cd40 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description CD40 molecule, TNF receptor superfamily member 5|This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 958)
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Genes

120 genes co-occuring with the biological term cd40 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX5 arachidonate 5-lipoxygenase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BIRC2 baculoviral IAP repeat containing 2
BTK Bruton agammaglobulinemia tyrosine kinase
C4BPA complement component 4 binding protein, alpha
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD27 CD27 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD80 CD80 molecule
CD83 CD83 molecule
CD86 CD86 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CRP C-reactive protein, pentraxin-related
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSS cathepsin S
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
FAIM Fas apoptotic inhibitory molecule
FAS Fas cell surface death receptor
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCRL3 Fc receptor-like 3
GADD45B growth arrest and DNA-damage-inducible, beta
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGB1 high mobility group box 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL17A interleukin 17A
IL17F interleukin 17F
IL1B interleukin 1, beta
IL20 interleukin 20
IL21 interleukin 21
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL4 interleukin 4
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
IRF1 interferon regulatory factor 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK3 Janus kinase 3
KDM6B lysine (K)-specific demethylase 6B
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MIR503 microRNA 503
MMP9 matrix metallopeptidase 9
NCOR2 nuclear receptor corepressor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAUR plasminogen activator, urokinase receptor
PLG plasminogen
PPARG peroxisome proliferator-activated receptor gamma
PRKCZ protein kinase C, zeta
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIRT1 sirtuin 1
SLAMF1 signaling lymphocytic activation molecule family member 1
TANK TRAF family member-associated NFKB activator
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSLP thymic stromal lymphopoietin
USP48 ubiquitin specific peptidase 48
UTS2 urotensin 2
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor