cdk4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cyclin-dependent kinase 4|The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1019)
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Genes

79 genes co-occuring with the biological term cdk4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AHR aryl hydrocarbon receptor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTG2 BTG family, member 2
CBX7 chromobox homolog 7
CCNA1 cyclin A1
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CDC37 cell division cycle 37
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDT1 chromatin licensing and DNA replication factor 1
CDX2 caudal type homeobox 2
CLCN3 chloride channel, voltage-sensitive 3
DSC1 desmocollin 1
DSC2 desmocollin 2
DSC3 desmocollin 3
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
EGFR epidermal growth factor receptor
EIF3A eukaryotic translation initiation factor 3, subunit A
ERVW-1 endogenous retrovirus group W, member 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXM1 forkhead box M1
FOXO1 forkhead box O1
GLI1 GLI family zinc finger 1
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
KRAS Kirsten rat sarcoma viral oncogene homolog
MAPK8 mitogen-activated protein kinase 8
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR195 microRNA 195
MIR206 microRNA 206
MIR34A microRNA 34a
MIR506 microRNA 506
MIR545 microRNA 545
MIRLET7C microRNA let-7c
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEK2 NIMA-related kinase 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAX3 paired box 3
PITX1 paired-like homeodomain 1
POU4F2 POU class 4 homeobox 2
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTK2 protein tyrosine kinase 2
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPN2 ribophorin II
SERTAD1 SERTA domain containing 1
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD2 SMAD family member 2
SOX9 SRY (sex determining region Y)-box 9
SSTR2 somatostatin receptor 2
STK38 serine/threonine kinase 38
STK38L serine/threonine kinase 38 like
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TSPAN31 tetraspanin 31
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)