cell aging Gene Set

Dataset GO Biological Process Annotations 2015
Category structural or functional annotations
Type biological process
Description An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). (Gene Ontology, GO_0007569)
External Link http://amigo.geneontology.org/amigo/term/GO:0007569
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Genes

60 genes participating in the cell aging biological process from the curated GO Biological Process Annotations 2015 dataset.

Symbol Name
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BRCA2 breast cancer 2, early onset
C2ORF40 chromosome 2 open reading frame 40
CALR calreticulin
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CTC1 CTS telomere maintenance complex component 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ENG endoglin
ERCC1 excision repair cross-complementation group 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
HTT huntingtin
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ILK integrin-linked kinase
KAT6A K(lysine) acetyltransferase 6A
LIMS1 LIM and senescent cell antigen-like domains 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MME membrane metallo-endopeptidase
MNT MAX network transcriptional repressor
MORC3 MORC family CW-type zinc finger 3
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
NUP62 nucleoporin 62kDa
OPA1 optic atrophy 1 (autosomal dominant)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PML promyelocytic leukemia
PRELP proline/arginine-rich end leucine-rich repeat protein
PRKCD protein kinase C, delta
ROMO1 reactive oxygen species modulator 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SMC5 structural maintenance of chromosomes 5
SMC6 structural maintenance of chromosomes 6
SOD1 superoxide dismutase 1, soluble
SRF serum response factor (c-fos serum response element-binding transcription factor)
TBX2 T-box 2
TBX3 T-box 3
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TP63 tumor protein p63
ULK3 unc-51 like kinase 3
WNT16 wingless-type MMTV integration site family, member 16
WRN Werner syndrome, RecQ helicase-like
ZMIZ1 zinc finger, MIZ-type containing 1