ccr7 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description chemokine (C-C motif) receptor 7|The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 1236)
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Genes

56 genes co-occuring with the biological term ccr7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACKR4 atypical chemokine receptor 4
ADORA2A adenosine A2a receptor
ALK anaplastic lymphoma receptor tyrosine kinase
ARR3 arrestin 3, retinal (X-arrestin)
ARRB2 arrestin, beta 2
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCR10 chemokine (C-C motif) receptor 10
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD244 CD244 molecule, natural killer cell receptor 2B4
CD27 CD27 molecule
CD38 CD38 molecule
CD68 CD68 molecule
CMKLR1 chemerin chemokine-like receptor 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
DEFB103A defensin, beta 103A
DEFB103B defensin, beta 103B
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLT4 fms-related tyrosine kinase 4
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDR kinase insert domain receptor
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MIR21 microRNA 21
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C2 nuclear receptor subfamily 3, group C, member 2
PEG10 paternally expressed 10
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PRF1 perforin 1 (pore forming protein)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPRC protein tyrosine phosphatase, receptor type, C
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
S1PR1 sphingosine-1-phosphate receptor 1
SELL selectin L
SP1 Sp1 transcription factor
SSTR5 somatostatin receptor 5
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
VEGFC vascular endothelial growth factor C