprotein
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PHF20L1 PHD finger protein 20-like 1
PLLP plasmolipin
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POMT2 protein-O-mannosyltransferase 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RERE arginine-glutamic acid dipeptide (RE) repeats
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RRBP1 ribosome binding protein 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAFB scaffold attachment factor B
SELL selectin L
SHOX2 short stature homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS3 suppressor of cytokine signaling 3
SORBS1 sorbin and SH3 domain containing 1
SSX1 synovial sarcoma, X breakpoint 1
STAB2 stabilin 2
STX7 syntaxin 7
SVIL supervillin
TFEB transcription factor EB
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM259 transmembrane protein 259
TMEM63A transmembrane protein 63A
VIPR2 vasoactive intestinal peptide receptor 2
WFDC2 WAP four-disulfide core domain 2
WNT16 wingless-type MMTV integration site family, member 16
ZC3H13 zinc finger CCCH-type containing 13
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
APLP1 amyloid beta (A4) precursor-like protein 1
ARMCX2 armadillo repeat containing, X-linked 2
ATAT1 alpha tubulin acetyltransferase 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BMP4 bone morphogenetic protein 4
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCNK cyclin K
CD2AP CD2-associated protein
CDKL3 cyclin-dependent kinase-like 3
CLGN calmegin
CLIP4 CAP-GLY domain containing linker protein family, member 4
CRIP1 cysteine-rich protein 1 (intestinal)
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DCBLD2 discoidin, CUB and LCCL domain containing 2
DGAT1 diacylglycerol O-acyltransferase 1
DNAL4 dynein, axonemal, light chain 4
DOC2A double C2-like domains, alpha
DOK2 docking protein 2, 56kDa
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EMID1 EMI domain containing 1
EXO5 exonuclease 5
EXOC6B exocyst complex component 6B
FAM204A family with sequence similarity 204, member A
FANCE Fanconi anemia, complementation group E
FGF23 fibroblast growth factor 23
FOSL1 FOS-like antigen 1
FOXK2 forkhead box K2
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GAMT guanidinoacetate N-methyltransferase
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPATCH3 G patch domain containing 3
GPR19 G protein-coupled receptor 19
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HHLA3 HERV-H LTR-associating 3
HIST1H2AI histone cluster 1, H2ai
HIST1H2AL histone cluster 1, H2al
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DMB major histocompatibility complex, class II, DM beta
HOXC5 homeobox C5
HSPA1L heat shock 70kDa protein 1-like
IL22 interleukin 22
INHBE inhibin, beta E
IRF6 interferon regulatory factor 6
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCTD17 potassium channel tetramerization domain containing 17
KIF13A kinesin family member 13A
KLC2 kinesin light chain 2
LHX1 LIM homeobox 1
MALL mal, T-cell differentiation protein-like
MB myoglobin
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MYOZ3 myozenin 3
N4BP3 NEDD4 binding protein 3
NLRX1 NLR family member X1
NXPE3 neurexophilin and PC-esterase domain family, member 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAIP2B poly(A) binding protein interacting protein 2B
PLA2G3 phospholipase A2, group III
POLR1E polymerase (RNA) I polypeptide E, 53kDa
RAB30 RAB30, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RIPK4 receptor-interacting serine-threonine kinase 4
RNF122 ring finger protein 122
SAYSD1 SAYSVFN motif domain containing 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SPANXC SPANX family, member C
SPATA2L spermatogenesis associated 2-like
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON2 spondin 2, extracellular matrix protein
SPTBN2 spectrin, beta, non-erythrocytic 2
STAG3 stromal antigen 3
STIM1 stromal interaction molecule 1
SYNC syncoilin, intermediate filament protein
SYTL2 synaptotagmin-like 2
TBC1D2 TBC1 domain family, member 2
TEAD3 TEA domain family member 3
THRAP3 thyroid hormone receptor associated protein 3
TONSL tonsoku-like, DNA repair protein
TUBGCP5 tubulin, gamma complex associated protein 5
TYRP1 tyrosinase-related protein 1
UPK2 uroplakin 2
UPK3B uroplakin 3B
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VIPR1 vasoactive intestinal peptide receptor 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR33 WD repeat domain 33
WDR6 WD repeat domain 6
XAB2 XPA binding protein 2
ZBTB44 zinc finger and BTB domain containing 44
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF358 zinc finger protein 358