celiac disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.|A food hypersensitivity that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. (Experimental Factor Ontology, EFO_0001060)
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Genes

130 genes associated with the disease celiac disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADAD1 adenosine deaminase domain containing 1 (testis-specific)
AHSA2 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
ARHGAP31 Rho GTPase activating protein 31
ATXN2 ataxin 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR9 chemokine (C-C motif) receptor 9
CCRL2 chemokine (C-C motif) receptor-like 2
CD14 CD14 molecule
CD247 CD247 molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD80 CD80 molecule
CIITA class II, major histocompatibility complex, transactivator
CLEC16A C-type lectin domain family 16, member A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DEFB103A defensin, beta 103A
DEFB104A defensin, beta 104A
DMPK dystrophia myotonica-protein kinase
ELMO1 engulfment and cell motility 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF1 fibroblast growth factor 1 (acidic)
FRMD4B FERM domain containing 4B
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
HLA-G major histocompatibility complex, class I, G
HP haptoglobin
ICOS inducible T-cell co-stimulator
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IK IK cytokine, down-regulator of HLA II
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL17B interleukin 17B
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL18RAP interleukin 18 receptor accessory protein
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL3 interleukin 3
IL33R interleukin 33 receptor
IL36R interleukin 36 receptor
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL9 interleukin 9
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAKMIP2 janus kinase and microtubule interacting protein 2
KIAA1109 KIAA1109
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LPP LIM domain containing preferred translocation partner in lipoma
LTA lymphotoxin alpha
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MBL2 mannose-binding lectin (protein C) 2, soluble
MICA MHC class I polypeptide-related sequence A
MMEL1 membrane metallo-endopeptidase-like 1
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYNN myoneurin
MYO9B myosin IXB
NFIA nuclear factor I/A
NOD2 nucleotide-binding oligomerization domain containing 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PARK7 parkinson protein 7
PLEK pleckstrin
POGLUT1 protein O-glucosyltransferase 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRK protein tyrosine phosphatase, receptor type, K
PUS10 pseudouridylate synthase 10
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS1 regulator of G-protein signaling 1
RUNX3 runt-related transcription factor 3
SCHIP1 schwannomin interacting protein 1
SH2B3 SH2B adaptor protein 3
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
SOCS1 suppressor of cytokine signaling 1
SPINK1 serine peptidase inhibitor, Kazal type 1
STK32A serine/threonine kinase 32A
TAGAP T-cell activation RhoGTPase activating protein
TCERG1 transcription elongation regulator 1
TGFB1 transforming growth factor, beta 1
THEMIS thymocyte selection associated
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2L3 ubiquitin-conjugating enzyme E2L 3
WNT3 wingless-type MMTV integration site family, member 3
YDJC YdjC homolog (bacterial)
YIPF5 Yip1 domain family, member 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1