cav1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description caveolin 1, caveolae protein, 22kDa|The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 857)
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Genes

96 genes co-occuring with the biological term cav1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACVRL1 activin A receptor type II-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOA1 apolipoprotein A-I
AQP5 aquaporin 5
ATG12 autophagy related 12
ATG5 autophagy related 5
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BAD BCL2-associated agonist of cell death
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLTA clathrin, light chain A
COL1A2 collagen, type I, alpha 2
DERL1 derlin 1
DLC1 DLC1 Rho GTPase activating protein
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASN fatty acid synthase
FOXM1 forkhead box M1
FOXO3 forkhead box O3
GATA6 GATA binding protein 6
GLI1 GLI family zinc finger 1
HEPACAM hepatic and glial cell adhesion molecule
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDR kinase insert domain receptor
KLK1 kallikrein 1
LGALS3 lectin, galactoside-binding, soluble, 3
LRP6 low density lipoprotein receptor-related protein 6
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PGR progesterone receptor
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PRKCA protein kinase C, alpha
PRKCDBP protein kinase C, delta binding protein
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTRF polymerase I and transcript release factor
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS14 regulator of G-protein signaling 14
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SLC16A4 solute carrier family 16, member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD1 SMAD family member 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
STIM1 stromal interaction molecule 1
TES testin LIM domain protein
THEM4 thioesterase superfamily member 4
TP53 tumor protein p53
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UBXN6 UBX domain protein 6
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
WNT6 wingless-type MMTV integration site family, member 6