ccnd1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cyclin D1|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 595)
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Genes

79 genes co-occuring with the biological term ccnd1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
C11ORF30 chromosome 11 open reading frame 30
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DDHD2 DDHD domain containing 2
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
HEXIM1 hexamethylene bis-acetamide inducible 1
IGF2 insulin-like growth factor 2
KDM4B lysine (K)-specific demethylase 4B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRT7 keratin 7, type II
LIN28A lin-28 homolog A (C. elegans)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIR138-1 microRNA 138-1
MIR155 microRNA 155
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR193B microRNA 193b
MIR19A microRNA 19a
MIR33A microRNA 33a
MIR34A microRNA 34a
MIR383 microRNA 383
MIR449B microRNA 449b
MIR490 microRNA 490
MIR503 microRNA 503
MKI67 marker of proliferation Ki-67
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIPBL Nipped-B homolog (Drosophila)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUCLEOLIN nucleolin multifunctional protein
PGR progesterone receptor
POU5F1 POU class 5 homeobox 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRMT2 protein arginine methyltransferase 2
PTEN phosphatase and tensin homolog
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RHOBTB2 Rho-related BTB domain containing 2
SDC4 syndecan 4
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SSB Sjogren syndrome antigen B (autoantigen La)
TERT telomerase reverse transcriptase
TP53 tumor protein p53
VEGFA vascular endothelial growth factor A
VRK1 vaccinia related kinase 1
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZNF703 zinc finger protein 703