cefuroxime-5787 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the cefuroxime-5787 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADCK2 aarF domain containing kinase 2
ADRA2B adrenoceptor alpha 2B
ANGPTL4 angiopoietin-like 4
APAF1 apoptotic peptidase activating factor 1
AQP7 aquaporin 7
ASPN asporin
ATP9A ATPase, class II, type 9A
AVP arginine vasopressin
BMP4 bone morphogenetic protein 4
BSN bassoon presynaptic cytomatrix protein
CARTPT CART prepropeptide
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDH10 cadherin 10, type 2 (T2-cadherin)
CELF3 CUGBP, Elav-like family member 3
CHAT choline O-acetyltransferase
CHI3L2 chitinase 3-like 2
CLCN4 chloride channel, voltage-sensitive 4
CLCN7 chloride channel, voltage-sensitive 7
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COL8A1 collagen, type VIII, alpha 1
CST4 cystatin S
CYBA cytochrome b-245, alpha polypeptide
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DGCR6L DiGeorge syndrome critical region gene 6-like
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DZIP1 DAZ interacting zinc finger protein 1
EMC1 ER membrane protein complex subunit 1
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM135A family with sequence similarity 135, member A
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPM6B glycoprotein M6B
HAO2 hydroxyacid oxidase 2 (long chain)
HFE hemochromatosis
HIF3A hypoxia inducible factor 3, alpha subunit
HLA-F major histocompatibility complex, class I, F
HNF1B HNF1 homeobox B
HRG histidine-rich glycoprotein
HRH2 histamine receptor H2
IFT27 intraflagellar transport 27
IL36RN interleukin 36 receptor antagonist
INA internexin neuronal intermediate filament protein, alpha
IQSEC2 IQ motif and Sec7 domain 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCTD14 potassium channel tetramerization domain containing 14
KIAA0319L KIAA0319-like
KIAA1109 KIAA1109
KLF4 Kruppel-like factor 4 (gut)
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LIN28A lin-28 homolog A (C. elegans)
LOC440895 two pore channel 3 pseudogene
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAP2K5 mitogen-activated protein kinase kinase 5
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRC2 mannose receptor, C type 2
NDN necdin, melanoma antigen (MAGE) family member
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPR1 natriuretic peptide receptor 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGDHL oxoglutarate dehydrogenase-like
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PID1 phosphotyrosine interaction domain containing 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP prolactin-induced protein
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
RAB6A RAB6A, member RAS oncogene family
RPL10 ribosomal protein L10
RPL18 ribosomal protein L18
SCN1B sodium channel, voltage gated, type I beta subunit
SEC14L5 SEC14-like 5 (S. cerevisiae)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH3BP2 SH3-domain binding protein 2
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SOCS3 suppressor of cytokine signaling 3
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPHK2 sphingosine kinase 2
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TIMELESS timeless circadian clock
TRO trophinin
TRPA1 transient receptor potential cation channel, subfamily A, member 1
WNT16 wingless-type MMTV integration site family, member 16
ZNF500 zinc finger protein 500
ZNF518A zinc finger protein 518A
ZNF613 zinc finger protein 613

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ACKR3 atypical chemokine receptor 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ATAT1 alpha tubulin acetyltransferase 1
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCL2L2 BCL2-like 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP15 bone morphogenetic protein 15
BRAF B-Raf proto-oncogene, serine/threonine kinase
C16ORF45 chromosome 16 open reading frame 45
C1R complement component 1, r subcomponent
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
C5ORF45 chromosome 5 open reading frame 45
C9ORF40 chromosome 9 open reading frame 40
CBX4 chromobox homolog 4
CEP170B centrosomal protein 170B
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
COBL cordon-bleu WH2 repeat protein
CPA4 carboxypeptidase A4
CSF1R colony stimulating factor 1 receptor
CSRNP3 cysteine-serine-rich nuclear protein 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CXCL3 chemokine (C-X-C motif) ligand 3
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DUSP8 dual specificity phosphatase 8
EIF5A2 eukaryotic translation initiation factor 5A2
ELOVL4 ELOVL fatty acid elongase 4
ERAP2 endoplasmic reticulum aminopeptidase 2
ERCC8 excision repair cross-complementation group 8
F3 coagulation factor III (thromboplastin, tissue factor)
FAM53B family with sequence similarity 53, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FRS3 fibroblast growth factor receptor substrate 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
HIST1H1D histone cluster 1, H1d
HIST1H2AG histone cluster 1, H2ag
HIST1H4C histone cluster 1, H4c
HIST1H4E histone cluster 1, H4e
HOXC8 homeobox C8
IDI2-AS1 IDI2 antisense RNA 1
IFNA17 interferon, alpha 17
IPO8 importin 8
IRAK4 interleukin-1 receptor-associated kinase 4
ITK IL2-inducible T-cell kinase
KRT86 keratin 86, type II
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LNPEP leucyl/cystinyl aminopeptidase
LOC257152 uncharacterized LOC257152
LOC390998 ribosomal protein L10 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MATN3 matrilin 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRPL44 mitochondrial ribosomal protein L44
MTA2 metastasis associated 1 family, member 2
MYLK myosin light chain kinase
MYO1F myosin IF
NARFL nuclear prelamin A recognition factor-like
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
PAQR6 progestin and adipoQ receptor family member VI
PARM1 prostate androgen-regulated mucin-like protein 1
PCDH17 protocadherin 17
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PNRC1 proline-rich nuclear receptor coactivator 1
POU3F2 POU class 3 homeobox 2
PRSS22 protease, serine, 22
PSKH1 protein serine kinase H1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAP1GAP2 RAP1 GTPase activating protein 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCAMP5 secretory carrier membrane protein 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SETBP1 SET binding protein 1
SIX1 SIX homeobox 1
SLC46A3 solute carrier family 46, member 3
SNTA1 syntrophin, alpha 1
SPEG SPEG complex locus
SPRYD7 SPRY domain containing 7
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TM6SF1 transmembrane 6 superfamily member 1
TMEM209 transmembrane protein 209
TMEM53 transmembrane protein 53
TTC30A tetratricopeptide repeat domain 30A
TUBA4B tubulin, alpha 4b
WWC2 WW and C2 domain containing 2
ZNF205 zinc finger protein 205
ZNF286A zinc finger protein 286A
ZNF428 zinc finger protein 428
ZNF862 zinc finger protein 862