celiac disease Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.|A food hypersensitivity that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. (Experimental Factor Ontology, EFO_0001060)
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Genes

87 genes associated with the disease celiac disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.31608
LPP LIM domain containing preferred translocation partner in lipoma 2.04444
ATXN2 ataxin 2 1.40682
OLIG3 oligodendrocyte transcription factor 3 1.30954
RGS1 regulator of G-protein signaling 1 1.22898
CCR3 chemokine (C-C motif) receptor 3 1.2206
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.11998
IL18RAP interleukin 18 receptor accessory protein 1.09588
TAGAP T-cell activation RhoGTPase activating protein 1.06123
IL21 interleukin 21 1.02486
PTPRK protein tyrosine phosphatase, receptor type, K 0.995303
SH2B3 SH2B adaptor protein 3 0.968307
IL18R1 interleukin 18 receptor 1 0.932337
PUS10 pseudouridylate synthase 10 0.923046
KIAA1109 KIAA1109 0.894262
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.790827
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.752991
RUNX3 runt-related transcription factor 3 0.69843
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.69843
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.682635
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.670996
ZMIZ1 zinc finger, MIZ-type containing 1 0.63666
IL12A interleukin 12A 0.63207
ICOSLG inducible T-cell co-stimulator ligand 0.602429
MMEL1 membrane metallo-endopeptidase-like 1 0.58494
CCR4 chemokine (C-C motif) receptor 4 0.58494
C1ORF106 chromosome 1 open reading frame 106 0.572184
ICOS inducible T-cell co-stimulator 0.552621
PLEK pleckstrin 0.537125
ARHGAP31 Rho GTPase activating protein 31 0.537125
RMI2 RecQ mediated genome instability 2 0.464771
XCR1 chemokine (C motif) receptor 1 0.438544
LRRC2 leucine rich repeat containing 2 0.429338
TMSB4X thymosin beta 4, X-linked 0.429338
PARK7 parkinson protein 7 0.408752
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.403461
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.403461
NFIA nuclear factor I/A 0.403461
LTF lactotransferrin 0.403461
IL2 interleukin 2 0.403461
CD247 CD247 molecule 0.403461
YDJC YdjC homolog (bacterial) 0.368757
ELMO1 engulfment and cell motility 1 0.368757
FRMD4B FERM domain containing 4B 0.368757
CCR2 chemokine (C-C motif) receptor 2 0.345945
BRAP BRCA1 associated protein 0.345945
MYNN myoneurin 0.345945
HECA headcase homolog (Drosophila) 0.327313
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.327313
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.297866
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.285417
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.285417
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.274608
LRRIQ4 leucine-rich repeats and IQ motif containing 4 0.264872
SOX6 SRY (sex determining region Y)-box 6 0.264872
PLXNA4 plexin A4 0.256228
ZNF639 zinc finger protein 639 0.256228
FYCO1 FYVE and coiled-coil domain containing 1 0.256228
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.256228
XPO1 exportin 1 0.256228
WNT3 wingless-type MMTV integration site family, member 3 0.256228
TTC34 tetratricopeptide repeat domain 34 0.256228
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.197766
SCHIP1 schwannomin interacting protein 1 0.197766
DCC DCC netrin 1 receptor 0.197766
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.197766
USP34 ubiquitin specific peptidase 34 0.197766
AJAP1 adherens junctions associated protein 1 0.197766
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.197766
TG thyroglobulin 0.15771
CUX2 cut-like homeobox 2 0.15771
C6ORF99 chromosome 6 open reading frame 99 0.15771
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.15771
ALPK2 alpha-kinase 2 0.126165
ZFP36L1 ZFP36 ring finger protein-like 1 0.126165
PRMT2IP PRMT2 interacting protein 0.126165
NCALD neurocalcin delta 0.126165
IL33R interleukin 33 receptor 0.100789
AMY1A amylase, alpha 1A (salivary) 0.100789
IRF4 interferon regulatory factor 4 0.100789
CRH corticotropin releasing hormone 0.100789
CD274 CD274 molecule 0.080593
CD80 CD80 molecule 0.052255
SPANXN3 SPANX family, member N3 0.052255
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.052255
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.052255
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.043246