casp8 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description caspase 8, apoptosis-related cysteine peptidase|This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 841)
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Genes

32 genes co-occuring with the biological term casp8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
BAX BCL2-associated X protein
BCAP31 B-cell receptor-associated protein 31
BID BH3 interacting domain death agonist
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CARD8 caspase recruitment domain family, member 8
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CFLAR CASP8 and FADD-like apoptosis regulator
COX6C cytochrome c oxidase subunit VIc
COX7B cytochrome c oxidase subunit VIIb
FASLG Fas ligand (TNF superfamily, member 6)
GATA6 GATA binding protein 6
IFNG interferon, gamma
IL21 interleukin 21
MGMT O-6-methylguanine-DNA methyltransferase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
SCGB3A1 secretoglobin, family 3A, member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZNF154 zinc finger protein 154