ccl5 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description chemokine (C-C motif) ligand 5|This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 6352)
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Genes

71 genes co-occuring with the biological term ccl5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
CAMP cathelicidin antimicrobial peptide
CCL11 chemokine (C-C motif) ligand 11
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL26 chemokine (C-C motif) ligand 26
CCL3 chemokine (C-C motif) ligand 3
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GLI2 GLI family zinc finger 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL13 interleukin 13
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL4R interleukin 4 receptor
IL6 interleukin 6
IRF1 interferon regulatory factor 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
JAK2 Janus kinase 2
JUN jun proto-oncogene
KLF13 Kruppel-like factor 13
MAPK14 mitogen-activated protein kinase 14
MIR302A microRNA 302a
MMP9 matrix metallopeptidase 9
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1H3 nuclear receptor subfamily 1, group H, member 3
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PTPRE protein tyrosine phosphatase, receptor type, E
RAD50 RAD50 homolog (S. cerevisiae)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOD1 superoxide dismutase 1, soluble
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBXA2R thromboxane A2 receptor
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR3 toll-like receptor 3
TNF tumor necrosis factor
VIP vasoactive intestinal peptide
VIPR2 vasoactive intestinal peptide receptor 2
YBX1 Y box binding protein 1