cd74 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description CD74 molecule, major histocompatibility complex, class II invariant chain|The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 972)
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Genes

29 genes co-occuring with the biological term cd74 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AGTR1 angiotensin II receptor, type 1
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD38 CD38 molecule
CD47 CD47 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
EBAG9 estrogen receptor binding site associated, antigen, 9
EGFR epidermal growth factor receptor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNGR1 interferon gamma receptor 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PTPRC protein tyrosine phosphatase, receptor type, C
SPPL2A signal peptide peptidase like 2A
STAT1 signal transducer and activator of transcription 1, 91kDa
TLR2 toll-like receptor 2
TP63 tumor protein p63
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa