cellular response to cytokine stimulus Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. (Gene Ontology, GO_0071345)
External Link http://amigo.geneontology.org/amigo/term/GO:0071345
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Genes

290 genes participating in the cellular response to cytokine stimulus biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACOD1 aconitate decarboxylase 1
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AIF1 allograft inflammatory factor 1
AIM2 absent in melanoma 2
AKAP6 A kinase (PRKA) anchor protein 6
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
AQP4 aquaporin 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
ATL1 atlastin GTPase 1
AXL AXL receptor tyrosine kinase
BAG4 BCL2-associated athanogene 4
BRCA1 breast cancer 1, early onset
CACTIN cactin, spliceosome C complex subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR7 chemokine (C-C motif) receptor 7
CD4 CD4 molecule
CD47 CD47 molecule
CD58 CD58 molecule
CDC34 cell division cycle 34
CDK9 cyclin-dependent kinase 9
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHUK conserved helix-loop-helix ubiquitous kinase
CIB1 calcium and integrin binding 1 (calmyrin)
CISH cytokine inducible SH2-containing protein
CLCF1 cardiotrophin-like cytokine factor 1
CRHBP corticotropin releasing hormone binding protein
CRIPTO3 cripto, EGF-CFC family member 3
CRLF1 cytokine receptor-like factor 1
CRLF2 cytokine receptor-like factor 2
CRNN cornulin
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTSG cathepsin G
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAPK3 death-associated protein kinase 3
DCSTAMP dendrocyte expressed seven transmembrane protein
DOCK8 dedicator of cytokinesis 8
DPYSL3 dihydropyrimidinase-like 3
DUOX1 dual oxidase 1
DUOX2 dual oxidase 2
DUSP12 dual specificity phosphatase 12
EDA ectodysplasin A
EDA2R ectodysplasin A2 receptor
EDAR ectodysplasin A receptor
EDN2 endothelin 2
EGR1 early growth response 1
EPOR erythropoietin receptor
EPRS1 glutamyl-prolyl-tRNA synthetase 1
ERBIN erbb2 interacting protein
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FCAR Fc fragment of IgA receptor
FER fer (fps/fes related) tyrosine kinase
FLT3 fms-related tyrosine kinase 3
FOXC1 forkhead box C1
FOXH1 forkhead box H1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAS6 growth arrest-specific 6
GATA3 GATA binding protein 3
GBA1 glucosylceramidase beta 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GBP4 guanylate binding protein 4
GBP5 guanylate binding protein 5
GBP6 guanylate binding protein family, member 6
GBP7 guanylate binding protein 7
GH1 growth hormone 1
GHR growth hormone receptor
GPER1 G protein-coupled estrogen receptor 1
GREM2 gremlin 2, DAN family BMP antagonist
GSDME gasdermin E
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HAS2 hyaluronan synthase 2
HAX1 HCLS1 associated protein X-1
HCK HCK proto-oncogene, Src family tyrosine kinase
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMHB1 histocompatibility (minor) HB-1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HTRA2 HtrA serine peptidase 2
HYAL2 hyaluronoglucosaminidase 2
HYAL3 hyaluronoglucosaminidase 3
IFI16 interferon, gamma-inducible protein 16
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNK interferon, kappa
IFNLR1 interferon, lambda receptor 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL11RA interleukin 11 receptor, alpha
IL12RB1 interleukin 12 receptor, beta 1
IL12RB2 interleukin 12 receptor, beta 2
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL16 interleukin 16
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1RAP interleukin 1 receptor accessory protein
IL20RA interleukin 20 receptor, alpha
IL20RB interleukin 20 receptor beta
IL21R interleukin 21 receptor
IL22RA1 interleukin 22 receptor, alpha 1
IL22RA2 interleukin 22 receptor, alpha 2
IL23R interleukin 23 receptor
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL31RA interleukin 31 receptor A
IL36A interleukin 36, alpha
IL36B interleukin 36, beta
IL36G interleukin 36, gamma
IL37 interleukin 37
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9R interleukin 9 receptor
INPP5K inositol polyphosphate-5-phosphatase K
IRAK3 interleukin-1 receptor-associated kinase 3
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
IRF8 interferon regulatory factor 8
IRGM immunity-related GTPase family, M
IRS1 insulin receptor substrate 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KHSRP KH-type splicing regulatory protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEF1 lymphoid enhancer-binding factor 1
LEPROT leptin receptor overlapping transcript
LGALS9 lectin, galactoside-binding, soluble, 9
LIFR leukemia inhibitory factor receptor alpha
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
LONP1 lon peptidase 1, mitochondrial
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAPK11 mitogen-activated protein kinase 11
MAPK13 mitogen-activated protein kinase 13
MMP12 matrix metallopeptidase 12
MNDA myeloid cell nuclear differentiation antigen
MT1X metallothionein 1X
MT2A metallothionein 2A
MYLK3 myosin light chain kinase 3
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-1 NK3 homeobox 1
NLRP7 NLR family, pyrin domain containing 7
NPNT nephronectin
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1D1 nuclear receptor subfamily 1, group D, member 1
NUMBL numb homolog (Drosophila)-like
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OCSTAMP osteoclast stimulatory transmembrane protein
OSMR oncostatin M receptor
OXSR1 oxidative stress responsive 1
P3R3URF PIK3R3 upstream open reading frame
PDE12 phosphodiesterase 12
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDE2A phosphodiesterase 2A, cGMP-stimulated
PF4 platelet factor 4
PHB1 prohibitin 1
PID1 phosphotyrosine interaction domain containing 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PNPT1 polyribonucleotide nucleotidyltransferase 1
POU4F1 POU class 4 homeobox 1
POU4F2 POU class 4 homeobox 2
PRKCA protein kinase C, alpha
PRLR prolactin receptor
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRT protein tyrosine phosphatase, receptor type, T
PYCARD PYD and CARD domain containing
PYDC5 pyrin domain containing 5
PYHIN1 pyrin and HIN domain family, member 1
RBMX RNA binding motif protein, X-linked
RC3H1 ring finger and CCCH-type domains 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHEX regulator of hemoglobinization and erythroid cell expansion
RHOA ras homolog family member A
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPOR1 RHO family interacting cell polarization regulator 1
RIPOR2 RHO family interacting cell polarization regulator 2
RO60 Ro60, Y RNA binding protein
RPL13A ribosomal protein L13a
RPS3 ribosomal protein S3
RUFY4 RUN and FYVE domain containing 4
SBNO2 strawberry notch homolog 2 (Drosophila)
SELPLG selectin P ligand
SFRP1 secreted frizzled-related protein 1
SH2B3 SH2B adaptor protein 3
SHPK sedoheptulokinase
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SOCS5 suppressor of cytokine signaling 5
SOS1 son of sevenless homolog 1 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK39 serine threonine kinase 39
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TANK TRAF family member-associated NFKB activator
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TPR translocated promoter region, nuclear basket protein
TRADD TNFRSF1A-associated via death domain
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM6-TRIM34 TRIM6-TRIM34 readthrough
TSLP thymic stromal lymphopoietin
TYK2 tyrosine kinase 2
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2K ubiquitin-conjugating enzyme E2K
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP32 ubiquitin specific peptidase 32
WNK1 WNK lysine deficient protein kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
XCL1 chemokine (C motif) ligand 1
YBX3 Y box binding protein 3
ZC3H12A zinc finger CCCH-type containing 12A
ZFAND6 zinc finger, AN1-type domain 6
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF268 zinc finger protein 268