cartilage Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A specialized, fibrous connective tissue, forming most of the temporary skeleton of the embryo, providing a model in which most of the bones develop, and constituting an important part of the growth mechanism of the organism. It exists in several types, the most important of which are hyaline cartilage, elastic cartilage, and fibrocartilage. Also used as a general term to designate a mass of such tissue in a particular site in the body. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000206)
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Genes

292 genes co-occuring with the biological term cartilage in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACAN aggrecan
ACVRL1 activin A receptor type II-like 1
ADAM12 ADAM metallopeptidase domain 12
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALPL alkaline phosphatase, liver/bone/kidney
ANGPT1 angiopoietin 1
ANGPTL4 angiopoietin-like 4
ANKH ANKH inorganic pyrophosphate transport regulator
APOA1 apolipoprotein A-I
AR androgen receptor
ASPN asporin
ATF6 activating transcription factor 6
B3GAT3 beta-1,3-glucuronyltransferase 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BARX1 BARX homeobox 1
BCL2 B-cell CLL/lymphoma 2
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BGLAP bone gamma-carboxyglutamate (gla) protein
BGN biglycan
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMPR1A bone morphogenetic protein receptor, type IA
BSG basigin (Ok blood group)
C3 complement component 3
CABIN1 calcineurin binding protein 1
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL11 chemokine (C-C motif) ligand 11
CCND1 cyclin D1
CD151 CD151 molecule (Raph blood group)
CD163 CD163 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHAD chondroadherin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHRD chordin
CHRDL2 chordin-like 2
CILP2 cartilage intermediate layer protein 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
COL10A1 collagen, type X, alpha 1
COL11A2 collagen, type XI, alpha 2
COL16A1 collagen, type XVI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL6A3 collagen, type VI, alpha 3
COL6A4P1 collagen, type VI, alpha 4 pseudogene 1
COL7A1 collagen, type VII, alpha 1
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CRLF1 cytokine receptor-like factor 1
CRP C-reactive protein, pentraxin-related
CRTAC1 cartilage acidic protein 1
CSF1 colony stimulating factor 1 (macrophage)
CTGF connective tissue growth factor
CTNNBIP1 catenin, beta interacting protein 1
CTSK cathepsin K
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
DCC DCC netrin 1 receptor
DCN decorin
DCX doublecortin
DDR2 discoidin domain receptor tyrosine kinase 2
DEFB103B defensin, beta 103B
DEFB4A defensin, beta 4A
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMP1 dentin matrix acidic phosphoprotein 1
DOT1L DOT1-like histone H3K79 methyltransferase
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EGLN1 egl-9 family hypoxia-inducible factor 1
ELANE elastase, neutrophil expressed
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENGASE endo-beta-N-acetylglucosaminidase
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
ESRRA estrogen-related receptor alpha
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FADD Fas (TNFRSF6)-associated via death domain
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FGF18 fibroblast growth factor 18
FGF2 fibroblast growth factor 2 (basic)
FGFR3 fibroblast growth factor receptor 3
FMOD fibromodulin
FN1 fibronectin 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
GADD45B growth arrest and DNA-damage-inducible, beta
GALE UDP-galactose-4-epimerase
GALNS galactosamine (N-acetyl)-6-sulfatase
GDF5 growth differentiation factor 5
GHRL ghrelin/obestatin prepropeptide
GREM1 gremlin 1, DAN family BMP antagonist
GUSB glucuronidase, beta
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC1 histone deacetylase 1
HDAC7 histone deacetylase 7
HES5 hes family bHLH transcription factor 5
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHIP hedgehog interacting protein
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HOTTIP HOXA distal transcript antisense RNA
HRH1 histamine receptor H1
HRH2 histamine receptor H2
HSPG2 heparan sulfate proteoglycan 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IHH indian hedgehog
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL21R interleukin 21 receptor
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KERA keratocan
KL klotho
KLF5 Kruppel-like factor 5 (intestinal)
KLK14 kallikrein-related peptidase 14
LAYN layilin
LCN2 lipocalin 2
LECT1 leukocyte cell derived chemotaxin 1
LEP leptin
LEPR leptin receptor
LRP1 low density lipoprotein receptor-related protein 1
LRP5 low density lipoprotein receptor-related protein 5
LTF lactotransferrin
LUM lumican
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MATN1 matrilin 1, cartilage matrix protein
MATN3 matrilin 3
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MIA melanoma inhibitory activity
MIR1-1 microRNA 1-1
MIR140 microRNA 140
MIR146A microRNA 146a
MIR148A microRNA 148a
MIR181B1 microRNA 181b-1
MIR18A microRNA 18a
MIR223 microRNA 223
MIR558 microRNA 558
MIR675 microRNA 675
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
NAMPT nicotinamide phosphoribosyltransferase
NELL1 NEL-like 1 (chicken)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NOG noggin
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OSM oncostatin M
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE procollagen C-endopeptidase enhancer
PCSK6 proprotein convertase subtilisin/kexin type 6
PDPN podoplanin
PITX1 paired-like homeodomain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRELP proline/arginine-rich end leucine-rich repeat protein
PRG4 proteoglycan 4
PRKCZ protein kinase C, zeta
PRL prolactin
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RCOR1 REST corepressor 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RMRP RNA component of mitochondrial RNA processing endoribonuclease
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RUNX2 runt-related transcription factor 2
RXFP1 relaxin/insulin-like family peptide receptor 1
S100A1 S100 calcium binding protein A1
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SAA1 serum amyloid A1
SDC1 syndecan 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SETDB1 SET domain, bifurcated 1
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOST sclerostin
SOX5 SRY (sex determining region Y)-box 5
SOX6 SRY (sex determining region Y)-box 6
SOX9 SRY (sex determining region Y)-box 9
SP1 Sp1 transcription factor
SP7 Sp7 transcription factor
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULF1 sulfatase 1
SULF2 sulfatase 2
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEK TEK tyrosine kinase, endothelial
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR3 transforming growth factor, beta receptor III
TGM2 transglutaminase 2
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIMP2 TIMP metallopeptidase inhibitor 2
TIMP4 TIMP metallopeptidase inhibitor 4
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNC tenascin C
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TRIB3 tribbles pseudokinase 3
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TTN titin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VWA1 von Willebrand factor A domain containing 1
WIF1 WNT inhibitory factor 1
WISP1 WNT1 inducible signaling pathway protein 1
WISP3 WNT1 inducible signaling pathway protein 3
WNT7A wingless-type MMTV integration site family, member 7A