carbimazole-5399 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the carbimazole-5399 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACBD4 acyl-CoA binding domain containing 4
ACPP acid phosphatase, prostate
ADCK2 aarF domain containing kinase 2
ADM adrenomedullin
ANKLE2 ankyrin repeat and LEM domain containing 2
AOC2 amine oxidase, copper containing 2 (retina-specific)
ASAP1-IT1 ASAP1 intronic transcript 1
BMP1 bone morphogenetic protein 1
C1QTNF1 C1q and tumor necrosis factor related protein 1
CLCN7 chloride channel, voltage-sensitive 7
CLMN calmin (calponin-like, transmembrane)
CNN1 calponin 1, basic, smooth muscle
COMT catechol-O-methyltransferase
CTNS cystinosin, lysosomal cystine transporter
CUZD1 CUB and zona pellucida-like domains 1
DCC DCC netrin 1 receptor
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DESI2 desumoylating isopeptidase 2
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DMPK dystrophia myotonica-protein kinase
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
DSCAM Down syndrome cell adhesion molecule
EPOR erythropoietin receptor
FABP3 fatty acid binding protein 3, muscle and heart
FAM186A family with sequence similarity 186, member A
FBXO11 F-box protein 11
FBXO2 F-box protein 2
FBXO9 F-box protein 9
FHL1 four and a half LIM domains 1
FLOT1 flotillin 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GJB3 gap junction protein, beta 3, 31kDa
GP2 glycoprotein 2 (zymogen granule membrane)
HIST1H4H histone cluster 1, H4h
ICOSLG inducible T-cell co-stimulator ligand
IFT27 intraflagellar transport 27
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
LAMC2 laminin, gamma 2
LIMCH1 LIM and calponin homology domains 1
LIN7B lin-7 homolog B (C. elegans)
MAP4 microtubule-associated protein 4
MARK2 MAP/microtubule affinity-regulating kinase 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEF2D myocyte enhancer factor 2D
MKL1 megakaryoblastic leukemia (translocation) 1
NF1 neurofibromin 1
NNAT neuronatin
NOS1 nitric oxide synthase 1 (neuronal)
NOTCH4 notch 4
NRL neural retina leucine zipper
NUP188 nucleoporin 188kDa
NUP54 nucleoporin 54kDa
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAX9 paired box 9
PCDH7 protocadherin 7
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCL phosducin-like
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDGFB platelet-derived growth factor beta polypeptide
PHEX phosphate regulating endopeptidase homolog, X-linked
PHF3 PHD finger protein 3
PLCD1 phospholipase C, delta 1
POM121L2 POM121 transmembrane nucleoporin-like 2
POU4F1 POU class 4 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCI protein kinase C, iota
RHOQ ras homolog family member Q
RHOT1 ras homolog family member T1
RIOK3 RIO kinase 3
RUNX1 runt-related transcription factor 1
S100A11 S100 calcium binding protein A11
SENP7 SUMO1/sentrin specific peptidase 7
SIK3 SIK family kinase 3
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SOS2 son of sevenless homolog 2 (Drosophila)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TCP10 t-complex 10
TDRD12 tudor domain containing 12
TGFB2 transforming growth factor, beta 2
TICAM1 toll-like receptor adaptor molecule 1
TLDC1 TBC/LysM-associated domain containing 1
TMEM8B transmembrane protein 8B
TMPRSS3 transmembrane protease, serine 3
VIPR1 vasoactive intestinal peptide receptor 1
WIZ widely interspaced zinc finger motifs
ZEB1 zinc finger E-box binding homeobox 1
ZNF236 zinc finger protein 236
ZNF419 zinc finger protein 419
ZNF606 zinc finger protein 606
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ADGRG2 adhesion G protein-coupled receptor G2
ALPK1 alpha-kinase 1
APLP1 amyloid beta (A4) precursor-like protein 1
APOLD1 apolipoprotein L domain containing 1
ATF3 activating transcription factor 3
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BAGE B melanoma antigen
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
CA11 carbonic anhydrase XI
CA5BP1 carbonic anhydrase VB pseudogene 1
CD79B CD79b molecule, immunoglobulin-associated beta
CD8A CD8a molecule
CHM choroideremia (Rab escort protein 1)
CLCN2 chloride channel, voltage-sensitive 2
CNGB3 cyclic nucleotide gated channel beta 3
CPTP ceramide-1-phosphate transfer protein
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DGAT1 diacylglycerol O-acyltransferase 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DUSP13 dual specificity phosphatase 13
EFNA3 ephrin-A3
FAAH fatty acid amide hydrolase
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FCHO1 FCH domain only 1
FGGY FGGY carbohydrate kinase domain containing
FKBP10 FK506 binding protein 10, 65 kDa
FOXN2 forkhead box N2
GAS2 growth arrest-specific 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA9 gap junction protein, alpha 9, 59kDa
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H4E histone cluster 1, H4e
HOXC10 homeobox C10
HOXC5 homeobox C5
IGSF6 immunoglobulin superfamily, member 6
INPP1 inositol polyphosphate-1-phosphatase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LRP2 low density lipoprotein receptor-related protein 2
LRRC61 leucine rich repeat containing 61
MED9 mediator complex subunit 9
METTL16 methyltransferase like 16
MYL5 myosin, light chain 5, regulatory
MYOZ3 myozenin 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NDOR1 NADPH dependent diflavin oxidoreductase 1
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
NT5DC3 5'-nucleotidase domain containing 3
PCDHA6 protocadherin alpha 6
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK7 proprotein convertase subtilisin/kexin type 7
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POM121 POM121 transmembrane nucleoporin
POMT2 protein-O-mannosyltransferase 2
PORCN porcupine homolog (Drosophila)
PRF1 perforin 1 (pore forming protein)
PRR4 proline rich 4 (lacrimal)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRU protein tyrosine phosphatase, receptor type, U
QPCT glutaminyl-peptide cyclotransferase
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RPAP1 RNA polymerase II associated protein 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLIT2 slit homolog 2 (Drosophila)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOAT2 sterol O-acyltransferase 2
STK16 serine/threonine kinase 16
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBR3 transforming growth factor, beta receptor III
TMEM212 transmembrane protein 212
TNS2 tensin 2
TRIM36 tripartite motif containing 36
TTLL1 tubulin tyrosine ligase-like family member 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBTD1 ubiquitin domain containing 1
UNC119 unc-119 homolog (C. elegans)
VGF VGF nerve growth factor inducible
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF350 zinc finger protein 350
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747
ZNF768 zinc finger protein 768
ZNF804A zinc finger protein 804A