cephaeline Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

63 genes differentially expressed following the cephaeline small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 6.23015
GADD45B growth arrest and DNA-damage-inducible, beta 5.6894
JUN jun proto-oncogene 5.67456
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 5.43215
PTBP2 polypyrimidine tract binding protein 2 5.11663
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.82755
H2BC11 H2B clustered histone 11 4.38731
EGR1 early growth response 1 4.3649
CLK4 CDC-like kinase 4 4.26733
YTHDC1 YTH domain containing 1 4.22769
THUMPD2 THUMP domain containing 2 4.13656
ARID4B AT rich interactive domain 4B (RBP1-like) 4.01995
PSPC1 paraspeckle component 1 4.00842
FOS FBJ murine osteosarcoma viral oncogene homolog 3.90858
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 3.84155
WDR33 WD repeat domain 33 3.81735
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 3.80839
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 3.76655
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 3.75701
UIMC1 ubiquitin interaction motif containing 1 3.75372
ATF3 activating transcription factor 3 3.72649
CNTRL centriolin 3.69036
HES1 hes family bHLH transcription factor 1 3.6638
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 3.62538
YJU2B YJU2 splicing factor homolog B 3.56358
JUNB jun B proto-oncogene 3.55556
H2BC12 H2B clustered histone 12 3.5505
RSRC2 arginine/serine-rich coiled-coil 2 3.54748
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 3.54394
H2AC6 H2A clustered histone 6 3.50315
ATAD2B ATPase family, AAA domain containing 2B 3.45413
DDB2 damage-specific DNA binding protein 2, 48kDa 3.43992
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 3.42483
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.37431
ING3 inhibitor of growth family, member 3 3.35272
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 3.29652
IER2 immediate early response 2 3.2948
ZNF140 zinc finger protein 140 3.26057
ZNF274 zinc finger protein 274 3.25683
CNOT4 CCR4-NOT transcription complex, subunit 4 3.20431
SNW1 SNW domain containing 1 3.18839
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 3.1852
MTF2 metal response element binding transcription factor 2 3.17891
KDM5B lysine (K)-specific demethylase 5B 3.15714
BCL3 B-cell CLL/lymphoma 3 3.10262
AKAP8L A kinase (PRKA) anchor protein 8-like 3.09949
CCNA2 cyclin A2 3.09029
TOGARAM1 TOG array regulator of axonemal microtubules 1 3.0895
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.08505
NGDN neuroguidin, EIF4E binding protein 3.07298
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 3.06156
CCL15 chemokine (C-C motif) ligand 15 3.02804
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 3.02195
PHF21A PHD finger protein 21A 3.00078

decreased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 -6.68636
NAGA N-acetylgalactosaminidase, alpha- -3.84622
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -3.71056
ENTREP3 endosomal transmembrane epsin interactor 3 -3.56393
TUBB2A tubulin, beta 2A class IIa -3.29337
PGAM1 phosphoglycerate mutase 1 (brain) -3.16191
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -3.12025
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -3.08637
TUBA1B tubulin, alpha 1b -3.06167