challenge Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

134 genes co-occuring with the biological term challenge in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
ACVR1 activin A receptor, type I
ADIPOQ adiponectin, C1Q and collagen domain containing
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
BDNF brain-derived neurotrophic factor
BMP7 bone morphogenetic protein 7
BMPR1B bone morphogenetic protein receptor, type IB
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
C3AR1 complement component 3a receptor 1
CAMP cathelicidin antimicrobial peptide
CD14 CD14 molecule
CD274 CD274 molecule
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFL1 cofilin 1 (non-muscle)
CISH cytokine inducible SH2-containing protein
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFB103B defensin, beta 103B
DPP4 dipeptidyl-peptidase 4
DRD4 dopamine receptor D4
ELANE elastase, neutrophil expressed
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FASLG Fas ligand (TNF superfamily, member 6)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FHIT fragile histidine triad
FLNA filamin A, alpha
FXYD2 FXYD domain containing ion transport regulator 2
G6PD glucose-6-phosphate dehydrogenase
GATA3 GATA binding protein 3
GC group-specific component (vitamin D binding protein)
GCLC glutamate-cysteine ligase, catalytic subunit
GJB2 gap junction protein, beta 2, 26kDa
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GSTP1 glutathione S-transferase pi 1
H2AFX H2A histone family, member X
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HSPB1 heat shock 27kDa protein 1
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL17A interleukin 17A
IL1B interleukin 1, beta
IL4 interleukin 4
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL9 interleukin 9
INS insulin
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KRAS Kirsten rat sarcoma viral oncogene homolog
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LDHA lactate dehydrogenase A
LEPQTL1 Leptin, serum levels of
LEPR leptin receptor
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LIMS1 LIM and senescent cell antigen-like domains 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MB myoglobin
MBL2 mannose-binding lectin (protein C) 2, soluble
MEFV Mediterranean fever
MIR155 microRNA 155
MIR192 microRNA 192
MIR98 microRNA 98
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MRC1 mannose receptor, C type 1
MYD88 myeloid differentiation primary response 88
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NQO2 NAD(P)H dehydrogenase, quinone 2
NUCB2 nucleobindin 2
ORAI1 ORAI calcium release-activated calcium modulator 1
PDCD1 programmed cell death 1
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PNPO pyridoxamine 5'-phosphate oxidase
POMC proopiomelanocortin
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RBP4 retinol binding protein 4, plasma
RETN resistin
S100A7 S100 calcium binding protein A7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOD1 superoxide dismutase 1, soluble
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STIM1 stromal interaction molecule 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBP TATA box binding protein
TBX21 T-box 21
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
USP15 ubiquitin specific peptidase 15
UTS2 urotensin 2
VWF von Willebrand factor
WNT5A wingless-type MMTV integration site family, member 5A