cbl Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Cbl proto-oncogene, E3 ubiquitin protein ligase|This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 867)
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Genes

67 genes co-occuring with the biological term cbl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AREG amphiregulin
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ASXL1 additional sex combs like transcriptional regulator 1
BCR breakpoint cluster region
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL12 chemokine (C-X-C motif) ligand 12
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
EPHB1 EPH receptor B1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERRFI1 ERBB receptor feedback inhibitor 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR2 fibroblast growth factor receptor 2
FLT3 fms-related tyrosine kinase 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GRB2 growth factor receptor-bound protein 2
GSTA1 glutathione S-transferase alpha 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IGF1 insulin-like growth factor 1 (somatomedin C)
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF8 interferon regulatory factor 8
ITSN1 intersectin 1 (SH3 domain protein)
JAK2 Janus kinase 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2A lysine (K)-specific methyltransferase 2A
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MIR188 microRNA 188
MIR98 microRNA 98
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
OSTF1 osteoclast stimulating factor 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDCD6IP programmed cell death 6 interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTK2 protein tyrosine kinase 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
SH3KBP1 SH3-domain kinase binding protein 1
SORBS2 sorbin and SH3 domain containing 2
SOS1 son of sevenless homolog 1 (Drosophila)
SPN sialophorin
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
SYK spleen tyrosine kinase
TCN2 transcobalamin II
TET2 tet methylcytosine dioxygenase 2
TNK2 tyrosine kinase, non-receptor, 2
UBASH3A ubiquitin associated and SH3 domain containing A
UBASH3B ubiquitin associated and SH3 domain containing B
VAV1 vav 1 guanine nucleotide exchange factor