cefepime-6237 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the cefepime-6237 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTL8 actin-like 8
ADAM17 ADAM metallopeptidase domain 17
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
AIM1L absent in melanoma 1-like
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANGPT4 angiopoietin 4
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BCL2A1 BCL2-related protein A1
BMP4 bone morphogenetic protein 4
C1QB complement component 1, q subcomponent, B chain
CALML3 calmodulin-like 3
CASP8 caspase 8, apoptosis-related cysteine peptidase
CD6 CD6 molecule
CD8B CD8b molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CDH10 cadherin 10, type 2 (T2-cadherin)
CHN2 chimerin 2
CIR1 corepressor interacting with RBPJ, 1
CLCA1 chloride channel accessory 1
CLCF1 cardiotrophin-like cytokine factor 1
CLCN3 chloride channel, voltage-sensitive 3
CTSZ cathepsin Z
DNAH17 dynein, axonemal, heavy chain 17
DSPP dentin sialophosphoprotein
ERAP1 endoplasmic reticulum aminopeptidase 1
ETNK2 ethanolamine kinase 2
FAM120C family with sequence similarity 120C
FAM214B family with sequence similarity 214, member B
FGFR2 fibroblast growth factor receptor 2
FLCN folliculin
FLOT1 flotillin 1
FRMD1 FERM domain containing 1
FSCN1 fascin actin-bundling protein 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GGT1 gamma-glutamyltransferase 1
GPC3 glypican 3
GRM8 glutamate receptor, metabotropic 8
GSPT1 G1 to S phase transition 1
HCFC1 host cell factor C1
HIPK2 homeodomain interacting protein kinase 2
HIST1H2AJ histone cluster 1, H2aj
ICAM1 intercellular adhesion molecule 1
IFT54 intraflagellar transport 54
IL23A interleukin 23, alpha subunit p19
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KRIT1 KRIT1, ankyrin repeat containing
LAPTM5 lysosomal protein transmembrane 5
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRN3 leucine rich repeat neuronal 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MRPS18C mitochondrial ribosomal protein S18C
MTA2 metastasis associated 1 family, member 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYOD1 myogenic differentiation 1
PBX2 pre-B-cell leukemia homeobox 2
PDGFD platelet derived growth factor D
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHLDB1 pleckstrin homology-like domain, family B, member 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRSS53 protease, serine, 53
PSG9 pregnancy specific beta-1-glycoprotein 9
PTK6 protein tyrosine kinase 6
RAB3D RAB3D, member RAS oncogene family
RCN3 reticulocalbin 3, EF-hand calcium binding domain
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPGR retinitis pigmentosa GTPase regulator
RPLP2 ribosomal protein, large, P2
RUNX1 runt-related transcription factor 1
SAMD9 sterile alpha motif domain containing 9
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFTPC surfactant protein C
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIX1 SIX homeobox 1
SNW1 SNW domain containing 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRY2 sprouty homolog 2 (Drosophila)
SSX1 synovial sarcoma, X breakpoint 1
SUGP1 SURP and G patch domain containing 1
TBX10 T-box 10
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCHH trichohyalin
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UTRN utrophin
VASH2 vasohibin 2
VAX2 ventral anterior homeobox 2
WSCD1 WSC domain containing 1
WWTR1 WW domain containing transcription regulator 1
ZNF117 zinc finger protein 117
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
AGBL5 ATP/GTP binding protein-like 5
AKR1C3 aldo-keto reductase family 1, member C3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BBC3 BCL2 binding component 3
C1ORF109 chromosome 1 open reading frame 109
C9ORF40 chromosome 9 open reading frame 40
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CLDND1 claudin domain containing 1
CLK2 CDC-like kinase 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COCH cochlin
COG4 component of oligomeric golgi complex 4
CXORF56 chromosome X open reading frame 56
DHDDS dehydrodolichyl diphosphate synthase
DHRS11 dehydrogenase/reductase (SDR family) member 11
DSE dermatan sulfate epimerase
DUSP8 dual specificity phosphatase 8
EVPL envoplakin
EXOC5 exocyst complex component 5
FA2H fatty acid 2-hydroxylase
FANCC Fanconi anemia, complementation group C
FBXW12 F-box and WD repeat domain containing 12
FOXK2 forkhead box K2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GMEB1 glucocorticoid modulatory element binding protein 1
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
INO80D INO80 complex subunit D
INSIG2 insulin induced gene 2
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0753 KIAA0753
KIAA0894 KIAA0894 protein
KRBOX4 KRAB box domain containing 4
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC642236 FSHD region gene 1 pseudogene
LYPD1 LY6/PLAUR domain containing 1
MAGEH1 melanoma antigen family H1
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP9 matrix metallopeptidase 9
MPI mannose phosphate isomerase
MYO9A myosin IXA
NOL6 nucleolar protein 6 (RNA-associated)
OCEL1 occludin/ELL domain containing 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIBF1 progesterone immunomodulatory binding factor 1
PLD3 phospholipase D family, member 3
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POR P450 (cytochrome) oxidoreductase
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
REPS2 RALBP1 associated Eps domain containing 2
RHOBTB1 Rho-related BTB domain containing 1
RNF31 ring finger protein 31
RNH1 ribonuclease/angiogenin inhibitor 1
RWDD2A RWD domain containing 2A
SETD6 SET domain containing 6
SGK1 serum/glucocorticoid regulated kinase 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNAI2 snail family zinc finger 2
SQRDL sulfide quinone reductase-like (yeast)
SREBF1 sterol regulatory element binding transcription factor 1
SSFA2 sperm specific antigen 2
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
SUN2 Sad1 and UNC84 domain containing 2
SYF2 SYF2 pre-mRNA-splicing factor
TDRD1 tudor domain containing 1
TGDS TDP-glucose 4,6-dehydratase
TMEM127 transmembrane protein 127
TMEM260 transmembrane protein 260
TOE1 target of EGR1, member 1 (nuclear)
TRAPPC2 trafficking protein particle complex 2
TRIM66 tripartite motif containing 66
UBXN6 UBX domain protein 6
USP36 ubiquitin specific peptidase 36
VCPKMT valosin containing protein lysine (K) methyltransferase
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WASF2 WAS protein family, member 2
WDR13 WD repeat domain 13
ZMAT5 zinc finger, matrin-type 5
ZMYM3 zinc finger, MYM-type 3
ZNF302 zinc finger protein 302
ZNF354A zinc finger protein 354A
ZNF408 zinc finger protein 408
ZNF668 zinc finger protein 668
ZNF675 zinc finger protein 675
ZNF768 zinc finger protein 768
ZNF8 zinc finger protein 8