ccr5 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description chemokine (C-C motif) receptor 5 (gene/pseudogene)|This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1234)
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Genes

89 genes co-occuring with the biological term ccr5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
AFP alpha-fetoprotein
AGER advanced glycosylation end product-specific receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APP amyloid beta (A4) precursor protein
BTG1 B-cell translocation gene 1, anti-proliferative
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD274 CD274 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD81 CD81 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLEC4M C-type lectin domain family 4, member M
CLK1 CDC-like kinase 1
CREB1 cAMP responsive element binding protein 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXCR6 chemokine (C-X-C motif) receptor 6
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
GPR1 G protein-coupled receptor 1
GPR15 G protein-coupled receptor 15
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCP5 HLA complex P5 (non-protein coding)
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IL10 interleukin 10
IL13 interleukin 13
IL15 interleukin 15
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL4 interleukin 4
IL7 interleukin 7
KLF2 Kruppel-like factor 2
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
MAPK14 mitogen-activated protein kinase 14
NUP85 nucleoporin 85kDa
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU2F1 POU class 2 homeobox 1
POU2F2 POU class 2 homeobox 2
PRKCZ protein kinase C, zeta
PTPRC protein tyrosine phosphatase, receptor type, C
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD1 superoxide dismutase 1, soluble
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TPST1 tyrosylprotein sulfotransferase 1
TPST2 tyrosylprotein sulfotransferase 2
YY1 YY1 transcription factor