cdkn1a Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cyclin-dependent kinase inhibitor 1A (p21, Cip1)|This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 1026)
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Genes

31 genes co-occuring with the biological term cdkn1a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ARID1A AT rich interactive domain 1A (SWI-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATR ATR serine/threonine kinase
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELAVL1 ELAV like RNA binding protein 1
FALEC focally amplified long non-coding RNA in epithelial cancer
GADD45A growth arrest and DNA-damage-inducible, alpha
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
LCMT2 leucine carboxyl methyltransferase 2
LCOR ligand dependent nuclear receptor corepressor
MIR22 microRNA 22
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POU2F1 POU class 2 homeobox 1
SHROOM2 shroom family member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SP1 Sp1 transcription factor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TP53 tumor protein p53
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
ZBTB16 zinc finger and BTB domain containing 16
ZBTB8A zinc finger and BTB domain containing 8A
ZNHIT1 zinc finger, HIT-type containing 1