cdk1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cyclin-dependent kinase 1|The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 983)
Similar Terms
Downloads & Tools

Genes

99 genes co-occuring with the biological term cdk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKAP8L A kinase (PRKA) anchor protein 8-like
APC adenomatous polyposis coli
AURKA aurora kinase A
AURKB aurora kinase B
BCL2 B-cell CLL/lymphoma 2
BMP4 bone morphogenetic protein 4
BRCA1 breast cancer 1, early onset
BTG2 BTG family, member 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL21 chemokine (C-C motif) ligand 21
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND3 cyclin D3
CCR7 chemokine (C-C motif) receptor 7
CDC14A cell division cycle 14A
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC6 cell division cycle 6
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP152 centrosomal protein 152kDa
CEP63 centrosomal protein 63kDa
CHEK1 checkpoint kinase 1
CLASP2 cytoplasmic linker associated protein 2
CUEDC2 CUE domain containing 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELAVL1 ELAV like RNA binding protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO5 F-box protein 5
FCP1 F-cell production 1
FLNA filamin A, alpha
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS2L3 growth arrest-specific 2 like 3
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IL24 interleukin 24
INCENP inner centromere protein antigens 135/155kDa
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIN9 lin-9 DREAM MuvB core complex component
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MDC1 mediator of DNA-damage checkpoint 1
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NDC80 NDC80 kinetochore complex component
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NUMA1 nuclear mitotic apparatus protein 1
NUSAP1 nucleolar and spindle associated protein 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLK1 polo-like kinase 1
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP4C protein phosphatase 4, catalytic subunit
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RALBP1 ralA binding protein 1
RARG retinoic acid receptor, gamma
RHOA ras homolog family member A
RPN2 ribophorin II
RPS3 ribosomal protein S3
SEPT9 septin 9
SP1 Sp1 transcription factor
STIL SCL/TAL1 interrupting locus
TMPO thymopoietin
TP53 tumor protein p53
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WEE1 WEE1 G2 checkpoint kinase
WWC1 WW and C2 domain containing 1