cdk/crk-inhibitor Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

55 genes differentially expressed following the cdk/crk-inhibitor small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
EGR1 early growth response 1 7.70888
NTS neurotensin 4.05818
BTG2 BTG family, member 2 3.7339
LAMP3 lysosomal-associated membrane protein 3 3.55254
CD68 CD68 molecule 3.3139
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 3.26227
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 3.24786
HEXA hexosaminidase A (alpha polypeptide) 3.22259
PRSS21 protease, serine, 21 (testisin) 3.19401
TBX2 T-box 2 3.16673
MSH3 mutS homolog 3 3.11939
GADD45B growth arrest and DNA-damage-inducible, beta 3.08988
PROP1 PROP paired-like homeobox 1 3.07404
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 3.06907
FGF23 fibroblast growth factor 23 3.05668
HIGD1B HIG1 hypoxia inducible domain family, member 1B 3.05112
HFE hemochromatosis 3.04905
FOS FBJ murine osteosarcoma viral oncogene homolog 3.04644
ADAM9 ADAM metallopeptidase domain 9 3.04198
NR4A1 nuclear receptor subfamily 4, group A, member 1 3.03896

decreased expression

Symbol Name Standardized Value
TTC4 tetratricopeptide repeat domain 4 -4.43488
CHERP calcium homeostasis endoplasmic reticulum protein -4.17297
CANT1 calcium activated nucleotidase 1 -4.02546
NGDN neuroguidin, EIF4E binding protein -3.87022
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -3.83136
AKAP8 A kinase (PRKA) anchor protein 8 -3.71165
WDR82 WD repeat domain 82 -3.69376
DUSP7 dual specificity phosphatase 7 -3.64097
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -3.59545
TMEM11 transmembrane protein 11 -3.57368
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -3.50868
SERTAD2 SERTA domain containing 2 -3.49663
LIPG lipase, endothelial -3.47366
RNMT RNA (guanine-7-) methyltransferase -3.42155
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -3.41418
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -3.40124
SEC24B SEC24 family member B -3.37192
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -3.33125
METTL13 methyltransferase like 13 -3.27837
AMD1 adenosylmethionine decarboxylase 1 -3.27795
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.26055
SLC25A44 solute carrier family 25, member 44 -3.22356
TBP TATA box binding protein -3.17811
GEMIN4 gem (nuclear organelle) associated protein 4 -3.17389
RAE1 ribonucleic acid export 1 -3.14032
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -3.12632
TSPYL4 TSPY-like 4 -3.11316
MDRV muscular dystrophy, with rimmed vacuoles -3.1123
SPATA2 spermatogenesis associated 2 -3.10395
HOXA10 homeobox A10 -3.09982
WDR59 WD repeat domain 59 -3.08932
MTHFSD methenyltetrahydrofolate synthetase domain containing -3.08458
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -3.01256
YTHDC1 YTH domain containing 1 -3.00783
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -3.00374