cdh1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cadherin 1, type 1, E-cadherin (epithelial)|This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 999)
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Genes

84 genes co-occuring with the biological term cdh1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APC adenomatous polyposis coli
ARHGAP35 Rho GTPase activating protein 35
AURKA aurora kinase A
AURKB aurora kinase B
AXIN2 axin 2
BCL2 B-cell CLL/lymphoma 2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDH16 cadherin 16, KSP-cadherin
CDK2 cyclin-dependent kinase 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CGN cingulin
CHEK1 checkpoint kinase 1
CKAP2 cytoskeleton associated protein 2
CLDN4 claudin 4
CLSPN claspin
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CUL1 cullin 1
DAPK1 death-associated protein kinase 1
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EIF4A3 eukaryotic translation initiation factor 4A3
FBXO5 F-box protein 5
FHOD1 formin homology 2 domain containing 1
FOXM1 forkhead box M1
FZD9 frizzled class receptor 9
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GLI2 GLI family zinc finger 2
GSN gelsolin
HRH2 histamine receptor H2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
IL6 interleukin 6
ILK integrin-linked kinase
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KDM1A lysine (K)-specific demethylase 1A
KLK10 kallikrein-related peptidase 10
LOXL2 lysyl oxidase-like 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MGMT O-6-methylguanine-DNA methyltransferase
MIR100 microRNA 100
MIR214 microRNA 214
MIR25 microRNA 25
MIR373 microRNA 373
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
SALL1 spalt-like transcription factor 1
SALL4 spalt-like transcription factor 4
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNAI1 snail family zinc finger 1
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TLR9 toll-like receptor 9
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP37 ubiquitin specific peptidase 37
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNT2 wingless-type MMTV integration site family member 2
YBX1 Y box binding protein 1
ZEB1 zinc finger E-box binding homeobox 1