cd44 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description CD44 molecule (Indian blood group)|The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 960)
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Genes

213 genes co-occuring with the biological term cd44 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AR androgen receptor
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
BCAP31 B-cell receptor-associated protein 31
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCR breakpoint cluster region
BMI1 BMI1 proto-oncogene, polycomb ring finger
BSG basigin (Ok blood group)
CA9 carbonic anhydrase IX
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX3 chromobox homolog 3
CD151 CD151 molecule (Raph blood group)
CD24 CD24 molecule
CD27 CD27 molecule
CD38 CD38 molecule
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD70 CD70 molecule
CD81 CD81 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CLEC4G C-type lectin domain family 4, member G
COL4A1 collagen, type IV, alpha 1
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMP1 dentin matrix acidic phosphoprotein 1
DNM2 dynamin 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
EZR ezrin
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FKBPL FK506 binding protein like
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GLG1 golgi glycoprotein 1
GMNN geminin, DNA replication inhibitor
HAS1 hyaluronan synthase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPX hemopexin
HYAL1 hyaluronoglucosaminidase 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGH immunoglobulin heavy locus
IL18 interleukin 18
IL1B interleukin 1, beta
IL24 interleukin 24
IL4 interleukin 4
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JUN jun proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT20 keratin 20, type I
KRT5 keratin 5, type II
L1CAM L1 cell adhesion molecule
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR106B microRNA 106b
MIR139 microRNA 139
MIR199A1 microRNA 199a-1
MIR199A2 microRNA 199a-2
MIR21 microRNA 21
MIR328 microRNA 328
MIR34A microRNA 34a
MIR7-1 microRNA 7-1
MIR708 microRNA 708
MKI67 marker of proliferation Ki-67
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MSI1 musashi RNA-binding protein 1
MSN moesin
MSR1 macrophage scavenger receptor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NES nestin
NF2 neurofibromin 2 (merlin)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
OTP orthopedia homeobox
PCBP1 poly(rC) binding protein 1
PCNA proliferating cell nuclear antigen
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDHX pyruvate dehydrogenase complex, component X
PDPN podoplanin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCE1 phospholipase C, epsilon 1
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PROM1 prominin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PVR poliovirus receptor
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RDX radixin
RET ret proto-oncogene
RUNX2 runt-related transcription factor 2
SDC1 syndecan 1
SDC4 syndecan 4
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SIX1 SIX homeobox 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A4 solute carrier family 16, member 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNAI2 snail family zinc finger 2
SPHK1 sphingosine kinase 1
SPN sialophorin
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM1 serine/arginine repetitive matrix 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF6 serine/arginine-rich splicing factor 6
STAB2 stabilin 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFCP2 transcription factor CP2
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGM2 transglutaminase 2
THAP11 THAP domain containing 11
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNC tenascin C
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TWIST1 twist family bHLH transcription factor 1
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
VPRBP Vpr (HIV-1) binding protein
WNT5A wingless-type MMTV integration site family, member 5A
YBX1 Y box binding protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta