cdc25a Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cell division cycle 25A|CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 993)
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Genes

67 genes co-occuring with the biological term cdc25a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
AR androgen receptor
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BOLL boule-like RNA-binding protein
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CBX1 chromobox homolog 1
CCNB1 cyclin B1
CCND1 cyclin D1
CCND3 cyclin D3
CCNE1 cyclin E1
CDC14A cell division cycle 14A
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK6 cyclin-dependent kinase 6
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CSNK1A1 casein kinase 1, alpha 1
CSNK1E casein kinase 1, epsilon
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FASN fatty acid synthase
FOXM1 forkhead box M1
FOXO1 forkhead box O1
GSK3B glycogen synthase kinase 3 beta
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
JAK2 Janus kinase 2
LIN28A lin-28 homolog A (C. elegans)
MAPK14 mitogen-activated protein kinase 14
MIR34C microRNA 34c
MIR424 microRNA 424
MIR449B microRNA 449b
MIR503 microRNA 503
MIRLET7C microRNA let-7c
MMP1 matrix metallopeptidase 1
NEK11 NIMA-related kinase 11
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SH3GL2 SH3-domain GRB2-like 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SP1 Sp1 transcription factor
TP53 tumor protein p53
TP73 tumor protein p73
USP17L2 ubiquitin specific peptidase 17-like family member 2
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa