cftr Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)|This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1080)
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Genes

169 genes co-occuring with the biological term cftr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADCY10 adenylate cyclase 10 (soluble)
ADD1 adducin 1 (alpha)
ADK adenosine kinase
ADORA2A adenosine A2a receptor
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AHCYL1 adenosylhomocysteinase-like 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANO1 anoctamin 1, calcium activated chloride channel
ANXA2 annexin A2
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ASIC1 acid sensing (proton gated) ion channel 1
ASIC3 acid sensing (proton gated) ion channel 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BCAP31 B-cell receptor-associated protein 31
CALR calreticulin
CALU calumenin
CAPN1 calpain 1, (mu/I) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CDX2 caudal type homeobox 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHD6 chromodomain helicase DNA binding protein 6
CHRM3 cholinergic receptor, muscarinic 3
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLCA1 chloride channel accessory 1
CLCN3 chloride channel, voltage-sensitive 3
CLIC1 chloride intracellular channel 1
COMMD1 copper metabolism (Murr1) domain containing 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTCF CCCTC-binding factor (zinc finger protein)
CTRC chymotrypsin C (caldecrin)
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DERL1 derlin 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
EGFR epidermal growth factor receptor
ELF2 E74-like factor 2 (ets domain transcription factor)
EZR ezrin
FKBP8 FK506 binding protein 8, 38kDa
FLNA filamin A, alpha
FOXA1 forkhead box A1
FOXA2 forkhead box A2
GCLC glutamate-cysteine ligase, catalytic subunit
GJA5 gap junction protein, alpha 5, 40kDa
GJA8 gap junction protein, alpha 8, 50kDa
GJB1 gap junction protein, beta 1, 32kDa
GJC1 gap junction protein, gamma 1, 45kDa
GNAS GNAS complex locus
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GOPC golgi-associated PDZ and coiled-coil motif containing
GPBAR1 G protein-coupled bile acid receptor 1
GRM1 glutamate receptor, metabotropic 1
HDAC2 histone deacetylase 2
HDAC7 histone deacetylase 7
HNF1A HNF1 homeobox A
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HSPH1 heat shock 105kDa/110kDa protein 1
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL33 interleukin 33
IL4 interleukin 4
JUN jun proto-oncogene
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LMTK2 lemur tyrosine kinase 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MAST2 microtubule associated serine/threonine kinase 2
MIR101-1 microRNA 101-1
MIR138-1 microRNA 138-1
MIR144 microRNA 144
MIR145 microRNA 145
MIR193B microRNA 193b
MIR223 microRNA 223
MIR494 microRNA 494
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MSN moesin
MUC1 mucin 1, cell surface associated
MUC17 mucin 17, cell surface associated
MUC4 mucin 4, cell surface associated
MYO5B myosin VB
MYO6 myosin VI
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ORAI1 ORAI calcium release-activated calcium modulator 1
PBX1 pre-B-cell leukemia homeobox 1
PDZK1 PDZ domain containing 1
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLAU plasminogen activator, urokinase
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRSS1 protease, serine, 1 (trypsin 1)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11A RAB11A, member RAS oncogene family
RAB11B RAB11B, member RAS oncogene family
RAB27A RAB27A, member RAS oncogene family
RDX radixin
RHOQ ras homolog family member Q
RNF185 ring finger protein 185
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
S100A10 S100 calcium binding protein A10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCNN1B sodium channel, non voltage gated 1 beta subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC26A9 solute carrier family 26 (anion exchanger), member 9
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF4 serine/arginine-rich splicing factor 4
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STK39 serine threonine kinase 39
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STX16 syntaxin 16
STX1A syntaxin 1A (brain)
STX3 syntaxin 3
STX6 syntaxin 6
STX7 syntaxin 7
STX8 syntaxin 8
SYK spleen tyrosine kinase
TGFB1 transforming growth factor, beta 1
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TLR4 toll-like receptor 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRPC6 transient receptor potential cation channel, subfamily C, member 6
USP10 ubiquitin specific peptidase 10
VAMP8 vesicle-associated membrane protein 8
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VIPR1 vasoactive intestinal peptide receptor 1
VTI1B vesicle transport through interaction with t-SNAREs 1B
WNK1 WNK lysine deficient protein kinase 1
WNK4 WNK lysine deficient protein kinase 4
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta