cdc42 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cell division cycle 42|The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] (NCBI Entrez Gene Database, 998)
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Genes

104 proteins co-occuring with the biological term cdc42 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AQP2 aquaporin 2 (collecting duct)
AQP9 aquaporin 9
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP31 Rho GTPase activating protein 31
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC42 cell division cycle 42
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CFL1 cofilin 1 (non-muscle)
CREB1 cAMP responsive element binding protein 1
CSF1R colony stimulating factor 1 receptor
DCD dermcidin
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DOCK6 dedicator of cytokinesis 6
DOCK7 dedicator of cytokinesis 7
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
ERBB2 erb-b2 receptor tyrosine kinase 2
EZR ezrin
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGD1 FYVE, RhoGEF and PH domain containing 1
FHOD1 formin homology 2 domain containing 1
FLT3 fms-related tyrosine kinase 3
FMR1 fragile X mental retardation 1
FXR1 fragile X mental retardation, autosomal homolog 1
GMFG glia maturation factor, gamma
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPSM2 G-protein signaling modulator 2
GSK3B glycogen synthase kinase 3 beta
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
KDR kinase insert domain receptor
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSN moesin
MYL12B myosin, light chain 12B, regulatory
MYL9 myosin, light chain 9, regulatory
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDEL1 nudE neurodevelopment protein 1-like 1
NF2 neurofibromin 2 (merlin)
NGEF neuronal guanine nucleotide exchange factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARD3 par-3 family cell polarity regulator
PGAM1 phosphoglycerate mutase 1 (brain)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCG1 phospholipase C, gamma 1
PLK1 polo-like kinase 1
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKD3 protein kinase D3
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RDX radixin
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX2 runt-related transcription factor 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STMN1 stathmin 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TNK2 tyrosine kinase, non-receptor, 2
TRIO trio Rho guanine nucleotide exchange factor
TRIP10 thyroid hormone receptor interactor 10
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VIM vimentin
WAS Wiskott-Aldrich syndrome
WASL Wiskott-Aldrich syndrome-like
WIPF1 WAS/WASL interacting protein family, member 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa