celiac disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.|A food hypersensitivity that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.|A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. (Experimental Factor Ontology, EFO_0001060)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:10608
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Genes

208 genes associated with the disease celiac disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.55968
LPP LIM domain containing preferred translocation partner in lipoma 2.54818
KIAA1109 KIAA1109 2.20601
SH2B3 SH2B adaptor protein 3 2.04056
ATXN2 ataxin 2 2.03641
PTPRK protein tyrosine phosphatase, receptor type, K 1.95755
ZMIZ1 zinc finger, MIZ-type containing 1 1.88503
PUS10 pseudouridylate synthase 10 1.85141
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.84833
TAGAP T-cell activation RhoGTPase activating protein 1.81474
TRAF1 TNF receptor-associated factor 1 1.75993
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.68078
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.65612
MMEL1 membrane metallo-endopeptidase-like 1 1.65417
ANKRD55 ankyrin repeat domain 55 1.63944
IL2RA interleukin 2 receptor, alpha 1.63004
CCR6 chemokine (C-C motif) receptor 6 1.62834
CD247 CD247 molecule 1.62029
TNPO3 transportin 3 1.60057
YDJC YdjC homolog (bacterial) 1.54533
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.53785
STAT4 signal transducer and activator of transcription 4 1.53704
SPRED2 sprouty-related, EVH1 domain containing 2 1.52889
IRF4 interferon regulatory factor 4 1.49081
ICOSLG inducible T-cell co-stimulator ligand 1.48714
CD40 CD40 molecule, TNF receptor superfamily member 5 1.47528
UBASH3A ubiquitin associated and SH3 domain containing A 1.47287
ICOS inducible T-cell co-stimulator 1.44922
PLEK pleckstrin 1.43667
ARHGAP31 Rho GTPase activating protein 31 1.43537
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.41627
KIF5A kinesin family member 5A 1.40141
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.39687
ELMO1 engulfment and cell motility 1 1.39148
C1ORF106 chromosome 1 open reading frame 106 1.38067
TMEM187 transmembrane protein 187 1.37871
C5ORF30 chromosome 5 open reading frame 30 1.35709
FAM107A family with sequence similarity 107, member A 1.35132
ZFP36L1 ZFP36 ring finger protein-like 1 1.35025
NFIA nuclear factor I/A 1.31635
FRMD4B FERM domain containing 4B 1.28906
GLB1 galactosidase, beta 1 1.28041
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.27258
PPP1R12B protein phosphatase 1, regulatory subunit 12B 1.26953
MYNN myoneurin 1.24194
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.22596
IFI16 interferon, gamma-inducible protein 16 1.21019
WNT3 wingless-type MMTV integration site family, member 3 1.19386
TPTE transmembrane phosphatase with tensin homology 1.14463
CD28 CD28 molecule 1.14182
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 1.11813
TG thyroglobulin 1.10419
ALPK2 alpha-kinase 2 1.08533
RUNX3 runt-related transcription factor 3 1.08211
MTTP microsomal triglyceride transfer protein 1.04846
KLK2 kallikrein-related peptidase 2 1.02476
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 1.00886
HYDIN HYDIN, axonemal central pair apparatus protein 1.00407
STK32B serine/threonine kinase 32B 0.986376
TGFBR3 transforming growth factor, beta receptor III 0.982352
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.951514
CNTN4 contactin 4 0.947208
PRKCZ protein kinase C, zeta 0.946163
NTM neurotrimin 0.940135
LINC00466 long intergenic non-protein coding RNA 466 0.888428
IL18RAP interleukin 18 receptor accessory protein 0.877396
NUP98 nucleoporin 98kDa 0.869084
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.865448
GFRA1 GDNF family receptor alpha 1 0.861462
LOC284395 uncharacterized LOC284395 0.853791
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.845188
PTCHD4 patched domain containing 4 0.842929
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.839855
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 0.837718
MTCH1 mitochondrial carrier 1 0.823134
ITPK1 inositol-tetrakisphosphate 1-kinase 0.818753
RYR3 ryanodine receptor 3 0.815307
POU2F1 POU class 2 homeobox 1 0.808055
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.806323
LINGO2 leucine rich repeat and Ig domain containing 2 0.801304
FOXD3 forkhead box D3 0.79563
RGS1 regulator of G-protein signaling 1 0.79563
MAML3 mastermind-like 3 (Drosophila) 0.787593
ARHGAP44 Rho GTPase activating protein 44 0.786312
BCRP2 breakpoint cluster region pseudogene 2 0.777475
LTF lactotransferrin 0.769887
TSPAN18 tetraspanin 18 0.769887
WWOX WW domain containing oxidoreductase 0.769617
TIPRL TOR signaling pathway regulator 0.767882
FERMT1 fermitin family member 1 0.76125
BTN3A2 butyrophilin, subfamily 3, member A2 0.753433
CCDC91 coiled-coil domain containing 91 0.747619
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.743756
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.743048
DNAH8 dynein, axonemal, heavy chain 8 0.743048
PGM1 phosphoglucomutase 1 0.740032
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.736216
MOB3B MOB kinase activator 3B 0.727538
BCL2 B-cell CLL/lymphoma 2 0.7253
THEMIS thymocyte selection associated 0.720532
KIFAP3 kinesin-associated protein 3 0.712762
KCNK10 potassium channel, two pore domain subfamily K, member 10 0.70719
PCDH11Y protocadherin 11 Y-linked 0.707003
SNED1 sushi, nidogen and EGF-like domains 1 0.70663
UNC5C unc-5 homolog C (C. elegans) 0.70663
ADGRL2 adhesion G protein-coupled receptor L2 0.705703
MACROD2 MACRO domain containing 2 0.699446
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.698071
LOH12CR1 loss of heterozygosity, 12, chromosomal region 1 0.691618
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 0.691297
POLN polymerase (DNA directed) nu 0.689711
LCT lactase 0.687994
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.683898
OPHN1 oligophrenin 1 0.675623
MYO5A myosin VA (heavy chain 12, myoxin) 0.673322
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.672258
VAV3 vav 3 guanine nucleotide exchange factor 0.671993
ZNF496 zinc finger protein 496 0.669747
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.665868
KIAA1644 KIAA1644 0.663947
CPM carboxypeptidase M 0.660239
FFAR4 free fatty acid receptor 4 0.658446
NCR2 natural cytotoxicity triggering receptor 2 0.656693
WT1 Wilms tumor 1 0.656693
NELL1 NEL-like 1 (chicken) 0.655831
PDE8A phosphodiesterase 8A 0.651654
SHISA9 shisa family member 9 0.650844
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.650844
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.647686
FAM24A family with sequence similarity 24, member A 0.644215
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.642063
LAMA2 laminin, alpha 2 0.641537
WSCD1 WSC domain containing 1 0.641537
DNAH12 dynein, axonemal, heavy chain 12 0.639985
HPSE2 heparanase 2 (inactive) 0.636995
KANK4 KN motif and ankyrin repeat domains 4 0.636511
LIN7A lin-7 homolog A (C. elegans) 0.634612
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.632771
VIM vimentin 0.631872
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.629714
UROC1 urocanate hydratase 1 0.628481
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.626482
PKN2 protein kinase N2 0.624931
CARD11 caspase recruitment domain family, member 11 0.623422
NTNG1 netrin G1 0.622315
L3MBTL4 l(3)mbt-like 4 (Drosophila) 0.620165
PPARA peroxisome proliferator-activated receptor alpha 0.61912
ATXN1 ataxin 1 0.618434
BMPR1B bone morphogenetic protein receptor, type IB 0.617086
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 0.616754
TGFB2 transforming growth factor, beta 2 0.615445
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.615445
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.614068
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.613722
UBE2Q2P1 ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 1 0.613722
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.612357
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.611686
PVR poliovirus receptor 0.611686
BID BH3 interacting domain death agonist 0.611023
RGS10 regulator of G-protein signaling 10 0.605359
BTN2A1 butyrophilin, subfamily 2, member A1 0.60506
TGM3 transglutaminase 3 0.60506
GRIK4 glutamate receptor, ionotropic, kainate 4 0.604465
PRR5L proline rich 5 like 0.603584
KIAA1217 KIAA1217 0.603005
LOC100506274 uncharacterized LOC100506274 0.60243
OR51E2 olfactory receptor, family 51, subfamily E, member 2 0.601018
E2F3 E2F transcription factor 3 0.601018
ADI1 acireductone dioxygenase 1 0.59964
SOX2-OT SOX2 overlapping transcript 0.599097
PDPN podoplanin 0.598827
VWC2L von Willebrand factor C domain containing protein 2-like 0.596242
CAPN14 calpain 14 0.595401
METTL18 methyltransferase like 18 0.594847
CAGE1 cancer antigen 1 0.594297
DNAH14 dynein, axonemal, heavy chain 14 0.592411
PRUNE2 prune homolog 2 (Drosophila) 0.592146
FAM135B family with sequence similarity 135, member B 0.592146
VSTM4 V-set and transmembrane domain containing 4 0.591358
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.591098
DOK6 docking protein 6 0.591098
ADRA1B adrenoceptor alpha 1B 0.590323
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 0.590323
TFIP11 tuftelin interacting protein 11 0.589557
DGKG diacylglycerol kinase, gamma 90kDa 0.588801
KIAA0319 KIAA0319 0.588551
NUAK1 NUAK family, SNF1-like kinase, 1 0.588551
SRRD SRR1 domain containing 0.588302
NRXN3 neurexin 3 0.587807
IGSF23 immunoglobulin superfamily, member 23 0.587071
MAGED1 melanoma antigen family D1 0.587071
MIER1 mesoderm induction early response 1, transcriptional regulator 0.57331
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.566055
SIL1 SIL1 nucleotide exchange factor 0.560729
SYT1 synaptotagmin I 0.552872
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.549267
MIR99AHG mir-99a-let-7c cluster host gene 0.545697
PRDM10 PR domain containing 10 0.542281
NRROS negative regulator of reactive oxygen species 0.541213
COX20 COX20 cytochrome c oxidase assembly factor 0.539271
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.538104
PRAM1 PML-RARA regulated adaptor molecule 1 0.535408
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.533758
DCN decorin 0.531096
RNF213 ring finger protein 213 0.52333
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.501764
ARMC9 armadillo repeat containing 9 0.500605
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 0.499347