celiac disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.|A food hypersensitivity that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. (Experimental Factor Ontology, EFO_0001060)
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Genes

275 genes co-occuring with the disease celiac disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CD79A CD79a molecule, immunoglobulin-associated alpha 2.99342
TGM2 transglutaminase 2 2.48847
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.84954
HLA-C major histocompatibility complex, class I, C 1.80607
MYO9B myosin IXB 1.80021
LCT lactase 1.68226
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.59474
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.45353
IL18RAP interleukin 18 receptor accessory protein 1.38821
CD4 CD4 molecule 1.35463
TAGAP T-cell activation RhoGTPase activating protein 1.3241
MICA MHC class I polypeptide-related sequence A 1.30663
PREP prolyl endopeptidase 1.2765
SH2B3 SH2B adaptor protein 3 1.25602
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.24211
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.20569
IL15 interleukin 15 1.16992
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 1.15922
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.1541
ALPPL2 alkaline phosphatase, placental-like 2 1.12108
ALPP alkaline phosphatase, placental 1.12066
ALPL alkaline phosphatase, liver/bone/kidney 1.11982
RGS1 regulator of G-protein signaling 1 1.09293
CSN1S1 casein alpha s1 1.0774
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.06144
LPP LIM domain containing preferred translocation partner in lipoma 1.03367
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.999924
KIAA1109 KIAA1109 0.996549
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.984321
ALB albumin 0.983479
TGM1 transglutaminase 1 0.979689
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.941196
TJP1 tight junction protein 1 0.941196
HLA-A major histocompatibility complex, class I, A 0.938289
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.928346
FOXP3 forkhead box P3 0.925452
TRAC T cell receptor alpha constant 0.918024
TPO thyroid peroxidase 0.903621
PTH parathyroid hormone 0.878605
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.870006
PARD3 par-3 family cell polarity regulator 0.860999
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.858952
SI sucrase-isomaltase (alpha-glucosidase) 0.851173
FTL ferritin, light polypeptide 0.849126
FTH1 ferritin, heavy polypeptide 1 0.849126
CCK cholecystokinin 0.844211
INS insulin 0.839705
NCAM1 neural cell adhesion molecule 1 0.834378
TRBV9 T cell receptor beta variable 9 0.813052
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast) 0.813052
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.811001
CD7 CD7 molecule 0.802795
TGM6 transglutaminase 6 0.800744
IL21 interleukin 21 0.799513
CELA1 chymotrypsin-like elastase family, member 1 0.770844
MLN motilin 0.764718
CELA3B chymotrypsin-like elastase family, member 3B 0.763494
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.757786
THEMIS thymocyte selection associated 0.756156
GAST gastrin 0.752898
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.735433
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.735433
LALBA lactalbumin, alpha- 0.733406
TMPRSS15 transmembrane protease, serine 15 0.730571
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 0.728143
WDR11 WD repeat domain 11 0.720865
SSUH2 ssu-2 homolog (C. elegans) 0.713198
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 0.712796
OCLN occludin 0.692697
CLEC16A C-type lectin domain family 16, member A 0.692697
CALR calreticulin 0.677903
TGFB1 transforming growth factor, beta 1 0.677504
TG thyroglobulin 0.670333
TFRC transferrin receptor 0.66755
GIF gastric intrinsic factor (vitamin B synthesis) 0.666358
ALPI alkaline phosphatase, intestinal 0.662784
GIP gastric inhibitory polypeptide 0.631598
CCR9 chemokine (C-C motif) receptor 9 0.629635
ZNF347 zinc finger protein 347 0.629635
CLDN2 claudin 2 0.616703
LAP3 leucine aminopeptidase 3 0.607714
TLR4 toll-like receptor 4 0.603811
IGHV1-2 immunoglobulin heavy variable 1-2 0.6003
TBX21 T-box 21 0.59952
TNF tumor necrosis factor 0.595623
RAET1G retinoic acid early transcript 1G 0.595623
KLC3 kinesin light chain 3 0.587833
PUS10 pseudouridylate synthase 10 0.578494
TGM3 transglutaminase 3 0.578494
CD83 CD83 molecule 0.574994
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.57305
TREH trehalase (brush-border membrane glycoprotein) 0.564889
SPINK4 serine peptidase inhibitor, Kazal type 4 0.550134
ICAM1 intercellular adhesion molecule 1 0.549747
IFNG interferon, gamma 0.548195
A1BG alpha-1-B glycoprotein 0.547419
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.54393
ANPEP alanyl (membrane) aminopeptidase 0.540055
OLIG3 oligodendrocyte transcription factor 3 0.539667
FRMD4B FERM domain containing 4B 0.539667
PTPRD protein tyrosine phosphatase, receptor type, D 0.536957
IGHA1 immunoglobulin heavy constant alpha 1 0.533088
IL2RA interleukin 2 receptor, alpha 0.531541
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.529994
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.529608
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 0.528063
CSAG1 chondrosarcoma associated gene 1 0.527676
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.521502
LAD1 ladinin 1 0.520731
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.50689
IL1B interleukin 1, beta 0.505739
IL10 interleukin 10 0.504973
GHRL ghrelin/obestatin prepropeptide 0.495411
MICB MHC class I polypeptide-related sequence B 0.490072
HLA-B major histocompatibility complex, class I, B 0.487407
HLA-E major histocompatibility complex, class I, E 0.482464
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.481325
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 0.476393
CD86 CD86 molecule 0.474498
IL18R1 interleukin 18 receptor 1 0.472604
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.470711
SST somatostatin 0.467306
SH2B2 SH2B adaptor protein 2 0.465038
LYZ lysozyme 0.460883
PRF1 perforin 1 (pore forming protein) 0.455224
IGF1 insulin-like growth factor 1 (somatomedin C) 0.450324
CD80 CD80 molecule 0.443923
DEFB1 defensin, beta 1 0.438282
F2 coagulation factor II (thrombin) 0.437154
METTL21B methyltransferase like 21B 0.436778
GGT1 gamma-glutamyltransferase 1 0.419517
CD226 CD226 molecule 0.413153
FASLG Fas ligand (TNF superfamily, member 6) 0.411283
ZMIZ1 zinc finger, MIZ-type containing 1 0.408666
CCR3 chemokine (C-C motif) receptor 3 0.408292
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.406425
CHM choroideremia (Rab escort protein 1) 0.405678
NGLY1 N-glycanase 1 0.405305
ELMO1 engulfment and cell motility 1 0.402318
CLDN3 claudin 3 0.397098
RNASE3 ribonuclease, RNase A family, 3 0.395235
SYMPK symplekin 0.393746
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.392257
NKX2-3 NK2 homeobox 3 0.391513
PBX3 pre-B-cell leukemia homeobox 3 0.388538
IRF1 interferon regulatory factor 1 0.378143
LTF lactotransferrin 0.372587
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.369628
IL2 interleukin 2 0.365193
PYY peptide YY 0.362978
SOX13 SRY (sex determining region Y)-box 13 0.360026
IL23R interleukin 23 receptor 0.35892
IL18 interleukin 18 0.357814
CD8A CD8a molecule 0.354499
CTSW cathepsin W 0.353395
B3GAT1 beta-1,3-glucuronyltransferase 1 0.352659
GLS glutaminase 0.352291
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.349717
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.347144
TBC1D7 TBC1 domain family, member 7 0.346777
HLA-DMA major histocompatibility complex, class II, DM alpha 0.346409
CLDN4 claudin 4 0.340173
BGLAP bone gamma-carboxyglutamate (gla) protein 0.336876
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.32774
KRT37 keratin 37, type I 0.32774
SPPL2A signal peptide peptidase like 2A 0.327375
IL12RB1 interleukin 12 receptor, beta 1 0.320454
INSM2 insulinoma-associated 2 0.315729
CAPZB capping protein (actin filament) muscle Z-line, beta 0.315003
PGPEP1 pyroglutamyl-peptidase I 0.312102
IFIH1 interferon induced with helicase C domain 1 0.312102
TBX1 T-box 1 0.311739
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.309204
ACD adrenocortical dysplasia homolog (mouse) 0.30848
IL12RB2 interleukin 12 receptor, beta 2 0.305948
FN1 fibronectin 1 0.302698
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.300533
DERL3 derlin 3 0.300173
REG3A regenerating islet-derived 3 alpha 0.299812
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.295492
HFE hemochromatosis 0.294413
IL17RE interleukin 17 receptor E 0.29118
C4A complement component 4A (Rodgers blood group) 0.290821
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.285444
NELFCD negative elongation factor complex member C/D 0.281153
PPY pancreatic polypeptide 0.280439
PRSS16 protease, serine, 16 (thymus) 0.279367
PRSS3 protease, serine, 3 0.275801
NTS neurotensin 0.273664
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.270819
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.270464
LHFP lipoma HMGIC fusion partner 0.270464
ANKRD55 ankyrin repeat domain 55 0.268332
DPP4 dipeptidyl-peptidase 4 0.267977
ICOSLG inducible T-cell co-stimulator ligand 0.265494
MPHOSPH9 M-phase phosphoprotein 9 0.264431
TLR2 toll-like receptor 2 0.261599
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.25877
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.257711
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.255946
GGT6 gamma-glutamyltransferase 6 0.255594
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.249608
CRTAM cytotoxic and regulatory T cell molecule 0.249257
ABR active BCR-related 0.24715
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 0.245396
GGTLC1 gamma-glutamyltransferase light chain 1 0.245046
VTCN1 V-set domain containing T cell activation inhibitor 1 0.243995
AIRE autoimmune regulator 0.243295
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.242595
TSPAN31 tetraspanin 31 0.240847
LEP leptin 0.240497
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.236312
CD44 CD44 molecule (Indian blood group) 0.235616
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 0.235616
MMP3 matrix metallopeptidase 3 0.22937
USP8 ubiquitin specific peptidase 8 0.228333
GLI1 GLI family zinc finger 1 0.227988
CCL25 chemokine (C-C motif) ligand 25 0.225917
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 0.225229
CIITA class II, major histocompatibility complex, transactivator 0.22145
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0.217693
MUC15 mucin 15, cell surface associated 0.217352
GLS2 glutaminase 2 (liver, mitochondrial) 0.214636
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.214297
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.213283
UBASH3A ubiquitin associated and SH3 domain containing A 0.212271
NOD2 nucleotide-binding oligomerization domain containing 2 0.211934
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.211261
TJP3 tight junction protein 3 0.210589
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.208245
IL17A interleukin 17A 0.207245
BHMT2 betaine--homocysteine S-methyltransferase 2 0.20658
TSFM Ts translation elongation factor, mitochondrial 0.205916
MBL2 mannose-binding lectin (protein C) 2, soluble 0.204593
GGT5 gamma-glutamyltransferase 5 0.202946
CD69 CD69 molecule 0.201962
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.201635
NLRP1 NLR family, pyrin domain containing 1 0.200656
RPL19 ribosomal protein L19 0.196779
CGN cingulin 0.196459
IL6 interleukin 6 0.19582
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.195501
CD5 CD5 molecule 0.192344
MIR192 microRNA 192 0.191408
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.191408
HLA-G major histocompatibility complex, class I, G 0.191097
MANEAL mannosidase, endo-alpha-like 0.189859
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.188022
PPP6C protein phosphatase 6, catalytic subunit 0.183835
MMP1 matrix metallopeptidase 1 0.182666
COG6 component of oligomeric golgi complex 6 0.181798
GGT7 gamma-glutamyltransferase 7 0.180652
SZRD1 SUZ RNA binding domain containing 1 0.17952
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.178403
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.178403
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.178126
CD52 CD52 molecule 0.175679
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.175411
MARVELD2 MARVEL domain containing 2 0.168854
TLR3 toll-like receptor 3 0.168148
IRGM immunity-related GTPase family, M 0.167682
CD3D CD3d molecule, delta (CD3-TCR complex) 0.166995
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.166995
SDC4 syndecan 4 0.166768
COL1A2 collagen, type I, alpha 2 0.165655
IL1A interleukin 1, alpha 0.165217
RORC RAR-related orphan receptor C 0.165217
CD163 CD163 molecule 0.162109
PTPRK protein tyrosine phosphatase, receptor type, K 0.161716
CCL14 chemokine (C-C motif) ligand 14 0.161331
CXCR3 chemokine (C-X-C motif) receptor 3 0.160387
MMP12 matrix metallopeptidase 12 0.159838
CD68 CD68 molecule 0.159124
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.158434
IGFBP3 insulin-like growth factor binding protein 3 0.158266