cdk9 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cyclin-dependent kinase 9|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1025)
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Genes

45 genes co-occuring with the biological term cdk9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AR androgen receptor
BMP2 bone morphogenetic protein 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRD4 bromodomain containing 4
CCL2 chemokine (C-C motif) ligand 2
CCNK cyclin K
CCNT1 cyclin T1
CCNT2 cyclin T2
CDC20 cell division cycle 20
CDC7 cell division cycle 7
CDK2 cyclin-dependent kinase 2
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLK3 CDC-like kinase 3
ELL elongation factor RNA polymerase II
EP300 E1A binding protein p300
FGG fibrinogen gamma chain
GATA4 GATA binding protein 4
HEXIM1 hexamethylene bis-acetamide inducible 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL6 interleukin 6
IRF3 interferon regulatory factor 3
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KMT2A lysine (K)-specific methyltransferase 2A
MCL1 myeloid cell leukemia 1
MIR874 microRNA 874
MMP9 matrix metallopeptidase 9
NPAT nuclear protein, ataxia-telangiectasia locus
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
RN7SK RNA, 7SK small nuclear
SEPT7 septin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TP53 tumor protein p53
UBE2A ubiquitin-conjugating enzyme E2A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6