cat Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description catalase|This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 847)
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Genes

40 genes co-occuring with the biological term cat in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AR androgen receptor
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BAX BCL2-associated X protein
CAT catalase
CD40LG CD40 ligand
CECR2 cat eye syndrome chromosome region, candidate 2
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTSD cathepsin D
CTSK cathepsin K
CTSL cathepsin L
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
F8 coagulation factor VIII, procoagulant component
FLG filaggrin
GPX1 glutathione peroxidase 1
GSR glutathione reductase
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HMOX1 heme oxygenase 1
HP haptoglobin
IL10 interleukin 10
MPO myeloperoxidase
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
PARP1 poly (ADP-ribose) polymerase 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R10 protein phosphatase 1, regulatory subunit 10
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SFTPA1 surfactant protein A1
SLC25A18 solute carrier family 25 (glutamate carrier), member 18
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
TP53 tumor protein p53
VWF von Willebrand factor