cell-cell junction Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals. (Gene Ontology, GO_0005911)
External Link http://amigo.geneontology.org/amigo/term/GO:0005911
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Genes

317 proteins localized to the cell-cell junction cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
ABI2 abl-interactor 2
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ADAM17 ADAM metallopeptidase domain 17
ADD1 adducin 1 (alpha)
ADGRB1 adhesion G protein-coupled receptor B1
ADGRL3 adhesion G protein-coupled receptor L3
AFDN afadin, adherens junction formation factor
AHI1 Abelson helper integration site 1
AHNAK AHNAK nucleoprotein
AJAP1 adherens junctions associated protein 1
AJM1 apical junction component 1 homolog
AJUBA ajuba LIM protein
ALOX15B arachidonate 15-lipoxygenase, type B
AMTN amelotin
ANKRD42-DT ANKRD42 divergent transcript
ANXA1 annexin A1
ANXA2 annexin A2
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
AQP7 aquaporin 7
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAIAP2 BAI1-associated protein 2
BAIAP2L1 BAI1-associated protein 2-like 1
BAIAP2L2 BAI1-associated protein 2-like 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CADM1 cell adhesion molecule 1
CADM3 cell adhesion molecule 3
CADM4 cell adhesion molecule 4
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCDC85A coiled-coil domain containing 85A
CCDC85B coiled-coil domain containing 85B
CCDC85C coiled-coil domain containing 85C
CCN3 cellular communication network factor 3
CD53 CD53 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA3 cell division cycle associated 3
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH12 cadherin 12, type 2 (N-cadherin 2)
CDH13 cadherin 13
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDH18 cadherin 18, type 2
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH20 cadherin 20, type 2
CDH22 cadherin 22, type 2
CDH24 cadherin 24, type 2
CDH26 cadherin 26
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDH8 cadherin 8, type 2
CDH9 cadherin 9, type 2 (T1-cadherin)
CDHR3 cadherin-related family member 3
CDSN corneodesmosin
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN25 claudin 25
CLDN3 claudin 3
CLDN4 claudin 4
CLDN5 claudin 5
CLIC4 chloride intracellular channel 4
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNKSR3 CNKSR family member 3
CNN2 calponin 2
CNN3 calponin 3, acidic
CNOT12 CCR4-NOT transcription complex subunit 12
COL13A1 collagen, type XIII, alpha 1
COL17A1 collagen, type XVII, alpha 1
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRB2 crumbs family member 2
CRB3 crumbs family member 3
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
CXADR coxsackie virus and adenovirus receptor
CYTH3 cytohesin 3
DES desmin
DLG1 discs, large homolog 1 (Drosophila)
DLG5 discs, large homolog 5 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DNMBP dynamin binding protein
DSC3 desmocollin 3
DSG1 desmoglein 1
DSG2 desmoglein 2
DSG3 desmoglein 3
DSG4 desmoglein 4
DSPP dentin sialophosphoprotein
ECT2 epithelial cell transforming 2
EHD4 EH-domain containing 4
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA2 EPH receptor A2
ESAM endothelial cell adhesion molecule
EZR ezrin
F11R F11 receptor
FAT1 FAT atypical cadherin 1
FAT2 FAT atypical cadherin 2
FBF1 Fas (TNFRSF6) binding factor 1
FERMT2 fermitin family member 2
FGFR4 fibroblast growth factor receptor 4
FGFRL1 fibroblast growth factor receptor-like 1
FLCN folliculin
FLNA filamin A, alpha
FLOT1 flotillin 1
FLOT2 flotillin 2
FLRT1 fibronectin leucine rich transmembrane protein 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRMD4A FERM domain containing 4A
FRMD4B FERM domain containing 4B
FRMD5 FERM domain containing 5
FRS2 fibroblast growth factor receptor substrate 2
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GJA1 gap junction protein, alpha 1, 43kDa
GJA4 gap junction protein, alpha 4, 37kDa
GJA5 gap junction protein, alpha 5, 40kDa
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GJB6 gap junction protein, beta 6, 30kDa
GJC2 gap junction protein, gamma 2, 47kDa
GJD3 gap junction protein, delta 3, 31.9kDa
GRHL2 grainyhead-like 2 (Drosophila)
HEG1 heart development protein with EGF-like domains 1
HEPACAM hepatic and glial cell adhesion molecule
HMCN1 hemicentin 1
HPN hepsin
IGSF11 immunoglobulin superfamily, member 11
IGSF21 immunoglobin superfamily, member 21
ILDR1 immunoglobulin-like domain containing receptor 1
ILDR2 immunoglobulin-like domain containing receptor 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAG1 jagged 1
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
JCAD junctional cadherin 5 associated
JUP junction plakoglobin
KAZN kazrin, periplakin interacting protein
KIAA1210 KIAA1210
KIF20B kinesin family member 20B
KIRREL1 kirre like nephrin family adhesion molecule 1
KIRREL2 kin of IRRE like 2 (Drosophila)
KIRREL3 kin of IRRE like 3 (Drosophila)
KLHL24 kelch-like family member 24
KRIT1 KRIT1, ankyrin repeat containing
KRT18 keratin 18, type I
KRT80 keratin 80, type II
LDB3 LIM domain binding 3
LIMD1 LIM domains containing 1
LIMS1 LIM and senescent cell antigen-like domains 1
LIMS2 LIM and senescent cell antigen-like domains 2
LIN7A lin-7 homolog A (C. elegans)
LIN7B lin-7 homolog B (C. elegans)
LIN7C lin-7 homolog C (C. elegans)
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LRRC7 leucine rich repeat containing 7
LSR lipolysis stimulated lipoprotein receptor
LUZP1 leucine zipper protein 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK15 mitogen-activated protein kinase 15
MARVELD2 MARVEL domain containing 2
MICALL1 MICAL-like 1
MICALL2 MICAL-like 2
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MSN moesin
MTDH metadherin
MYADM myeloid-associated differentiation marker
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYO1E myosin IE
NDRG1 N-myc downstream regulated 1
NECTIN1 nectin cell adhesion molecule 1
NECTIN2 nectin cell adhesion molecule 2
NECTIN3 nectin cell adhesion molecule 3
NECTIN4 nectin cell adhesion molecule 4
NF2 neurofibromin 2 (merlin)
NHERF4 NHERF family PDZ scaffold protein 4
NIBAN2 niban apoptosis regulator 2
NOL6 nucleolar protein 6 (RNA-associated)
NOTCH1 notch 1
NPHP1 nephronophthisis 1 (juvenile)
NPHP4 nephronophthisis 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
OCLN occludin
OPALIN oligodendrocytic myelin paranodal and inner loop protein
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALS1 protein associated with LIN7 1, MAGUK p55 family member
PALS2 protein associated with LIN7 2, MAGUK p55 family member
PANX1 pannexin 1
PANX3 pannexin 3
PARD3 par-3 family cell polarity regulator
PARD3B par-3 family cell polarity regulator beta
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PARK7 parkinson protein 7
PATJ PATJ crumbs cell polarity complex component
PCDH1 protocadherin 1
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM3 PDZ and LIM domain 3
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PDLIM7 PDZ and LIM domain 7 (enigma)
PDZD11 PDZ domain containing 11
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PGM5 phosphoglucomutase 5
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PKN1 protein kinase N1
PKN2 protein kinase N2
PKP1 plakophilin 1
PKP2 plakophilin 2
PKP3 plakophilin 3
PKP4 plakophilin 4
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLPP3 phospholipid phosphatase 3
PNN pinin, desmosome associated protein
POF1B premature ovarian failure, 1B
POTEF POTE ankyrin domain family, member F
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRICKLE4 prickle homolog 4 (Drosophila)
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRKD2 protein kinase D2
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTK7 protein tyrosine kinase 7 (inactive)
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRM protein tyrosine phosphatase, receptor type, M
PTPRU protein tyrosine phosphatase, receptor type, U
PVR poliovirus receptor
PXDN peroxidasin
RAB10 RAB10, member RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASIP1 Ras interacting protein 1
RCAN1 regulator of calcineurin 1
RDX radixin
RHOA ras homolog family member A
RND1 Rho family GTPase 1
RPGRIP1L RPGRIP1-like
S100A11 S100 calcium binding protein A11
SAPCD2 suppressor APC domain containing 2
SCRIB scribbled planar cell polarity protein
SDCBP syndecan binding protein (syntenin)
SDCCAG8 serologically defined colon cancer antigen 8
SH3BP1 SH3-domain binding protein 1
SHROOM1 shroom family member 1
SHROOM2 shroom family member 2
SHROOM3 shroom family member 3
SHROOM4 shroom family member 4
SIRT2 sirtuin 2
SMAD7 SMAD family member 7
SNAP23 synaptosomal-associated protein, 23kDa
SORBS1 sorbin and SH3 domain containing 1
SPTBN4 spectrin, beta, non-erythrocytic 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STARD10 StAR-related lipid transfer (START) domain containing 10
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX3 syntaxin 3
STXBP6 syntaxin binding protein 6 (amisyn)
TEK TEK tyrosine kinase, endothelial
TENM2 teneurin transmembrane protein 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TLN1 talin 1
TMEM47 transmembrane protein 47
TMOD3 tropomodulin 3 (ubiquitous)
TRIM29 tripartite motif containing 29
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TWF1 twinfilin actin binding protein 1
UBA1 ubiquitin-like modifier activating enzyme 1
USP53 ubiquitin specific peptidase 53
VANGL2 VANGL planar cell polarity protein 2
VCL vinculin
VEGFA vascular endothelial growth factor A
VSIG10 V-set and immunoglobulin domain containing 10
WDR1 WD repeat domain 1
WNK3 WNK lysine deficient protein kinase 3
WTIP Wilms tumor 1 interacting protein
YAP1 Yes-associated protein 1
ZYX zyxin