cefalotin Gene Set

Dataset	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category	transcriptomics
Type	small molecule perturbation
Description	A semisynthetic, first-generation cephalosporin antibiotic with acetoxymethyl and (2-thienylacetyl)nitrilo moieties at positions 3 and 7, respectively, of the core structure. Administered parenterally during surgery and to treat a wide spectrum of blood infections. (Chemical Entities of Biological Interest Ontology, CHEBI_124991)
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Genes

13 genes differentially expressed following the cefalotin small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol	Name	Standardized Value
SYNGR3	synaptogyrin 3	4.37918
PLSCR1	phospholipid scramblase 1	3.85719
ISOC1	isochorismatase domain containing 1	3.55387
DISC1	disrupted in schizophrenia 1	3.27598
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	3.21975

decreased expression

Symbol	Name	Standardized Value
IARS2	isoleucyl-tRNA synthetase 2, mitochondrial	-5.57429
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	-4.89979
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	-4.54959
ELP6	elongator acetyltransferase complex subunit 6	-3.84561
ZDHHC6	zinc finger, DHHC-type containing 6	-3.54677
TIMP2	TIMP metallopeptidase inhibitor 2	-3.43612
TRAPPC6A	trafficking protein particle complex 6A	-3.35696
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	-3.17313