carcinoid Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182). Some carcinoid tumours are a phenotype associated with mutations in the SDHD Gene (evidence OMIM record http://www.omim.org/entry/602690) (Experimental Factor Ontology, EFO_0004243)
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Genes

50 genes co-occuring with the biological term carcinoid in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
BRAF B-Raf proto-oncogene, serine/threonine kinase
CA2 carbonic anhydrase II
CARTPT CART prepropeptide
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDX2 caudal type homeobox 2
CHGA chromogranin A
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLDN3 claudin 3
CLDN4 claudin 4
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCR4 chemokine (C-X-C motif) receptor 4
DAD1 defender against cell death 1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INHBA inhibin, beta A
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MEN1 multiple endocrine neoplasia I
MIR155 microRNA 155
MIR21 microRNA 21
MKI67 marker of proliferation Ki-67
NEUROD1 neuronal differentiation 1
NF1 neurofibromin 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
OTP orthopedia homeobox
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PRKD2 protein kinase D2
PTK2 protein tyrosine kinase 2
PXN paxillin
PYY peptide YY
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RET ret proto-oncogene
SCTR secretin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1