carboplatin Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
Description A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand. (Chemical Entities of Biological Interest Ontology, CHEBI_31355)
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Genes

558 genes differentially expressed following the carboplatin small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
NOS3 nitric oxide synthase 3 (endothelial cell) 11.7227
SIRT3 sirtuin 3 11.3256
GSTZ1 glutathione S-transferase zeta 1 9.19068
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 8.42107
SPP1 secreted phosphoprotein 1 7.00092
POU5F1P3 POU class 5 homeobox 1 pseudogene 3 6.48069
EGF epidermal growth factor 6.44668
DZIP3 DAZ interacting zinc finger protein 3 6.43997
CDCA4 cell division cycle associated 4 6.28238
FSD1 fibronectin type III and SPRY domain containing 1 6.20121
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.18445
TOR1B torsin family 1, member B (torsin B) 5.72788
TBP TATA box binding protein 5.71598
DCLRE1A DNA cross-link repair 1A 5.41964
CASP7 caspase 7, apoptosis-related cysteine peptidase 5.41286
ARL4D ADP-ribosylation factor-like 4D 5.37058
PKP1 plakophilin 1 5.35226
DHDDS dehydrodolichyl diphosphate synthase 5.34983
KLHL12 kelch-like family member 12 5.14086
POU5F1B POU class 5 homeobox 1B 5.12442
LIN28A lin-28 homolog A (C. elegans) 5.10433
RBM34 RNA binding motif protein 34 5.05179
GDF3 growth differentiation factor 3 5.01169
WDCP WD repeat and coiled coil containing 5.0069
KIF20A kinesin family member 20A 4.89834
LZTS1 leucine zipper, putative tumor suppressor 1 4.89214
RHD Rh blood group, D antigen 4.82297
PHC1 polyhomeotic homolog 1 (Drosophila) 4.8031
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 4.75089
MARK3 MAP/microtubule affinity-regulating kinase 3 4.66846
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 4.66183
ADGRG2 adhesion G protein-coupled receptor G2 4.65177
BST2 bone marrow stromal cell antigen 2 4.6417
MAMLD1 mastermind-like domain containing 1 4.63465
KIF23 kinesin family member 23 4.62254
NLRP2 NLR family, pyrin domain containing 2 4.56112
KIF18A kinesin family member 18A 4.55802
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) 4.53013
HOXD9 homeobox D9 4.50396
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 4.50238
PLEKHA8P1 pleckstrin homology domain containing, family A member 8 pseudogene 1 4.49812
NPY5R neuropeptide Y receptor Y5 4.45848
HAS2 hyaluronan synthase 2 4.39928
CANT1 calcium activated nucleotidase 1 4.38982
DCX doublecortin 4.37659
NUP214 nucleoporin 214kDa 4.37159
THBD thrombomodulin 4.36825
AKAP3 A kinase (PRKA) anchor protein 3 4.3479
PINK1 PTEN induced putative kinase 1 4.33182
DPPA4 developmental pluripotency associated 4 4.30778
RNF121 ring finger protein 121 4.29521
IGFBP5 insulin-like growth factor binding protein 5 4.26265
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 4.23433
ABHD6 abhydrolase domain containing 6 4.22914
BCCIP BRCA2 and CDKN1A interacting protein 4.22559
KRT36 keratin 36, type I 4.20976
DCSTAMP dendrocyte expressed seven transmembrane protein 4.20033
PRRC2B proline-rich coiled-coil 2B 4.19894
AURKC aurora kinase C 4.1919
CCRL2 chemokine (C-C motif) receptor-like 2 4.19168
CT62 cancer/testis antigen 62 4.17553
CCNB2 cyclin B2 4.17361
NANOG Nanog homeobox 4.16148
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 4.15928
PPP1R3C protein phosphatase 1, regulatory subunit 3C 4.14666
ARMCX2 armadillo repeat containing, X-linked 2 4.14013
GTPBP3 GTP binding protein 3 (mitochondrial) 4.12583
CARMIL1 capping protein regulator and myosin 1 linker 1 4.12412
ZNF814 zinc finger protein 814 4.10926
PIWIL1 piwi-like RNA-mediated gene silencing 1 4.10573
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 4.10505
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 4.10432
MAGED2 melanoma antigen family D2 4.10011
DPY19L1P1 DPY19L1 pseudogene 1 4.08957
RAB8A RAB8A, member RAS oncogene family 4.08424
KLF10 Kruppel-like factor 10 4.0803
ARHGAP44 Rho GTPase activating protein 44 4.07949
CD40 CD40 molecule, TNF receptor superfamily member 5 4.07267
GPR107 G protein-coupled receptor 107 4.06484
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 4.06377
LHFPL2 lipoma HMGIC fusion partner-like 2 4.06096
PEX5 peroxisomal biogenesis factor 5 4.00372
PTTG1IP pituitary tumor-transforming 1 interacting protein 3.98116
RNF17 ring finger protein 17 3.97747
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 3.95362
SIM1 single-minded family bHLH transcription factor 1 3.92408
KYAT1 kynurenine aminotransferase 1 3.92311
FAM234B family with sequence similarity 234 member B 3.92037
SH3BP4 SH3-domain binding protein 4 3.90779
TMSB10 thymosin beta 10 3.90662
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 3.90225
BDNF brain-derived neurotrophic factor 3.90024
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 3.9
GRP gastrin-releasing peptide 3.88748
GYPB glycophorin B (MNS blood group) 3.87449
ADPGK ADP-dependent glucokinase 3.86899
PDE7B phosphodiesterase 7B 3.85765
RNF44 ring finger protein 44 3.84481
MAPKAP1 mitogen-activated protein kinase associated protein 1 3.83664
WDHD1 WD repeat and HMG-box DNA binding protein 1 3.82514
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 3.80597
SAA4 serum amyloid A4, constitutive 3.80369
RAMP2 receptor (G protein-coupled) activity modifying protein 2 3.80176
WBP11 WW domain binding protein 11 3.79987
NAGK N-acetylglucosamine kinase 3.79313
RAB28 RAB28, member RAS oncogene family 3.79247
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 3.7881
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 3.78284
LAPTM4A lysosomal protein transmembrane 4 alpha 3.77776
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.77444
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 3.77167
CTR9 CTR9, Paf1/RNA polymerase II complex component 3.75582
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.75362
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.74152
CST8 cystatin 8 (cystatin-related epididymal specific) 3.74052
TMEM45A transmembrane protein 45A 3.73921
CNTN5 contactin 5 3.73701
STAT1 signal transducer and activator of transcription 1, 91kDa 3.7367
DSCAM Down syndrome cell adhesion molecule 3.73182
SAP30L-AS1 SAP30L antisense RNA 1 (head to head) 3.7298
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 3.7281
BMERB1 bMERB domain containing 1 3.71978
CAPRIN2 caprin family member 2 3.71961
WBP1L WW domain binding protein 1-like 3.70064
PODXL podocalyxin-like 3.68254
H2AC6 H2A clustered histone 6 3.66615
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 3.6532
KDM3A lysine (K)-specific demethylase 3A 3.64845
CTSE cathepsin E 3.64372
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.6419
ASIC1 acid sensing (proton gated) ion channel 1 3.63981
UBAC1 UBA domain containing 1 3.62908
TOR1A torsin family 1, member A (torsin A) 3.62564
IGSF3 immunoglobulin superfamily, member 3 3.62518
SIK1 salt-inducible kinase 1 3.62029
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 3.62023
CFAP44 cilia and flagella associated protein 44 3.61881
NAP1L1 nucleosome assembly protein 1-like 1 3.60913
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.60138
EFCAB11 EF-hand calcium binding domain 11 3.58741
ZPBP zona pellucida binding protein 3.58419
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 3.58379
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 3.57835
SEC23IP SEC23 interacting protein 3.57757
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 3.57398
SCGB1D2 secretoglobin, family 1D, member 2 3.5701
CDK5RAP2 CDK5 regulatory subunit associated protein 2 3.56329
CEP152 centrosomal protein 152kDa 3.56203
ADIPOR2 adiponectin receptor 2 3.5472
SSTR4 somatostatin receptor 4 3.54441
CPNE1 copine I 3.53719
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 3.5294
ANKRD26 ankyrin repeat domain 26 3.52713
GDAP1 ganglioside induced differentiation associated protein 1 3.52682
LALBA lactalbumin, alpha- 3.52417
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 3.52252
CYRIB CYFIP related Rac1 interactor B 3.51951
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 3.51109
TNC tenascin C 3.50413
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 3.5038
TSG101 tumor susceptibility 101 3.50363
DNMBP dynamin binding protein 3.50249
C10ORF88 chromosome 10 open reading frame 88 3.50177
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.49256
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 3.48656
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 3.48347
BBS4 Bardet-Biedl syndrome 4 3.48342
CYCS cytochrome c, somatic 3.47889
FXR1 fragile X mental retardation, autosomal homolog 1 3.47808
BRCA1 breast cancer 1, early onset 3.45544
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 3.44931
MED20 mediator complex subunit 20 3.44483
CLCNKB chloride channel, voltage-sensitive Kb 3.44228
BUB3 BUB3 mitotic checkpoint protein 3.43608
PDIA3 protein disulfide isomerase family A, member 3 3.43416
POT1 protection of telomeres 1 3.43285
OFD1 oral-facial-digital syndrome 1 3.42616
FAM222B family with sequence similarity 222, member B 3.42172
RHAG Rh-associated glycoprotein 3.41045
TMEM8B transmembrane protein 8B 3.40705
PMCH pro-melanin-concentrating hormone 3.40384
C1ORF105 chromosome 1 open reading frame 105 3.40371
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 3.40308
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 3.40157
TBC1D19 TBC1 domain family, member 19 3.39828
EPOR erythropoietin receptor 3.39617
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.39439
GS1-600G8.3 unknown transcript 3.39337
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 3.38982
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.38294
RABGAP1 RAB GTPase activating protein 1 3.37758
CA12 carbonic anhydrase XII 3.37608
AVIL advillin 3.368
PPT1 palmitoyl-protein thioesterase 1 3.36579
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 3.36447
FXYD2 FXYD domain containing ion transport regulator 2 3.36363
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 3.35737
SLIT1 slit homolog 1 (Drosophila) 3.35412
ESRRG estrogen-related receptor gamma 3.3484
ELF5 E74-like factor 5 (ets domain transcription factor) 3.34509
CAPG capping protein (actin filament), gelsolin-like 3.34403
OSBPL2 oxysterol binding protein-like 2 3.33874
PHLDA1 pleckstrin homology-like domain, family A, member 1 3.33279
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.32682
KDSR 3-ketodihydrosphingosine reductase 3.31607
ARMT1 acidic residue methyltransferase 1 3.30515
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 3.30267
ARPC5L actin related protein 2/3 complex, subunit 5-like 3.29969
TPTE transmembrane phosphatase with tensin homology 3.29676
P3H2 prolyl 3-hydroxylase 2 3.29475
ZNF532 zinc finger protein 532 3.28706
SUSD6 sushi domain containing 6 3.28596
SKA1 spindle and kinetochore associated complex subunit 1 3.28478
EIF3F eukaryotic translation initiation factor 3, subunit F 3.28249
TMBIM6 transmembrane BAX inhibitor motif containing 6 3.27039
LSAMP limbic system-associated membrane protein 3.26394
NPY1R neuropeptide Y receptor Y1 3.25923
EBF2 early B-cell factor 2 3.2504
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 3.24937
CRYBA4 crystallin, beta A4 3.24635
NBR1 neighbor of BRCA1 gene 1 3.24528
MIR9-1HG MIR9-1 host gene 3.23946
RNASEH2A ribonuclease H2, subunit A 3.23361
UBA5 ubiquitin-like modifier activating enzyme 5 3.23311
CST1 cystatin SN 3.22906
STC2 stanniocalcin 2 3.22447
MDRV muscular dystrophy, with rimmed vacuoles 3.22037
PARP12 poly (ADP-ribose) polymerase family, member 12 3.21659
NUP188 nucleoporin 188kDa 3.21639
TADA2A transcriptional adaptor 2A 3.21064
VAMP8 vesicle-associated membrane protein 8 3.21007
STYXL1 serine/threonine/tyrosine interacting-like 1 3.20785
TALDO1 transaldolase 1 3.20533
GGCT gamma-glutamylcyclotransferase 3.20518
ANOS1 anosmin 1 3.20365
SYCP2 synaptonemal complex protein 2 3.19799
EYA1 EYA transcriptional coactivator and phosphatase 1 3.19623
ZNF177 zinc finger protein 177 3.19523
RAB13 RAB13, member RAS oncogene family 3.19189
COQ4 coenzyme Q4 3.18554
GAN gigaxonin 3.18438
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 3.18121
MTERF4 mitochondrial transcription termination factor 4 3.17675
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 3.16765
AUH AU RNA binding protein/enoyl-CoA hydratase 3.15814
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog 3.15675
MAGEB1 melanoma antigen family B1 3.1536
FBXW2 F-box and WD repeat domain containing 2 3.15225
MXI1 MAX interactor 1, dimerization protein 3.14819
SIL1 SIL1 nucleotide exchange factor 3.14712
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 3.14436
SLC39A6 solute carrier family 39 (zinc transporter), member 6 3.14387
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.14375
DYNLT3 dynein, light chain, Tctex-type 3 3.13848
POMT2 protein-O-mannosyltransferase 2 3.13352
MAST1 microtubule associated serine/threonine kinase 1 3.13205
PTPN14 protein tyrosine phosphatase, non-receptor type 14 3.13197
MROH7 maestro heat-like repeat family member 7 3.13143
TTTY15 testis-specific transcript, Y-linked 15 (non-protein coding) 3.12603
MRNIP MRN complex interacting protein 3.11796
ELP4 elongator acetyltransferase complex subunit 4 3.1174
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.11701
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 3.11551
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.11184
UCN urocortin 3.11083
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 3.10783
TSPAN13 tetraspanin 13 3.10758
AMH anti-Mullerian hormone 3.10562
RNF141 ring finger protein 141 3.10394
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 3.10221
ZMAT4 zinc finger, matrin-type 4 3.10198
RASL10A RAS-like, family 10, member A 3.10191
TUBG2 tubulin, gamma 2 3.1011
ACYP1 acylphosphatase 1, erythrocyte (common) type 3.0941
HNRNPM heterogeneous nuclear ribonucleoprotein M 3.0831
GLO1 glyoxalase I 3.08001
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.07599
PROM1 prominin 1 3.07516
PLK1 polo-like kinase 1 3.07373
DTNB dystrobrevin, beta 3.0681
RPAIN RPA interacting protein 3.06768
FECH ferrochelatase 3.06699
C9ORF40 chromosome 9 open reading frame 40 3.06316
INTS14 integrator complex subunit 14 3.0612
SCGB2A2 secretoglobin, family 2A, member 2 3.05653
TMPRSS15 transmembrane protease, serine 15 3.05276
RHCE Rh blood group, CcEe antigens 3.05163
USP29 ubiquitin specific peptidase 29 3.0488
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 3.04866
KRT5 keratin 5, type II 3.04846
M6PR mannose-6-phosphate receptor (cation dependent) 3.04373
MEA1 male-enhanced antigen 1 3.03624
JADE3 jade family PHD finger 3 3.03385
RBBP8 retinoblastoma binding protein 8 3.03303
PIAS3 protein inhibitor of activated STAT, 3 3.02823
RND2 Rho family GTPase 2 3.0252
TMEM147-AS1 TMEM147 antisense RNA 1 3.02059
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 3.01837
STK16 serine/threonine kinase 16 3.01728
ACTA2 actin, alpha 2, smooth muscle, aorta 3.01337
GFRA1 GDNF family receptor alpha 1 3.00996
UMOD uromodulin 3.00945
CLSTN2 calsyntenin 2 3.00943
FUS FUS RNA binding protein 3.00632
SEPTIN10 septin 10 3.00225
ELAC1 elaC ribonuclease Z 1 3.00158
OSBPL3 oxysterol binding protein-like 3 3.00111
PCDH8 protocadherin 8 3.00042

decreased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 -10.4785
TUBB6 tubulin, beta 6 class V -6.84872
PFKL phosphofructokinase, liver -6.50723
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -6.05503
DLD dihydrolipoamide dehydrogenase -5.34551
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -5.33058
CCDC86 coiled-coil domain containing 86 -5.31034
CLEC1A C-type lectin domain family 1, member A -5.29392
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 -5.16042
LPAR3 lysophosphatidic acid receptor 3 -5.13486
CELF2 CUGBP, Elav-like family member 2 -5.09491
FGFR4 fibroblast growth factor receptor 4 -5.08909
SGF29 SAGA complex associated factor 29 -5.03454
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 -4.88337
ROGDI rogdi homolog (Drosophila) -4.82146
CDR2L cerebellar degeneration-related protein 2-like -4.78539
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.66089
ALG12 ALG12, alpha-1,6-mannosyltransferase -4.62491
TPT1 tumor protein, translationally-controlled 1 -4.59674
FAAH fatty acid amide hydrolase -4.57175
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -4.52955
CHN2 chimerin 2 -4.52347
RPL38 ribosomal protein L38 -4.50849
ECM2 extracellular matrix protein 2, female organ and adipocyte specific -4.49329
PLSCR3 phospholipid scramblase 3 -4.4505
GYPC glycophorin C (Gerbich blood group) -4.43861
GUCY2C guanylate cyclase 2C -4.40692
TBXA2R thromboxane A2 receptor -4.39537
MFAP5 microfibrillar associated protein 5 -4.35836
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 -4.35627
NUP85 nucleoporin 85kDa -4.32251
SVIL supervillin -4.3207
CLEC11A C-type lectin domain family 11, member A -4.30195
CD302 CD302 molecule -4.29427
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -4.24328
SUMO4 small ubiquitin-like modifier 4 -4.22548
UXS1 UDP-glucuronate decarboxylase 1 -4.20447
MYRF myelin regulatory factor -4.18237
HLA-F-AS1 HLA-F antisense RNA 1 -4.1318
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) -4.12977
CIAO1 cytosolic iron-sulfur assembly component 1 -4.12254
SCMH1 sex comb on midleg homolog 1 (Drosophila) -4.11963
SARS2 seryl-tRNA synthetase 2, mitochondrial -4.09421
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -4.08579
PRKCH protein kinase C, eta -4.08194
MAPKBP1 mitogen-activated protein kinase binding protein 1 -4.06433
SKI SKI proto-oncogene -4.0086
ZBTB10 zinc finger and BTB domain containing 10 -4.00207
TCL1B T-cell leukemia/lymphoma 1B -3.99959
TOGARAM1 TOG array regulator of axonemal microtubules 1 -3.98466
FXYD1 FXYD domain containing ion transport regulator 1 -3.97736
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -3.97724
PLSCR4 phospholipid scramblase 4 -3.97569
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.97385
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -3.9717
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 -3.95576
MSRB1 methionine sulfoxide reductase B1 -3.93377
GSTM5 glutathione S-transferase mu 5 -3.90681
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic -3.90371
ELANE elastase, neutrophil expressed -3.88274
TMEM94 transmembrane protein 94 -3.88008
CPQ carboxypeptidase Q -3.85419
GAS7 growth arrest-specific 7 -3.85287
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -3.82866
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -3.82622
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.80303
SLC2A4RG SLC2A4 regulator -3.77523
S1PR4 sphingosine-1-phosphate receptor 4 -3.76484
TGFBR3 transforming growth factor, beta receptor III -3.75941
PRTN3 proteinase 3 -3.75766
HMHB1 histocompatibility (minor) HB-1 -3.75399
FHIT fragile histidine triad -3.75214
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -3.74023
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -3.73637
CCN5 cellular communication network factor 5 -3.71749
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -3.71431
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -3.71363
CORO1B coronin, actin binding protein, 1B -3.6938
CIAO3 cytosolic iron-sulfur assembly component 3 -3.68318
SGSH N-sulfoglucosamine sulfohydrolase -3.68014
NAGLU N-acetylglucosaminidase, alpha -3.67611
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -3.65344
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -3.64206
CLUH clustered mitochondria (cluA/CLU1) homolog -3.63988
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.61548
SLC43A3 solute carrier family 43, member 3 -3.60866
LRP1 low density lipoprotein receptor-related protein 1 -3.60758
DPEP3 dipeptidase 3 -3.60536
DENND2A DENN/MADD domain containing 2A -3.60105
SBF1 SET binding factor 1 -3.58354
BNC2 basonuclin 2 -3.58352
CDX2 caudal type homeobox 2 -3.58152
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -3.57999
PVT1 Pvt1 oncogene (non-protein coding) -3.57488
RGS11 regulator of G-protein signaling 11 -3.57254
B3GAT3 beta-1,3-glucuronyltransferase 3 -3.56771
KLF3 Kruppel-like factor 3 (basic) -3.5657
KRT75 keratin 75, type II -3.565
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -3.56144
AMACR alpha-methylacyl-CoA racemase -3.55897
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -3.5552
SAP30BP SAP30 binding protein -3.5422
NUBP2 nucleotide binding protein 2 -3.54161
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -3.526
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial -3.51678
DENND3 DENN/MADD domain containing 3 -3.51637
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -3.50759
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -3.50565
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -3.49722
RPL19 ribosomal protein L19 -3.48167
VWA1 von Willebrand factor A domain containing 1 -3.47872
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -3.47841
GRM1 glutamate receptor, metabotropic 1 -3.47605
EVPL envoplakin -3.47413
CCNB1 cyclin B1 -3.47407
OSR2 odd-skipped related transciption factor 2 -3.46672
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -3.46566
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A -3.4563
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -3.44979
LRRC31 leucine rich repeat containing 31 -3.44122
DSC2 desmocollin 2 -3.4344
SLC22A17 solute carrier family 22, member 17 -3.43293
TMEM204 transmembrane protein 204 -3.42919
SEC61G Sec61 gamma subunit -3.42545
BPY2 basic charge, Y-linked, 2 -3.42489
GPRASP1 G protein-coupled receptor associated sorting protein 1 -3.41927
HIPK3 homeodomain interacting protein kinase 3 -3.41772
RELN reelin -3.39214
NDNF neuron-derived neurotrophic factor -3.3875
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -3.37372
B2M beta-2-microglobulin -3.37361
CORO7 coronin 7 -3.36639
PKD2 polycystic kidney disease 2 (autosomal dominant) -3.36251
CAPNS1 calpain, small subunit 1 -3.35787
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -3.35785
SEC23A Sec23 homolog A (S. cerevisiae) -3.35724
SKIC3 SKI3 subunit of superkiller complex -3.35358
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -3.3494
PRELID3A PRELI domain containing 3A -3.34386
MRPL16 mitochondrial ribosomal protein L16 -3.34214
CLCA2 chloride channel accessory 2 -3.34199
MYO3A myosin IIIA -3.33956
CCN6 cellular communication network factor 6 -3.3293
ORC5 origin recognition complex, subunit 5 -3.31955
TNPO1 transportin 1 -3.31828
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -3.31769
MAP7 microtubule-associated protein 7 -3.31625
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -3.30958
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -3.30564
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -3.30465
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -3.30064
LAMA2 laminin, alpha 2 -3.29895
ARSL arylsulfatase L -3.29091
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -3.28912
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -3.28741
SFRP4 secreted frizzled-related protein 4 -3.28056
SAMHD1 SAM domain and HD domain 1 -3.27451
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -3.27418
SEC14L5 SEC14-like 5 (S. cerevisiae) -3.27363
ARHGAP15 Rho GTPase activating protein 15 -3.27191
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -3.26852
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 -3.26642
TMC6 transmembrane channel-like 6 -3.25982
SRPK2 SRSF protein kinase 2 -3.2583
LRPPRC leucine-rich pentatricopeptide repeat containing -3.2565
CASP4 caspase 4, apoptosis-related cysteine peptidase -3.25459
CPPED1 calcineurin-like phosphoesterase domain containing 1 -3.25386
PDHX pyruvate dehydrogenase complex, component X -3.25299
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -3.25252
RCC1L RCC1 like -3.25249
TPP2 tripeptidyl peptidase II -3.25215
RASAL1 RAS protein activator like 1 (GAP1 like) -3.24603
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -3.23256
CEP57 centrosomal protein 57kDa -3.22603
SNHG32 small nucleolar RNA host gene 32 -3.22514
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -3.22446
LHFPL6 LHFPL tetraspan subfamily member 6 -3.22027
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.21399
COL4A5 collagen, type IV, alpha 5 -3.20865
SPOP speckle-type POZ protein -3.20636
CORO1A coronin, actin binding protein, 1A -3.2046
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) -3.20343
SSX7 synovial sarcoma, X breakpoint 7 -3.19417
FOXO1 forkhead box O1 -3.19081
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -3.1846
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -3.18308
ATXN8OS ATXN8 opposite strand (non-protein coding) -3.18212
C1QTNF1 C1q and tumor necrosis factor related protein 1 -3.182
QPRT quinolinate phosphoribosyltransferase -3.18118
HLA-A major histocompatibility complex, class I, A -3.1796
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -3.17712
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -3.17475
EBI3 Epstein-Barr virus induced 3 -3.16589
KCTD2 potassium channel tetramerization domain containing 2 -3.15515
ELP5 elongator acetyltransferase complex subunit 5 -3.1525
PNLIPRP2 pancreatic lipase-related protein 2 -3.1468
RPS29 ribosomal protein S29 -3.14292
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -3.13976
SCEL sciellin -3.13891
NEUROD1 neuronal differentiation 1 -3.13628
U2AF2 U2 small nuclear RNA auxiliary factor 2 -3.13527
RPS8 ribosomal protein S8 -3.13066
PDS5A PDS5 cohesin associated factor A -3.12921
ELOVL1 ELOVL fatty acid elongase 1 -3.1292
SPON2 spondin 2, extracellular matrix protein -3.12788
ANKRD12 ankyrin repeat domain 12 -3.12719
ZNF460 zinc finger protein 460 -3.12424
CASKIN2 CASK interacting protein 2 -3.12418
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -3.12405
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 -3.1239
PMM1 phosphomannomutase 1 -3.12246
PRPF4B pre-mRNA processing factor 4B -3.11341
PTCH2 patched 2 -3.1132
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -3.11243
ZFAND1 zinc finger, AN1-type domain 1 -3.11236
ZSCAN31 zinc finger and SCAN domain containing 31 -3.10704
C6 complement component 6 -3.10581
RFTN1 raftlin, lipid raft linker 1 -3.10418
AXIN1 axin 1 -3.10226
NRTN neurturin -3.09856
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -3.09458
DCAF6 DDB1 and CUL4 associated factor 6 -3.09408
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -3.08936
TMX2 thioredoxin-related transmembrane protein 2 -3.08574
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -3.07894
TP53TG1 TP53 target 1 (non-protein coding) -3.07849
TUBB4A tubulin, beta 4A class IVa -3.07024
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -3.06809
SREBF1 sterol regulatory element binding transcription factor 1 -3.06754
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -3.06593
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -3.06426
TBC1D10B TBC1 domain family, member 10B -3.06194
HOXD13 homeobox D13 -3.05838
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -3.05719
RYR2 ryanodine receptor 2 (cardiac) -3.05627
RAP1GAP2 RAP1 GTPase activating protein 2 -3.04688
USP36 ubiquitin specific peptidase 36 -3.04519
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -3.04442
RPL30 ribosomal protein L30 -3.03734
MRPL58 mitochondrial ribosomal protein L58 -3.03536
NOP14 NOP14 nucleolar protein -3.03164
CENPM centromere protein M -3.02685
AHCY adenosylhomocysteinase -3.02544
FADS3 fatty acid desaturase 3 -3.02239
GCM1 glial cells missing homolog 1 (Drosophila) -3.01865
TXNDC9 thioredoxin domain containing 9 -3.01792
DRG2 developmentally regulated GTP binding protein 2 -3.01647
IRF4 interferon regulatory factor 4 -3.01538
PRL prolactin -3.0125
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -3.01213