cdk5 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cyclin-dependent kinase 5|This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] (NCBI Entrez Gene Database, 1020)
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Genes

57 genes co-occuring with the biological term cdk5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARHGAP5 Rho GTPase activating protein 5
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPH aspartate beta-hydroxylase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATXN2 ataxin 2
BACE1 beta-site APP-cleaving enzyme 1
CABLES1 Cdk5 and Abl enzyme substrate 1
CCNB1 cyclin B1
CCND1 cyclin D1
CCNG1 cyclin G1
CDCA5 cell division cycle associated 5
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CSNK1A1 casein kinase 1, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
DLC1 DLC1 Rho GTPase activating protein
DPYSL2 dihydropyrimidinase-like 2
DRD3 dopamine receptor D3
ELAVL1 ELAV like RNA binding protein 1
GPHN gephyrin
HRAS Harvey rat sarcoma viral oncogene homolog
HSPB1 heat shock 27kDa protein 1
HTRA2 HtrA serine peptidase 2
HTT huntingtin
LMTK1 lemur tail kinase 1
MAPT microtubule-associated protein tau
MIR107 microRNA 107
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C2 nuclear receptor subfamily 3, group C, member 2
ODF2 outer dense fiber of sperm tails 2
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
PARK2 parkin RBR E3 ubiquitin protein ligase
PLD2 phospholipase D2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
RB1 retinoblastoma 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TP53 tumor protein p53
TTBK1 tau tubulin kinase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin