chagas disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis. (Human Disease Ontology, DOID_12140)
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Genes

281 genes co-occuring with the disease chagas disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TCN2 transcobalamin II 2.12965
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 1.48208
CD4 CD4 molecule 1.44738
LY6E lymphocyte antigen 6 complex, locus E 1.32629
CTSL cathepsin L 1.30095
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.24211
FDPS farnesyl diphosphate synthase 1.23994
GALP galanin-like peptide 1.23863
SGOL1 shugoshin-like 1 (S. pombe) 1.22258
IFNG interferon, gamma 1.16906
GSR glutathione reductase 1.16392
PAPOLB poly(A) polymerase beta (testis specific) 1.15538
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.14178
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 1.06816
CCL5 chemokine (C-C motif) ligand 5 1.0627
DHODH dihydroorotate dehydrogenase (quinone) 1.01469
TNF tumor necrosis factor 0.99697
CALR calreticulin 0.978006
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 0.975482
SQLE squalene epoxidase 0.97086
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 0.949519
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.897872
CUX2 cut-like homeobox 2 0.897051
FYTTD1 forty-two-three domain containing 1 0.880243
LAP3 leucine aminopeptidase 3 0.879014
A2M alpha-2-macroglobulin 0.870415
TPTE transmembrane phosphatase with tensin homology 0.865502
HCFC2 host cell factor C2 0.858543
CST4 cystatin S 0.852811
MCM8 minichromosome maintenance complex component 8 0.844621
CTSB cathepsin B 0.835198
CCL3 chemokine (C-C motif) ligand 3 0.823308
TMEM165 transmembrane protein 165 0.804436
FN1 fibronectin 1 0.797462
IL10 interleukin 10 0.770844
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.770844
TLR2 toll-like receptor 2 0.751271
NID1 nidogen 1 0.745985
SNORA29 small nucleolar RNA, H/ACA box 29 0.741923
SYT7 synaptotagmin VII 0.733406
TACSTD2 tumor-associated calcium signal transducer 2 0.725311
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.714408
PRF1 perforin 1 (pore forming protein) 0.707157
CCL2 chemokine (C-C motif) ligand 2 0.69751
GJA1 gap junction protein, alpha 1, 43kDa 0.69751
CTSS cathepsin S 0.695905
BACE1 beta-site APP-cleaving enzyme 1 0.689092
ODC1 ornithine decarboxylase 1 0.670732
PRAC1 prostate cancer susceptibility candidate 1 0.665166
ADAT1 adenosine deaminase, tRNA-specific 1 0.664769
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.664769
AOX1 aldehyde oxidase 1 0.660008
CHN2 chimerin 2 0.659215
DHFR dihydrofolate reductase 0.654858
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.650113
CD69 CD69 molecule 0.649718
ZRANB2 zinc finger, RAN-binding domain containing 2 0.643797
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.62885
IL2 interleukin 2 0.628457
RAB5A RAB5A, member RAS oncogene family 0.622575
FOXP3 forkhead box P3 0.6214
NPPB natriuretic peptide B 0.620617
INPP1 inositol polyphosphate-1-phosphatase 0.61866
EDN1 endothelin 1 0.617877
CD79A CD79a molecule, immunoglobulin-associated alpha 0.616703
MASP2 mannan-binding lectin serine peptidase 2 0.616703
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.606933
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.604591
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.594843
AMD1 adenosylmethionine decarboxylase 1 0.583552
MBL2 mannose-binding lectin (protein C) 2, soluble 0.562558
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.554403
VIP vasoactive intestinal peptide 0.551298
LAMP1 lysosomal-associated membrane protein 1 0.547807
POR P450 (cytochrome) oxidoreductase 0.546256
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.540055
CAT catalase 0.531541
PNMA6A paraneoplastic Ma antigen family member 6A 0.530381
LGALS13 lectin, galactoside-binding, soluble, 13 0.51534
NTM neurotrimin 0.506507
CD19 CD19 molecule 0.505739
FBF1 Fas (TNFRSF6) binding factor 1 0.505356
KNG1 kininogen 1 0.498467
ZNF347 zinc finger protein 347 0.498085
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.497321
RAB32 RAB32, member RAS oncogene family 0.496939
HLA-B major histocompatibility complex, class I, B 0.495793
SENP6 SUMO1/sentrin specific peptidase 6 0.492359
SOCS2 suppressor of cytokine signaling 2 0.491215
PTAFR platelet-activating factor receptor 0.483604
ADRB1 adrenoceptor beta 1 0.480566
COG8 component of oligomeric golgi complex 8 0.473361
SRRM1 serine/arginine repetitive matrix 1 0.469954
DGKQ diacylglycerol kinase, theta 110kDa 0.469576
NPPC natriuretic peptide C 0.468819
KRT18 keratin 18, type I 0.46655
PGD phosphogluconate dehydrogenase 0.465038
SRM spermidine synthase 0.456355
NTSR1 neurotensin receptor 1 (high affinity) 0.452208
MPO myeloperoxidase 0.450324
DOHH deoxyhypusine hydroxylase/monooxygenase 0.449571
LGALS3 lectin, galactoside-binding, soluble, 3 0.445429
NOD1 nucleotide-binding oligomerization domain containing 1 0.443547
CD1D CD1d molecule 0.439786
ATG12 autophagy related 12 0.438658
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.432646
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.431894
SEC23A Sec23 homolog A (S. cerevisiae) 0.430393
CCNI cyclin I 0.430393
TGFB1 transforming growth factor, beta 1 0.430393
CPB1 carboxypeptidase B1 (tissue) 0.429642
CARD17 caspase recruitment domain family, member 17 0.428891
CD86 CD86 molecule 0.427015
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.42664
RARS2 arginyl-tRNA synthetase 2, mitochondrial 0.424014
NPPA natriuretic peptide A 0.42214
INTU inturned planar cell polarity protein 0.419142
CMIP c-Maf inducing protein 0.418019
CD80 CD80 molecule 0.417644
ADSL adenylosuccinate lyase 0.412031
ADGRL1 adhesion G protein-coupled receptor L1 0.407919
EEA1 early endosome antigen 1 0.398216
DGKA diacylglycerol kinase, alpha 80kDa 0.397471
IL2RA interleukin 2 receptor, alpha 0.391141
PDCL2 phosducin-like 2 0.390397
TMPRSS11D transmembrane protease, serine 11D 0.390025
CPM carboxypeptidase M 0.388538
CHRM2 cholinergic receptor, muscarinic 2 0.387794
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.387423
ACE angiotensin I converting enzyme 0.385936
NPS neuropeptide S 0.384451
CCL4 chemokine (C-C motif) ligand 4 0.383708
CD5 CD5 molecule 0.381852
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.38111
SLC25A27 solute carrier family 25, member 27 0.380368
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.379997
STRC stereocilin 0.379626
STRCP1 stereocilin pseudogene 1 0.379626
TAT tyrosine aminotransferase 0.374068
TBX21 T-box 21 0.372217
G6PD glucose-6-phosphate dehydrogenase 0.36741
MDH1 malate dehydrogenase 1, NAD (soluble) 0.363716
IL1B interleukin 1, beta 0.357814
DOCK3 dedicator of cytokinesis 3 0.357446
IL6 interleukin 6 0.355972
MAPK1 mitogen-activated protein kinase 1 0.354868
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.352291
CATSPER1 cation channel, sperm associated 1 0.351923
CHM choroideremia (Rab escort protein 1) 0.35082
IPP intracisternal A particle-promoted polypeptide 0.35082
DOCK4 dedicator of cytokinesis 4 0.345675
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.343473
ATG5 autophagy related 5 0.341272
CCR1 chemokine (C-C motif) receptor 1 0.340906
SIRT5 sirtuin 5 0.33944
SNAP91 synaptosomal-associated protein, 91kDa 0.336876
FASLG Fas ligand (TNF superfamily, member 6) 0.33651
LGALS7 lectin, galactoside-binding, soluble, 7 0.332852
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.329565
IL1A interleukin 1, alpha 0.329565
GNPDA1 glucosamine-6-phosphate deaminase 1 0.329565
CNGB1 cyclic nucleotide gated channel beta 1 0.328834
CIRBP cold inducible RNA binding protein 0.327375
NLN neurolysin (metallopeptidase M3 family) 0.324458
CD40 CD40 molecule, TNF receptor superfamily member 5 0.32373
GLB1 galactosidase, beta 1 0.322273
NMT1 N-myristoyltransferase 1 0.321181
DUS2 dihydrouridine synthase 2 0.318635
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.313915
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 0.309566
BDKRB2 bradykinin receptor B2 0.30631
VCL vinculin 0.305226
NT5E 5'-nucleotidase, ecto (CD73) 0.30342
TAC1 tachykinin, precursor 1 0.298731
PREP prolyl endopeptidase 0.295132
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.294772
PZP pregnancy-zone protein 0.290103
IL4 interleukin 4 0.289744
GAST gastrin 0.289386
RAG2 recombination activating gene 2 0.287593
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.286877
GPI glucose-6-phosphate isomerase 0.286519
SARS seryl-tRNA synthetase 0.284013
PTPRD protein tyrosine phosphatase, receptor type, D 0.280439
CXCL9 chemokine (C-X-C motif) ligand 9 0.279367
RBBP9 retinoblastoma binding protein 9 0.275089
FBXO2 F-box protein 2 0.268687
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.266913
CD44 CD44 molecule (Indian blood group) 0.264785
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.261245
CXCR3 chemokine (C-X-C motif) receptor 3 0.260538
ATF5 activating transcription factor 5 0.258064
CLEC11A C-type lectin domain family 11, member A 0.257711
CCR7 chemokine (C-C motif) receptor 7 0.257358
ADA adenosine deaminase 0.254888
GPR135 G protein-coupled receptor 135 0.254183
TSPO translocator protein (18kDa) 0.246448
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.244696
PEX14 peroxisomal biogenesis factor 14 0.244345
NGF nerve growth factor (beta polypeptide) 0.243295
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.241546
FBXO17 F-box protein 17 0.241196
MYD88 myeloid differentiation primary response 88 0.240847
GPX5 glutathione peroxidase 5 0.239101
FOSL1 FOS-like antigen 1 0.237706
GPX4 glutathione peroxidase 4 0.235964
ALB albumin 0.235964
CDCP1 CUB domain containing protein 1 0.235964
EDNRA endothelin receptor type A 0.23492
NME1-NME2 NME1-NME2 readthrough 0.230409
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.228679
C2 complement component 2 0.226607
TBXAS1 thromboxane A synthase 1 (platelet) 0.224196
GPX1 glutathione peroxidase 1 0.222136
ICAM1 intercellular adhesion molecule 1 0.222136
GSTA3 glutathione S-transferase alpha 3 0.221793
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.221108
GSTA2 glutathione S-transferase alpha 2 0.220766
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.220424
GSTA4 glutathione S-transferase alpha 4 0.21974
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.217693
CHAT choline O-acetyltransferase 0.217693
FHIT fragile histidine triad 0.216672
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.214975
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.214297
GSTA1 glutathione S-transferase alpha 1 0.214297
TIMELESS timeless circadian clock 0.213621
VRK1 vaccinia related kinase 1 0.210589
LDLR low density lipoprotein receptor 0.209248
MRC1 mannose receptor, C type 1 0.207912
SPAG7 sperm associated antigen 7 0.207245
MAN2B1 mannosidase, alpha, class 2B, member 1 0.205254
THOP1 thimet oligopeptidase 1 0.203604
DSG1 desmoglein 1 0.202618
CSTB cystatin B (stefin B) 0.200656
EOMES eomesodermin 0.198064
METTL13 methyltransferase like 13 0.197099
SIRT2 sirtuin 2 0.194548
PARG poly (ADP-ribose) glycohydrolase 0.1936
VCAM1 vascular cell adhesion molecule 1 0.191719
SOCS5 suppressor of cytokine signaling 5 0.191408
APOPT1 apoptogenic 1, mitochondrial 0.191408
ACP2 acid phosphatase 2, lysosomal 0.190476
SCN3A sodium channel, voltage gated, type III alpha subunit 0.186811
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.18591
AFM afamin 0.185016
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.18472
CPB2 carboxypeptidase B2 (plasma) 0.184128
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.184128
HLA-A major histocompatibility complex, class I, A 0.183835
IL17C interleukin 17C 0.183835
IVD isovaleryl-CoA dehydrogenase 0.183541
QPCT glutaminyl-peptide cyclotransferase 0.182375
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.182375
MIR133B microRNA 133b 0.181798
NELFCD negative elongation factor complex member C/D 0.18151
ACHE acetylcholinesterase (Yt blood group) 0.18151
NCOA3 nuclear receptor coactivator 3 0.181222
RPIA ribose 5-phosphate isomerase A 0.17952
TNNT2 troponin T type 2 (cardiac) 0.178403
PKD2L1 polycystic kidney disease 2-like 1 0.178403
ACTC1 actin, alpha, cardiac muscle 1 0.175679
CA1 carbonic anhydrase I 0.175146
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 0.174617
PHF12 PHD finger protein 12 0.173832
CD40LG CD40 ligand 0.172799
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 0.172291
BTK Bruton agammaglobulinemia tyrosine kinase 0.171535
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.170544
SGPL1 sphingosine-1-phosphate lyase 1 0.170544
MMP2 matrix metallopeptidase 2 0.170299
TLR1 toll-like receptor 1 0.170054
PLA2G1B phospholipase A2, group IB (pancreas) 0.168148
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.167915
ANK2 ankyrin 2, neuronal 0.166995
RNH1 ribonuclease/angiogenin inhibitor 1 0.164359
FST follistatin 0.163523
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.162505
CRP C-reactive protein, pentraxin-related 0.162505
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.160574
CALB2 calbindin 2 0.159124